Literature DB >> 28550651

A new biphenyl ether derivative produced by Indonesian ascidian-derived Penicillium albobiverticillium.

Deiske A Sumilat1,2, Hiroyuki Yamazaki3, Kotaro Endo1, Henki Rotinsulu1,4, Defny S Wewengkang1,4, Kazuyo Ukai1, Michio Namikoshi1.   

Abstract

A new biphenyl ether derivative, 2-hydroxy-6-(2'-hydroxy-3'-hydroxymethyl-5-methylphenoxy)-benzoic acid (1), was isolated together with the known benzophenone derivative, monodictyphenone (2), from a culture broth of Indonesian ascidian-derived Penicillium albobiverticillium TPU1432 by solvent extraction, ODS column chromatography, and preparative HPLC (ODS). The structure of 1 was elucidated based on NMR experiments. Compound 2 exhibited moderate inhibitory activities against protein tyrosine phosphatase (PTP) 1B, T cell PTP (TCPTP), and CD45 tyrosine phosphatase (CD45), whereas compound 1 modestly inhibited CD45 activity.

Entities:  

Keywords:  Ascidian-derived fungus; Biphenyl ether; Inhibitor; Penicillium albobiverticillium; Protein tyrosine phosphatase 1B

Mesh：

Substances：

Year:  2017        PMID： 28550651     DOI： 10.1007/s11418-017-1094-5

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  11 in total

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