Miklos Palotai1, Andrea Mike2, Michele Cavallari1, Erzsebet Strammer3, Gergely Orsi4, Brian C Healy5, Katharina Schregel6, Zsolt Illes7, Charles Rg Guttmann1. 1. Center for Neurological Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. 2. Center for Neurological Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA/Division of Clinical and Experimental Neuroimmunology, Department of Neurology, University of Pecs, Pecs, Hungary. 3. Division of Clinical and Experimental Neuroimmunology, Department of Neurology, University of Pecs, Pecs, Hungary. 4. MTA-PTE Clinical Neuroscience MR Research Group, Pecs, Hungary/Department of Neurosurgery, Clinical Centre, University of Pecs, Pecs, Hungary. 5. Partners Multiple Sclerosis Center, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA/Biostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. 6. Center for Neurological Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA/Institute of Neuroradiology, University of Gottingen, Gottingen, Germany. 7. Division of Clinical and Experimental Neuroimmunology, Department of Neurology, University of Pecs, Pecs, Hungary/MTA-PTE Clinical Neuroscience MR Research Group, Pecs, Hungary/Department of Neurology, Institute of Clinical Research, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
Abstract
BACKGROUND: Reports on the relationships between white matter lesion load (WMLL) and fatigue and anxiety in multiple sclerosis (MS) are inconsistent. OBJECTIVE: To investigate the association of total and tract-specific WMLL with fatigue and anxiety. METHODS: Total and regional T2 WMLL was assessed for 19 tracts in 48 MS patients (30 females). ICBM-DTI-81 Atlas-based parcellation was combined with WMLL segmentation of T2-weighted magnetic resonance imaging (MRI). Fatigue, anxiety, and depression were assessed using Fatigue Impact Scale, State Trait Anxiety Inventory, and Beck Depression Inventory, respectively. RESULTS: Fatigue, anxiety, and depression showed significant inter-correlation. We found no association between fatigue and total or regional WMLLs, whereas anxiety was associated with total and regional WMLLs in nine tracts. After adjusting for total WMLL, age, and depression, only the column and body of the fornix (CBF) remained significantly associated with anxiety. Post hoc analyses showed no CBF lesions on T1-weighted MRI and suggested, but could not confirm, that the septum pellucidum might play a role in the pathogenesis of anxiety. CONCLUSION: Our results suggest that anxiety in MS patients may have a neuropathological substrate in the septo-fornical area, which requires further validation using larger sample size and ultra-high-field MRI in targeted prospective studies.
BACKGROUND: Reports on the relationships between white matter lesion load (WMLL) and fatigue and anxiety in multiple sclerosis (MS) are inconsistent. OBJECTIVE: To investigate the association of total and tract-specific WMLL with fatigue and anxiety. METHODS: Total and regional T2 WMLL was assessed for 19 tracts in 48 MSpatients (30 females). ICBM-DTI-81 Atlas-based parcellation was combined with WMLL segmentation of T2-weighted magnetic resonance imaging (MRI). Fatigue, anxiety, and depression were assessed using Fatigue Impact Scale, State Trait Anxiety Inventory, and Beck Depression Inventory, respectively. RESULTS:Fatigue, anxiety, and depression showed significant inter-correlation. We found no association between fatigue and total or regional WMLLs, whereas anxiety was associated with total and regional WMLLs in nine tracts. After adjusting for total WMLL, age, and depression, only the column and body of the fornix (CBF) remained significantly associated with anxiety. Post hoc analyses showed no CBF lesions on T1-weighted MRI and suggested, but could not confirm, that the septum pellucidum might play a role in the pathogenesis of anxiety. CONCLUSION: Our results suggest that anxiety in MSpatients may have a neuropathological substrate in the septo-fornical area, which requires further validation using larger sample size and ultra-high-field MRI in targeted prospective studies.
Authors: Miklos Palotai; Aria Nazeri; Michele Cavallari; Brian C Healy; Bonnie Glanz; Stefan M Gold; Howard L Weiner; Tanuja Chitnis; Charles R G Guttmann Journal: Sci Rep Date: 2019-10-14 Impact factor: 4.379
Authors: Sabela Rodríguez-Lorenzo; Lynn van Olst; Carla Rodriguez-Mogeda; Alwin Kamermans; Susanne M A van der Pol; Ernesto Rodríguez; Gijs Kooij; Helga E de Vries Journal: Elife Date: 2022-05-10 Impact factor: 8.713