We investigated whether motion correction of gated 18F-fluoride PET/CT and PET/MRI of the aortic valve could improve PET quantitation and image quality. Methods: A diffeomorphic, mass-preserving, anatomy-guided registration algorithm was used to align the PET images from 4 cardiac gates, preserving all counts, and apply them to the PET/MRI and PET/CT data of 6 patients with aortic stenosis. Measured signal-to-noise ratios (SNRs) and target-to-background ratios (TBRs) were compared with the standard method of using only the diastolic gate. Results: High-intensity aortic valve 18F-fluoride uptake was observed in all patients. After motion correction, SNR and TBR increased compared with the median diastolic gate (SNR, 51.61 vs. 21.0; TBR, 2.85 vs. 2.22) and the median summed data (SNR, 51.61 vs. 34.10; TBR, 2.85 vs. 1.95) (P = 0.028 for all). Furthermore, noise decreased from 0.105 (median, diastolic) to 0.042 (median, motion-corrected) (P = 0.028). Conclusion: Motion correction of hybrid 18F-fluoride PET markedly improves SNR, resulting in improved image quality.
We investigated whether motion correction of gated 18F-fluoride PET/CT and PET/MRI of the aortic valve could improve PET quantitation and image quality. Methods: A diffeomorphic, mass-preserving, anatomy-guided registration algorithm was used to align the PET images from 4 cardiac gates, preserving all counts, and apply them to the PET/MRI and PET/CT data of 6 patients with aortic stenosis. Measured signal-to-noise ratios (SNRs) and target-to-background ratios (TBRs) were compared with the standard method of using only the diastolic gate. Results: High-intensity aortic valve 18F-fluoride uptake was observed in all patients. After motion correction, SNR and TBR increased compared with the median diastolic gate (SNR, 51.61 vs. 21.0; TBR, 2.85 vs. 2.22) and the median summed data (SNR, 51.61 vs. 34.10; TBR, 2.85 vs. 1.95) (P = 0.028 for all). Furthermore, noise decreased from 0.105 (median, diastolic) to 0.042 (median, motion-corrected) (P = 0.028). Conclusion: Motion correction of hybrid 18F-fluoride PET markedly improves SNR, resulting in improved image quality.
Authors: Thomas A Hope; Zahi A Fayad; Kathryn J Fowler; Dawn Holley; Andrei Iagaru; Alan B McMillan; Patrick Veit-Haiback; Robert J Witte; Greg Zaharchuk; Ciprian Catana Journal: J Nucl Med Date: 2019-05-23 Impact factor: 10.057
Authors: Philip M Robson; MariaGiovanna Trivieri; Nicolas A Karakatsanis; Maria Padilla; Ronan Abgral; Marc R Dweck; Jason C Kovacic; Zahi A Fayad Journal: Phys Med Biol Date: 2018-11-14 Impact factor: 3.609
Authors: Daniele Massera; Mhairi K Doris; Sebastien Cadet; Jacek Kwiecinski; Tania A Pawade; Frederique E C M Peeters; Damini Dey; David E Newby; Marc R Dweck; Piotr J Slomka Journal: J Nucl Cardiol Date: 2018-11-29 Impact factor: 5.952
Authors: Alexander J Fletcher; Yong Y Tew; Evangelos Tzolos; Shruti S Joshi; Jakub Kaczynski; Jennifer Nash; Samuel Debono; Maria Lembo; Jacek Kwiecinski; Rong Bing; Maaz B J Syed; Mhairi K Doris; Edwin J R van Beek; Alistair J Moss; William S Jenkins; Niki L Walker; Nikhil V Joshi; Tania A Pawade; Philip D Adamson; William N Whiteley; Joanna M Wardlaw; Piotr J Slomka; Michelle C Williams; David E Newby; Marc R Dweck Journal: JACC Cardiovasc Imaging Date: 2022-02-16
Authors: Martin Lyngby Lassen; Jacek Kwiecinski; Damini Dey; Sebastien Cadet; Guido Germano; Daniel S Berman; Philip D Adamson; Alastair J Moss; Marc R Dweck; David E Newby; Piotr J Slomka Journal: Eur J Nucl Med Mol Imaging Date: 2019-08-05 Impact factor: 9.236
Authors: Philip M Robson; Damini Dey; David E Newby; Daniel Berman; Debiao Li; Zahi A Fayad; Marc R Dweck Journal: JACC Cardiovasc Imaging Date: 2017-10