Literature DB >> 28525751

Lamina-Associated Domains: Links with Chromosome Architecture, Heterochromatin, and Gene Repression.

Bas van Steensel1, Andrew S Belmont2.   

Abstract

In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize chromosomes inside the nucleus and have been associated with gene repression. Here, we discuss the properties of LADs, the molecular mechanisms that determine their association with the nuclear lamina, their dynamic links with other nuclear compartments, and their proposed roles in gene regulation.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  LADs; chromosome architecture; gene repression; heterochromatin; lamina-associated domains; nuclear architecture

Mesh：

Substances：

Year:  2017        PMID： 28525751      PMCID： PMC5532494          DOI： 10.1016/j.cell.2017.04.022

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


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