Gugulethu Promise Shange1, Jagidesa Moodley1, Thajasvarie Naicker1. 1. a Optics and Imaging Centre, Women's Health and HIV Research Unit, Nelson R. Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban , South Africa.
Abstract
OBJECTIVE: To measure and correlate the level of vascular endothelial growth factors A, C, and D in HIV-associated pre-eclampsia. METHODS: VEGF-A, VEGF-C, and VEGF-D were measured in serum of 76 normotensive and pre-eclamptic pregnant women stratified by HIV status using Bio-Plex. RESULTS: No significant difference was shown between pre-eclamptic and normotensive and between HIV negative and positive women. A strong significant positive correlation was demonstrated between VEGF-A and VEGF-C, VEGF-A and VEGF-D, and VEGF-C and VEGF D (p < 0.0001). CONCLUSION: This study demonstrates a significant correlation between VEGF-A, VEGF-C, and VEGF-D and no difference in pre-eclamptic and normotensive pregnant women stratified by HIV status suggesting some neutralization of the immune response in HIV-associated pre-eclampsia.
OBJECTIVE: To measure and correlate the level of vascular endothelial growth factors A, C, and D in HIV-associated pre-eclampsia. METHODS:VEGF-A, VEGF-C, and VEGF-D were measured in serum of 76 normotensive and pre-eclamptic pregnant women stratified by HIV status using Bio-Plex. RESULTS: No significant difference was shown between pre-eclamptic and normotensive and between HIV negative and positive women. A strong significant positive correlation was demonstrated between VEGF-A and VEGF-C, VEGF-A and VEGF-D, and VEGF-C and VEGF D (p < 0.0001). CONCLUSION: This study demonstrates a significant correlation between VEGF-A, VEGF-C, and VEGF-D and no difference in pre-eclamptic and normotensive pregnant women stratified by HIV status suggesting some neutralization of the immune response in HIV-associated pre-eclampsia.
Authors: A J Yeates; E M McSorley; M S Mulhern; T Spence; W Crowe; K Grzesik; S W Thurston; G E Watson; G J Myers; P W Davidson; C F Shamlaye; E van Wijngaarden; J J Strain Journal: J Reprod Immunol Date: 2019-10-23 Impact factor: 4.054
Authors: Emeir M McSorley; Alison J Yeates; Maria S Mulhern; Edwin van Wijngaarden; Katherine Grzesik; Sally W Thurston; Toni Spence; William Crowe; Philip W Davidson; Grazyna Zareba; Gary J Myers; Gene E Watson; Conrad F Shamlaye; J J Strain Journal: Am J Reprod Immunol Date: 2018-09-17 Impact factor: 3.886