Literature DB >> 28533245

Clonal Dissemination of OXA-232 Carbapenemase-Producing Klebsiella pneumoniae in Neonates.

Dandan Yin1, Dong Dong2,3, Ke Li4, Lei Zhang1, Jianliang Liang1, Yang Yang2, Nana Wu1, Yiyan Bao1, Chuanqing Wang5, Fupin Hu6,3.   

Abstract

Five OXA-232 carbapenemase-producing Klebsiella pneumoniae isolates, belonging to the pandemic clone sequence type 15 (ST15), were isolated from neonates and coproduced blaCTX-M-15 and blaSHV-1 genes. All isolates were resistant to ertapenem (MICs of >32 μg/ml) and meropenem (MICs of 4 to 8 μg/ml) and susceptible or intermediate to imipenem (MICs of 1 to 2 μg/ml). The blaOXA-232 gene was located on a ColE-type transformable plasmid of 6,141 bp. To the best of our knowledge, this is the first report of OXA-232 carbapenemase among clinical isolates in China.
Copyright © 2017 American Society for Microbiology.

Entities:  

Keywords:  Klebsiella pneumoniae; OXA-232; ST15; clonal dissemination; neonates

Mesh:

Substances:

Year:  2017        PMID: 28533245      PMCID: PMC5527636          DOI: 10.1128/AAC.00385-17

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN: 0066-4804            Impact factor:   5.191


  18 in total

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7.  Genetic and biochemical characterisation of OXA-232, a carbapenem-hydrolysing class D β-lactamase from Enterobacteriaceae.

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