| Literature DB >> 2853099 |
E Lötscher1, F J Zimmer, T Klopstock, K H Grzeschik, R Jaenichen, B Straubinger, H G Zachau.
Abstract
The localization of V kappa gene regions to chromosome 2, on which the kappa locus is located, and to other chromosomes is described. The V kappa genes that have been transposed to other chromosomes are called orphons. The finding of two new V kappa genes on chromosome 22 is reported. A V kappa II gene of this region and two V kappa I genes of the Chr1 and the cos 118 regions were sequenced. The two V kappa I orphon sequences and two others that had been determined previously were 97.5% identical, indicating that they may have evolved from a common ancestor by amplification. A model of the evolution of the human V kappa orphons is discussed.Entities:
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Year: 1988 PMID： 2853099 DOI： 10.1016/0378-1119(88)90432-5
Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688