Stefan Buettner1, Jeroen L A van Vugt2, Marcia P Gaspersz2, Robert J S Coelen3, Eva Roos3, Tim A Labeur3, Georgios A Margonis4, Cecilia G Ethun5, Shishir K Maithel5, George Poultsides6, Thuy Tran6, Kamran Idrees7, Chelsea A Isom7, Ryan C Fields8, Bradley A Krasnick8, Sharon M Weber9, Ahmed Salem9, Robert C G Martin10, Charles R Scoggins10, Perry Shen11, Harveshp D Mogal11, Carl Schmidt12, Eliza Beal12, Ioannis Hatzaras13, Rivfka Shenoy13, Jan N M IJzermans2, Thomas M van Gulik3, Timothy M Pawlik4, Bas Groot Koerkamp14. 1. Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands; Department of Surgery, Johns Hopkins Hospital, Baltimore, MD, United States. 2. Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands. 3. Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands. 4. Department of Surgery, Johns Hopkins Hospital, Baltimore, MD, United States. 5. Department of Surgery, Emory University School of Medicine, Atlanta, GA, United States. 6. Department of Surgery, Stanford University Medical Center, Stanford, CA, United States. 7. Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, United States. 8. Department of Surgery, Washington University School of Medicine, St Louis, MO, United States. 9. Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States. 10. Department of Surgery, University of Louisville, Louisville, KY, United States. 11. Department of Surgery, Wake Forest University, Winston-Salem, NC, United States. 12. Department of Surgery, Ohio State University, Columbus, OH, United States. 13. Department of Surgery, New York University, New York, NY, United States. 14. Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands. Electronic address: b.grootkoerkamp@erasmusmc.nl.
Abstract
BACKGROUND: The aim of this study was to compare patients with PHC with lymph node metastases (LN+) who underwent a resection with patients who did not undergo resection because of locally advanced disease at exploratory laparotomy. METHODS: Consecutive LN+ patients who underwent a resection for PHC in 12 centers were compared with patients who did not undergo resection because of locally advanced disease at exploratory laparotomy in 2 centers. RESULTS: In the resected cohort of 119 patients, the median overall survival (OS) was 19 months and the estimated 1-, 3- and 5-year OS was 69%, 27% and 13%, respectively. In the non-resected cohort of 113 patients, median OS was 12 months and the estimated 1-, 3- and 5-year OS was 49%, 7%, and 3%, respectively. OS was better in the resected LN+ cohort (p < 0.001). Positive resection margin (hazard ratio [HR]: 1.54; 95%CI: 0.97-2.45) and lymphovascular invasion (LVI) (HR: 1.71; 95%CI: 1.09-2.69) were independent poor prognostic factors in the resected cohort. CONCLUSION: Patients with PHC who underwent a resection for LN+ disease had better OS than patients who did not undergo resection because of locally advanced disease at exploratory laparotomy. LN+ PHC does not preclude 5-year survival after resection.
BACKGROUND: The aim of this study was to compare patients with PHC with lymph node metastases (LN+) who underwent a resection with patients who did not undergo resection because of locally advanced disease at exploratory laparotomy. METHODS: Consecutive LN+ patients who underwent a resection for PHC in 12 centers were compared with patients who did not undergo resection because of locally advanced disease at exploratory laparotomy in 2 centers. RESULTS: In the resected cohort of 119 patients, the median overall survival (OS) was 19 months and the estimated 1-, 3- and 5-year OS was 69%, 27% and 13%, respectively. In the non-resected cohort of 113 patients, median OS was 12 months and the estimated 1-, 3- and 5-year OS was 49%, 7%, and 3%, respectively. OS was better in the resected LN+ cohort (p < 0.001). Positive resection margin (hazard ratio [HR]: 1.54; 95%CI: 0.97-2.45) and lymphovascular invasion (LVI) (HR: 1.71; 95%CI: 1.09-2.69) were independent poor prognostic factors in the resected cohort. CONCLUSION:Patients with PHC who underwent a resection for LN+ disease had better OS than patients who did not undergo resection because of locally advanced disease at exploratory laparotomy. LN+ PHC does not preclude 5-year survival after resection.
Authors: Rebecca M Dodson; Matthew J Weiss; David Cosgrove; Joseph M Herman; Ihab Kamel; Robert Anders; Jean-Francois H Geschwind; Timothy M Pawlik Journal: J Am Coll Surg Date: 2013-07-24 Impact factor: 6.113
Authors: Marc Rudi Engelbrecht; Seth S Katz; Thomas M van Gulik; Johan S Laméris; Otto M van Delden Journal: AJR Am J Roentgenol Date: 2015-04 Impact factor: 3.959
Authors: Juan Valle; Harpreet Wasan; Daniel H Palmer; David Cunningham; Alan Anthoney; Anthony Maraveyas; Srinivasan Madhusudan; Tim Iveson; Sharon Hughes; Stephen P Pereira; Michael Roughton; John Bridgewater Journal: N Engl J Med Date: 2010-04-08 Impact factor: 91.245
Authors: Stefan Buettner; Cecilia G Ethun; George Poultsides; Thuy Tran; Kamran Idrees; Chelsea A Isom; Matthew Weiss; Ryan C Fields; Bradley Krasnick; Sharon M Weber; Ahmed Salem; Robert C G Martin; Charles R Scoggins; Perry Shen; Harveshp D Mogal; Carl Schmidt; Eliza Beal; Ioannis Hatzaras; Rivfka Shenoy; Bas Groot Koerkamp; Shishir K Maithel; Timothy M Pawlik Journal: J Gastrointest Surg Date: 2017-09-14 Impact factor: 3.452
Authors: Lynn E Nooijen; Jesus M Banales; Marieke T de Boer; Chiara Braconi; Trine Folseraas; Alejandro Forner; Waclaw Holowko; Frederik J H Hoogwater; Heinz-Josef Klümpen; Bas Groot Koerkamp; Angela Lamarca; Adelaida La Casta; Flora López-López; Laura Izquierdo-Sánchez; Alexander Scheiter; Kirsten Utpatel; Rutger-Jan Swijnenburg; Geert Kazemier; Joris I Erdmann Journal: Cancers (Basel) Date: 2022-05-12 Impact factor: 6.575
Authors: Lynn E Nooijen; Rutger-Jan Swijnenburg; Heinz-Josef Klümpen; Joanne Verheij; Geert Kazemier; Thomas M van Gulik; Joris I Erdmann Journal: Visc Med Date: 2021-01-07
Authors: Jeroen L A van Vugt; Stefan Buettner; Stef Levolger; Robert R J Coebergh van den Braak; Mustafa Suker; Marcia P Gaspersz; Ron W F de Bruin; Cornelis Verhoef; Casper H C van Eijck; Niek Bossche; Bas Groot Koerkamp; Jan N M IJzermans Journal: PLoS One Date: 2017-10-31 Impact factor: 3.240