| Literature DB >> 28552347 |
Niwa Ali1, Bahar Zirak2, Robert Sanchez Rodriguez2, Mariela L Pauli2, Hong-An Truong2, Kevin Lai2, Richard Ahn2, Kaitlin Corbin3, Margaret M Lowe2, Tiffany C Scharschmidt2, Keyon Taravati2, Madeleine R Tan2, Roberto R Ricardo-Gonzalez2, Audrey Nosbaum2, Marta Bertolini4, Wilson Liao2, Frank O Nestle5, Ralf Paus6, George Cotsarelis7, Abul K Abbas3, Michael D Rosenblum8.
Abstract
The maintenance of tissue homeostasis is critically dependent on the function of tissue-resident immune cells and the differentiation capacity of tissue-resident stem cells (SCs). How immune cells influence the function of SCs is largely unknown. Regulatory T cells (Tregs) in skin preferentially localize to hair follicles (HFs), which house a major subset of skin SCs (HFSCs). Here, we mechanistically dissect the role of Tregs in HF and HFSC biology. Lineage-specific cell depletion revealed that Tregs promote HF regeneration by augmenting HFSC proliferation and differentiation. Transcriptional and phenotypic profiling of Tregs and HFSCs revealed that skin-resident Tregs preferentially express high levels of the Notch ligand family member, Jagged 1 (Jag1). Expression of Jag1 on Tregs facilitated HFSC function and efficient HF regeneration. Taken together, our work demonstrates that Tregs in skin play a major role in HF biology by promoting the function of HFSCs.Entities:
Keywords: Jagged 1; Notch; alopecia areata; hair; hair follicle stem cell; hair regeneration; regulatory T cell; skin
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Year: 2017 PMID： 28552347 PMCID： PMC5504703 DOI： 10.1016/j.cell.2017.05.002
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582