BACKGROUND/AIM: Chronic periodontitis (CP) has already been associated with altered PSA values in men undergoing biopsy. This study addressed the impact of CP treatment on PSA screening. PATIENTS AND METHODS: Fifty-two asymptomatic men presenting for CP treatment were prospectively enrolled. Total (t)PSA, free (f)PSA and %PSA were determined (n=47) before and after therapy. Pre- and post-therapy values were correlated pairwise regarding patients and dental characteristics. RESULTS: Median age was 54 years (SD=±7.7 years) and mean tPSA was 1.3 ng/ml (±1.9 ng/ml). tPSA and fPSA correlated linearly and positively with age (p<0.002). After stratification by age, tPSA/fPSA remained significantly lower in smokers (p<0.05). No other patient or dental factor was associated with tPSA, fPSA, %PSA. CP therapy had no effect on PSA reduction and did not affect indication for biopsy. CONCLUSION: The potential influence of CP on PSA testing seems to be excludable in asymptomatic men. Copyright
BACKGROUND/AIM: Chronic periodontitis (CP) has already been associated with altered PSA values in men undergoing biopsy. This study addressed the impact of CP treatment on PSA screening. PATIENTS AND METHODS: Fifty-two asymptomatic men presenting for CP treatment were prospectively enrolled. Total (t)PSA, free (f)PSA and %PSA were determined (n=47) before and after therapy. Pre- and post-therapy values were correlated pairwise regarding patients and dental characteristics. RESULTS: Median age was 54 years (SD=±7.7 years) and mean tPSA was 1.3 ng/ml (±1.9 ng/ml). tPSA and fPSA correlated linearly and positively with age (p<0.002). After stratification by age, tPSA/fPSA remained significantly lower in smokers (p<0.05). No other patient or dental factor was associated with tPSA, fPSA, %PSA. CP therapy had no effect on PSA reduction and did not affect indication for biopsy. CONCLUSION: The potential influence of CP on PSA testing seems to be excludable in asymptomatic men. Copyright
Authors: Yuhan Huang; Dominique S Michaud; Jiayun Lu; H Ballentine Carter; Elizabeth A Platz Journal: Cancer Causes Control Date: 2019-10-21 Impact factor: 2.506
Authors: Hanna Tuominen; Mikko Taina; Mirja Puranen; Juha Onatsu; Sisko Huumonen; Ritva Vanninen Journal: In Vivo Date: 2020 Sep-Oct Impact factor: 2.155