Literature DB >> 28551781

The In Vivo Biology of the Mitochondrial Calcium Uniporter.

Julia C Liu1, Randi J Parks2, Jie Liu1, Justin Stares1, Ilsa I Rovira1, Elizabeth Murphy2, Toren Finkel3,4.   

Abstract

The identification of the molecular composition of the mitochondrial calcium uniporter has allowed for the genetic manipulation of its components and the creation of various in vivo genetic models. Here, we review the initial attempts to modulate the expression of components of the calcium uniporter in a range of organisms from plants to mammals. This analysis has confirmed the strict requirement for the uniporter for in vivo mitochondrial calcium uptake and for maintaining mitochondrial calcium homeostasis. We further discuss the physiological effects following genetic manipulation of the uniporter on tissue bioenergetics and the threshold for cell death. Finally, we analyze the limited information regarding the role of various uniporter components in human disease.

Entities:  

Keywords:  MCU; Mitochondrial calcium; Model organisms; Mouse models; Uniporter

Mesh：

Substances：

Year:  2017        PMID： 28551781     DOI： 10.1007/978-3-319-55330-6_3

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  13 in total

Review 1.  New Insights in Cardiac Calcium Handling and Excitation-Contraction Coupling.

Authors:  Jessica Gambardella; Bruno Trimarco; Guido Iaccarino; Gaetano Santulli
Journal:  Adv Exp Med Biol       Date:  2018       Impact factor: 2.622

2.  Targeting calcium-mediated inter-organellar crosstalk in cardiac diseases.

Authors:  Mohit M Hulsurkar; Satadru K Lahiri; Jason Karch; Meng C Wang; Xander H T Wehrens
Journal:  Expert Opin Ther Targets       Date:  2022-04-25       Impact factor: 6.797

3.  MICU1 Interacts with the D-Ring of the MCU Pore to Control Its Ca2+ Flux and Sensitivity to Ru360.

Authors:  Melanie Paillard; György Csordás; Kai-Ting Huang; Peter Várnai; Suresh K Joseph; György Hajnóczky
Journal:  Mol Cell       Date:  2018-10-25       Impact factor: 17.970

Review 4.  Pharmacological inhibition of the mitochondrial Ca2+ uniporter: Relevance for pathophysiology and human therapy.

Authors:  Katalin Márta; Prottoy Hasan; Macarena Rodríguez-Prados; Melanie Paillard; György Hajnóczky
Journal:  J Mol Cell Cardiol       Date:  2020-10-06       Impact factor: 5.000

5.  Is MCU dispensable for normal heart function?

Authors:  Julia C Liu
Journal:  J Mol Cell Cardiol       Date:  2020-05-07       Impact factor: 5.763

6.  Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure.

Authors:  Angela Lombardi; Bruno Trimarco; Guido Iaccarino; Gaetano Santulli
Journal:  Cell Commun Signal       Date:  2017-11-13       Impact factor: 5.712

Review 7.  Mitochondrial ion channels as targets for cardioprotection.

Authors:  Derek J Hausenloy; Rainer Schulz; Henrique Girao; Brenda R Kwak; Diego De Stefani; Rosario Rizzuto; Paolo Bernardi; Fabio Di Lisa
Journal:  J Cell Mol Med       Date:  2020-06-03       Impact factor: 5.310

8.  Comprehensive Genetic Characterization of Mitochondrial Ca2+ Uniporter Components Reveals Their Different Physiological Requirements In Vivo.

Authors:  Roberta Tufi; Thomas P Gleeson; Sophia von Stockum; Victoria L Hewitt; Juliette J Lee; Ana Terriente-Felix; Alvaro Sanchez-Martinez; Elena Ziviani; Alexander J Whitworth
Journal:  Cell Rep       Date:  2019-04-30       Impact factor: 9.423

Review 9.  Role of mitochondrial Ca2+ homeostasis in cardiac muscles.

Authors:  Jessica L Cao; Stephanie M Adaniya; Michael W Cypress; Yuta Suzuki; Yoichiro Kusakari; Bong Sook Jhun; Jin O-Uchi
Journal:  Arch Biochem Biophys       Date:  2019-01-23       Impact factor: 4.013

Review 10.  The Influence of MicroRNAs on Mitochondrial Calcium.

Authors:  Carolina Jaquenod De Giusti; Barbara Roman; Samarjit Das
Journal:  Front Physiol       Date:  2018-09-21       Impact factor: 4.566
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