Literature DB >> 28545981

The role of dyslipidemia in diabetic retinopathy.

Sandra S Hammer1, Julia V Busik2.   

Abstract

Diabetic retinopathy (DR) affects over 93million people worldwide and is the number one cause of blindness among working age adults. These indicators coupled with the projected rise of patients diagnosed with diabetes, makes DR a serious and prevalent vision threating disease. Data from recent clinical trials demonstrate that in addition to the well accepted role of hyperglycemia, dyslipidemia is an important, but often overlooked factor in the development of DR. The central aim of this review article is to showcase the critical role of dyslipidemia in DR progression as well as highlight novel therapeutic solutions that take advantage of the vital roles lipid metabolism plays in DR progression.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  ASM; Bone marrow; Cholesterol metabolism; Diabetic retinopathy; Dyslipidemia; Fatty acids; Inflammation; Liver X receptor; miR-15a

Mesh：

Year:  2017        PMID： 28545981      PMCID： PMC5702582          DOI： 10.1016/j.visres.2017.04.010

Source DB:  PubMed          Journal:  Vision Res        ISSN： 0042-6989            Impact factor:   1.886


  121 in total

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7.  Dyslipidemia, but not hyperglycemia, induces inflammatory adhesion molecules in human retinal vascular endothelial cells.

Authors:  Weiqin Chen; Donald B Jump; Maria B Grant; Walter J Esselman; Julia V Busik
Journal:  Invest Ophthalmol Vis Sci       Date:  2003-11       Impact factor: 4.799

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9.  Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity.

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10.  Remodeling of retinal Fatty acids in an animal model of diabetes: a decrease in long-chain polyunsaturated fatty acids is associated with a decrease in fatty acid elongases Elovl2 and Elovl4.

Authors:  Maria Tikhonenko; Todd A Lydic; Yun Wang; Weiqin Chen; Madalina Opreanu; Andrew Sochacki; Kelly M McSorley; Rebecca L Renis; Timothy Kern; Donald B Jump; Gavin E Reid; Julia V Busik
Journal:  Diabetes       Date:  2009-10-29       Impact factor: 9.461
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  25 in total

1.  n-3 PUFA Supplementation Alters Retinal Very-Long-Chain-PUFA Levels and Ratios in Diabetic Animal Models.

Authors:  Aruna Gorusupudi; Fu-Yen Chang; Kelly Nelson; Gregory S Hageman; Paul S Bernstein
Journal:  Mol Nutr Food Res       Date:  2019-06-28       Impact factor: 5.914

2.  Deletion of the stress-response protein REDD1 promotes ceramide-induced retinal cell death and JNK activation.

Authors:  Weiwei Dai; William P Miller; Allyson L Toro; Adam J Black; Sadie K Dierschke; Robert P Feehan; Scot R Kimball; Michael D Dennis
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3.  miR-139-5p promotes neovascularization in diabetic retinopathy by regulating the phosphatase and tensin homolog.

Authors:  Zhongwei Zhang; Caiping Song; Tao Wang; Lei Sun; Ling Qin; Jianghua Ju
Journal:  Arch Pharm Res       Date:  2021-02-20       Impact factor: 4.946

Review 4.  Lipids, hyperreflective crystalline deposits and diabetic retinopathy: potential systemic and retinal-specific effect of lipid-lowering therapies.

Authors:  Alicia J Jenkins; Maria B Grant; Julia V Busik
Journal:  Diabetologia       Date:  2022-02-11       Impact factor: 10.460

5.  Retinal Vascular Abnormalities and Microglia Activation in Mice with Deficiency in Cytochrome P450 46A1-Mediated Cholesterol Removal.

Authors:  Aicha Saadane; Natalia Mast; George Trichonas; Dibyendu Chakraborty; Sandra Hammer; Julia V Busik; Maria B Grant; Irina A Pikuleva
Journal:  Am J Pathol       Date:  2018-11-16       Impact factor: 4.307

Review 6.  Molecular Mechanisms Mediating Diabetic Retinal Neurodegeneration: Potential Research Avenues and Therapeutic Targets.

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Journal:  J Mol Neurosci       Date:  2018-10-06       Impact factor: 3.444

7.  [Association between serum CTRP9 levels and diabetic retinopathy in patients with type 2 diabetes mellitus].

Authors:  P Zhou; L Liu; W Gao
Journal:  Nan Fang Yi Ke Da Xue Xue Bao       Date:  2021-03-25

Review 8.  Role of ceramides in the pathogenesis of diabetes mellitus and its complications.

Authors:  Nawajes Mandal; Richard Grambergs; Koushik Mondal; Sandip K Basu; Faiza Tahia; Sam Dagogo-Jack
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9.  Cholesterol regulates polymodal sensory transduction in Müller glia.

Authors:  Monika Lakk; Oleg Yarishkin; Jackson M Baumann; Anthony Iuso; David Križaj
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Review 10.  Diabetic photoreceptors: Mechanisms underlying changes in structure and function.

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