Literature DB >> 28534296

Anticipating the Ethical Challenges of Psychiatric Genetic Testing.

Paul S Appelbaum1,2, Shawna Benston3.   

Abstract

PURPOSE OF REVIEW: Genetic testing for mental illness is likely to become increasingly prevalent as the science behind it is refined. This article identifies anticipated ethical challenges for patients, psychiatrists, and genetic counselors and makes recommendations for addressing them. RECENT
FINDINGS: Many of the ethical challenges of psychiatric genetic testing are likely to stem from failures to comprehend the nature and implications of test results. Recent studies have identified gaps in the knowledge base of psychiatrists and genetic counselors, which limit their abilities to provide patients with appropriate education. A small number of studies have demonstrated the value of counseling in empowering patients to deal with relevant genetic information. Psychiatrists and other health professionals must be able to assist patients and families in making informed decisions about genetic testing and interpreting test results. Filling their knowledge gaps on these issues will be a critical step towards meeting these responsibilities.

Entities:  

Keywords:  Ethics; Genetic counseling; Genetic testing; Genetics education; Mental illness; Psychiatry

Mesh:

Year:  2017        PMID: 28534296      PMCID: PMC5522712          DOI: 10.1007/s11920-017-0790-x

Source DB:  PubMed          Journal:  Curr Psychiatry Rep        ISSN: 1523-3812            Impact factor:   5.285


  43 in total

Review 1.  Genetic testing in psychiatry: a review of attitudes and beliefs.

Authors:  Ryan E Lawrence; Paul S Appelbaum
Journal:  Psychiatry       Date:  2011       Impact factor: 2.458

Review 2.  The stigmatization of mental illness in children and parents: developmental issues, family concerns, and research needs.

Authors:  Stephen P Hinshaw
Journal:  J Child Psychol Psychiatry       Date:  2005-07       Impact factor: 8.982

3.  Genetic counseling practice in next generation sequencing research: implications for the ethical oversight of the informed consent process.

Authors:  Nathalie Egalite; Iris Jaitovich Groisman; Beatrice Godard
Journal:  J Genet Couns       Date:  2014-03-25       Impact factor: 2.537

4.  The Limitations of Genetic Testing in Psychiatry.

Authors:  Steven L Dubovsky
Journal:  Psychother Psychosom       Date:  2016-04-05       Impact factor: 17.659

5.  Concerns about Genetic Testing for Schizophrenia among Young Adults at Clinical High Risk for Psychosis.

Authors:  Ryan E Lawrence; Phoebe Friesen; Gary Brucato; Ragy R Girgis; Lisa Dixon
Journal:  AJOB Empir Bioeth       Date:  2015-11-16

Review 6.  New ethical issues for genetic counseling in common mental disorders.

Authors:  Elliot S Gershon; Ney Alliey-Rodriguez
Journal:  Am J Psychiatry       Date:  2013-09       Impact factor: 18.112

7.  Pilot study on patients' and spouses' attitudes toward potential genetic testing for bipolar disorder.

Authors:  C L Trippitelli; K R Jamison; M F Folstein; J J Bartko; J R DePaulo
Journal:  Am J Psychiatry       Date:  1998-07       Impact factor: 18.112

8.  Changing interpretations, stable genes: responsibilities of patients, professionals, and policy makers in the clinical interpretation of complex genetic information.

Authors:  Brian H Shirts; Lisa S Parker
Journal:  Genet Med       Date:  2008-11       Impact factor: 8.822

9.  Technical report: Ethical and policy issues in genetic testing and screening of children.

Authors:  Lainie Friedman Ross; Laine Friedman Ross; Howard M Saal; Karen L David; Rebecca R Anderson
Journal:  Genet Med       Date:  2013-02-21       Impact factor: 8.822

10.  Biological insights from 108 schizophrenia-associated genetic loci.

Authors: 
Journal:  Nature       Date:  2014-07-22       Impact factor: 49.962

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  7 in total

1.  Testing positive for a genetic predisposition to depression magnifies retrospective memory for depressive symptoms.

Authors:  Matthew S Lebowitz; Woo-Kyoung Ahn
Journal:  J Consult Clin Psychol       Date:  2017-11

2.  Predictive Psychiatric Genetic Testing in Minors: An Exploration of the Non-Medical Benefits.

Authors:  Arianna Manzini; Danya F Vears
Journal:  J Bioeth Inq       Date:  2017-12-11       Impact factor: 1.352

3.  Psychosis, vulnerability, and the moral significance of biomedical innovation in psychiatry. Why ethicists should join efforts.

Authors:  Paolo Corsico
Journal:  Med Health Care Philos       Date:  2020-06

4.  Attitudes toward the right to autonomous decision-making in psychiatric genetic testing: Controversial and context-dependent.

Authors:  Jana Strohmaier; Stephanie H Witt; Josef Frank; Noemi Lemme; Laura Flatau; Fabian Streit; Jerome C Foo; Markus Reitt; Dan Rujescu; Thomas G Schulze; Dirk Lanzerath; Franciska Illes; Franziska Degenhardt; Marcella Rietschel
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2019-03-26       Impact factor: 3.568

5.  "It's all about delivery": researchers and health professionals' views on the moral challenges of accessing neurobiological information in the context of psychosis.

Authors:  Paolo Corsico
Journal:  BMC Med Ethics       Date:  2021-02-08       Impact factor: 2.652

Review 6.  Barriers to genetic testing in clinical psychiatry and ways to overcome them: from clinicians' attitudes to sociocultural differences between patients across the globe.

Authors:  Justo Pinzón-Espinosa; Marte van der Horst; Janneke Zinkstok; Jehannine Austin; Cora Aalfs; Albert Batalla; Patrick Sullivan; Jacob Vorstman; Jurjen J Luykx
Journal:  Transl Psychiatry       Date:  2022-10-11       Impact factor: 7.989

7.  Perceptions of causal attribution and attitudes to genetic testing among people with schizophrenia and their first-degree relatives.

Authors:  Melissa B R Cullen; Bettina Meiser; Kristine Barlow-Stewart; Melissa Green; Paul S Appelbaum; Vaughan J Carr; Murray J Cairns; M S Lebowitz; Rajneesh Kaur
Journal:  Eur J Hum Genet       Date:  2022-05-16       Impact factor: 5.351

  7 in total

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