Literature DB >> 28528685

IGF-I deficiency, longevity and cancer protection of patients with Laron syndrome.

Zvi Laron1, Rivka Kauli2, Lena Lapkina3, Haim Werner3.   

Abstract

Laron syndrome (LS) is a unique model of congenital IGF-I deficiency. It is characterized by dwarfism and obesity, and is caused by deletion or mutations of the growth hormone receptor (GH-R) gene. It is hypothesized that LS is an old disease originating in Indonesia and that the mutated gene spread to South Asia, the Middle East, the Mediterranean region and South America.
Copyright © 2016 Elsevier B.V. All rights reserved.

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Year:  2016        PMID： 28528685     DOI： 10.1016/j.mrrev.2016.08.002

Source DB:  PubMed          Journal:  Mutat Res Rev Mutat Res        ISSN： 1383-5742            Impact factor:   5.657


  20 in total

Review 1.  The physiology of endocrine systems with ageing.

Authors:  Annewieke W van den Beld; Jean-Marc Kaufman; M Carola Zillikens; Steven W J Lamberts; Josephine M Egan; Aart J van der Lely
Journal:  Lancet Diabetes Endocrinol       Date:  2018-07-17       Impact factor: 32.069

Review 2.  A Tale of Two Concepts: Harmonizing the Free Radical and Antagonistic Pleiotropy Theories of Aging.

Authors:  Alexey Golubev; Andrew D Hanson; Vadim N Gladyshev
Journal:  Antioxid Redox Signal       Date:  2017-10-17       Impact factor: 8.401

3.  Identification of UDP-Glucuronosyltransferase 2B15 (UGT2B15) as a Target for IGF1 and Insulin Action.

Authors:  Rive Sarfstein; Karthik Nagaraj; Shivang Parikh; Carmit Levy; Zvi Laron; Dafna Benayahu; Haim Werner
Journal:  Cells       Date:  2022-05-12       Impact factor: 7.666

Review 4.  Growth hormone - past, present and future.

Authors:  Michael B Ranke; Jan M Wit
Journal:  Nat Rev Endocrinol       Date:  2018-03-16       Impact factor: 43.330

5.  Loss of growth hormone signaling in the mouse germline or in adulthood reduces islet mass and alters islet function with notable sex differences.

Authors:  Silvana Duran-Ortiz; Kathryn L Corbin; Ishrat Jahan; Nicholas B Whitticar; Sarah E Morris; Ania N Bartholomew; Kira G Slepchenko; Hannah L West; Ibiagbani Mercy Max Harry; Edward O List; John J Kopchick; Craig S Nunemaker
Journal:  Am J Physiol Endocrinol Metab       Date:  2021-05-03       Impact factor: 5.900

6.  Toward gene therapy of Laron syndrome.

Authors:  Haim Werner
Journal:  Gene Ther       Date:  2022-03-14       Impact factor: 4.184

7.  Chasing Methuselah: adult inducible GHRKO mice.

Authors:  John J Kopchick; Darlene E Berryman; Edward O List
Journal:  Aging (Albany NY)       Date:  2022-04-13       Impact factor: 5.682

8.  Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver.

Authors:  Arne Hinrichs; Barbara Kessler; Mayuko Kurome; Andreas Blutke; Elisabeth Kemter; Maren Bernau; Armin M Scholz; Birgit Rathkolb; Simone Renner; Sebastian Bultmann; Heinrich Leonhardt; Martin Hrabĕ de Angelis; Hiroshi Nagashima; Andreas Hoeflich; Werner F Blum; Martin Bidlingmaier; Rüdiger Wanke; Maik Dahlhoff; Eckhard Wolf
Journal:  Mol Metab       Date:  2018-03-15       Impact factor: 7.422

9.  Systems Analysis of Insulin and IGF1 Receptors Networks in Breast Cancer Cells Identifies Commonalities and Divergences in Expression Patterns.

Authors:  Rive Sarfstein; Adva Yeheskel; Tali Sinai-Livne; Metsada Pasmanik-Chor; Haim Werner
Journal:  Front Endocrinol (Lausanne)       Date:  2020-07-07       Impact factor: 5.555

10.  Circulating microRNA profile in humans and mice with congenital GH deficiency.

Authors:  Tatiana D Saccon; Augusto Schneider; Cindi G Marinho; Allancer D C Nunes; Sarah Noureddine; Joseph Dhahbi; Yury O Nunez Lopez; Gage LeMunyan; Roberto Salvatori; Carla R P Oliveira; Alécia A Oliveira-Santos; Nicolas Musi; Andrzej Bartke; Manuel H Aguiar-Oliveira; Michal M Masternak
Journal:  Aging Cell       Date:  2021-06-12       Impact factor: 9.304
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