Rengyi Xu1,2, Clementina Mesaros1, Liwei Weng1, Nathaniel W Snyder3, Anil Vachani1,4, Ian A Blair1, Wei-Ting Hwang1,2. 1. Penn Superfund Research Program & Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA. 2. Department of Biostatistics & Epidemiology, Perelman School of Medicine, University of Pennsylvania, PA, USA. 3. AJ Drexel Autism Institute, Drexel University, Philadelphia, PA 19104, USA. 4. Pulmonary, Allergy & Critical Care Division, Perelman School of Medicine, University of Pennsylvania, PA, USA.
Abstract
AIM: We compared three statistical methods in selecting a panel of serum lipid biomarkers for mesothelioma and asbestos exposure. MATERIALS & METHODS: Serum samples from mesothelioma, asbestos-exposed subjects and controls (40 per group) were analyzed. Three variable selection methods were considered: top-ranked predictors from univariate model, stepwise and least absolute shrinkage and selection operator. Crossed-validated area under the receiver operating characteristic curve was used to compare the prediction performance. RESULTS: Lipids with high crossed-validated area under the curve were identified. Lipid with mass-to-charge ratio of 372.31 was selected by all three methods comparing mesothelioma versus control. Lipids with mass-to-charge ratio of 1464.80 and 329.21 were selected by two models for asbestos exposure versus control. CONCLUSION: Different methods selected a similar set of serum lipids. Combining candidate biomarkers can improve prediction.
AIM: We compared three statistical methods in selecting a panel of serum lipid biomarkers for mesothelioma and asbestos exposure. MATERIALS & METHODS: Serum samples from mesothelioma, asbestos-exposed subjects and controls (40 per group) were analyzed. Three variable selection methods were considered: top-ranked predictors from univariate model, stepwise and least absolute shrinkage and selection operator. Crossed-validated area under the receiver operating characteristic curve was used to compare the prediction performance. RESULTS:Lipids with high crossed-validated area under the curve were identified. Lipid with mass-to-charge ratio of 372.31 was selected by all three methods comparing mesothelioma versus control. Lipids with mass-to-charge ratio of 1464.80 and 329.21 were selected by two models for asbestos exposure versus control. CONCLUSION: Different methods selected a similar set of serum lipids. Combining candidate biomarkers can improve prediction.
Authors: Mehmet Bayram; Isa Dongel; Ali Akbaş; Ismail Benli; Muhammed Emin Akkoyunlu; Nur Dilek Bakan Journal: Lung Date: 2013-10-30 Impact factor: 2.584
Authors: A Lacourt; C Gramond; P Rolland; S Ducamp; S Audignon; P Astoul; S Chamming's; A Gilg Soit Ilg; M Rinaldo; C Raherison; F Galateau-Salle; E Imbernon; J C Pairon; M Goldberg; P Brochard Journal: Thorax Date: 2014-02-07 Impact factor: 9.139
Authors: Bruce W S Robinson; Jenette Creaney; Richard Lake; Anna Nowak; A William Musk; Nick de Klerk; Pernilla Winzell; Karl Erik Hellstrom; Ingegerd Hellstrom Journal: Lancet Date: 2003-11-15 Impact factor: 79.321
Authors: C Boutin; E Nussbaum; I Monnet; J Bignon; R Vanderschueren; J C Guerin; O Menard; P Mignot; G Dabouis; J Y Douillard Journal: Cancer Date: 1994-11-01 Impact factor: 6.860
Authors: Andrea Napolitano; Daniel J Antoine; Laura Pellegrini; Francine Baumann; Ian Pagano; Sandra Pastorino; Chandra M Goparaju; Kirill Prokrym; Claudia Canino; Harvey I Pass; Michele Carbone; Haining Yang Journal: Clin Cancer Res Date: 2016-01-05 Impact factor: 12.531
Authors: Michaela B Kirschner; Emily Pulford; Mir Alireza Hoda; Anita Rozsas; Kim Griggs; Yuen Yee Cheng; J James B Edelman; Steven C Kao; Rebecca Hyland; Yawen Dong; Viktoria László; Thomas Klikovits; Michael P Vallely; Michael Grusch; Balazs Hegedus; Balazs Dome; Walter Klepetko; Nico van Zandwijk; Sonja Klebe; Glen Reid Journal: Br J Cancer Date: 2015-08-11 Impact factor: 7.640
Authors: Sara M Amolegbe; Danielle J Carlin; Heather F Henry; Michelle L Heacock; Brittany A Trottier; William A Suk Journal: Exp Biol Med (Maywood) Date: 2022-03-07