Literature DB >> 28523610

Motivators for Alzheimer's disease clinical trial participation.

Shoshana H Bardach1,2, Sarah D Holmes3, Gregory A Jicha4,5.   

Abstract

BACKGROUND: Alzheimer's disease (AD) research progress is impeded due to participant recruitment challenges. This study seeks to better understand, from the perspective of individuals engaged in clinical trials (CTs), research motivations.
METHODS: Participants, or their caregivers, from AD treatment and prevention CTs were surveyed about research motivators.
RESULTS: The 87 respondents had a mean age of 72.2, were predominantly Caucasian, 55.2% were male, and 56.3% had cognitive impairment. An overwhelming majority rated the potential to help themselves or a loved one and the potential to help others in the future as important motivators. Relatively few respondents were motivated by free healthcare, monetary rewards, or to make others happy.
CONCLUSIONS: Recruitment efforts should focus on the potential benefit for the individual, their loved ones, and others in the future rather than free healthcare or monetary rewards.

Entities:  

Keywords:  Clinical trials; Motivation; Recruitment

Mesh:

Year:  2017        PMID: 28523610      PMCID: PMC5896782          DOI: 10.1007/s40520-017-0771-2

Source DB:  PubMed          Journal:  Aging Clin Exp Res        ISSN: 1594-0667            Impact factor:   3.636


  11 in total

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2.  Risk disclosure and preclinical Alzheimer's disease clinical trial enrollment.

Authors:  Joshua D Grill; Jason Karlawish; David Elashoff; Barbara G Vickrey
Journal:  Alzheimers Dement       Date:  2012-11-08       Impact factor: 21.566

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Authors:  Jennifer L Watson; Laurie Ryan; Nina Silverberg; Vicky Cahan; Marie A Bernard
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Journal:  Alzheimers Dement       Date:  2015-03       Impact factor: 21.566

5.  Alzheimer's disease therapeutic trials: EU/US Task Force report on recruitment, retention, and methodology.

Authors:  B Vellas; H Hampel; M E Rougé-Bugat; M Grundman; S Andrieu; S Abu-Shakra; R Bateman; R Berman; R Black; M Carrillo; M Donohue; M Mintun; J Morris; R Petersen; R G Thomas; J Suhy; L Schneider; L Seely; P Tariot; J Touchon; M Weiner; C Sampaio; P Aisen
Journal:  J Nutr Health Aging       Date:  2012-04       Impact factor: 4.075

6.  Barriers and facilitators of African American participation in Alzheimer disease biomarker research.

Authors:  Monique M Williams; Darcell P Scharff; Katherine J Mathews; Jonathan S Hoffsuemmer; Pamela Jackson; John C Morris; Dorothy F Edwards
Journal:  Alzheimer Dis Assoc Disord       Date:  2010 Jul-Sep       Impact factor: 2.703

Review 7.  Systematic review and meta-analysis to estimate potential recruitment to dementia intervention studies.

Authors:  Claudia Cooper; Daniel Ketley; Gill Livingston
Journal:  Int J Geriatr Psychiatry       Date:  2013-10-10       Impact factor: 3.485

8.  What influences recruitment to randomised controlled trials? A review of trials funded by two UK funding agencies.

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Journal:  Trials       Date:  2006-04-07       Impact factor: 2.279

9.  Methods to improve recruitment to randomised controlled trials: Cochrane systematic review and meta-analysis.

Authors:  Shaun Treweek; Pauline Lockhart; Marie Pitkethly; Jonathan A Cook; Monica Kjeldstrøm; Marit Johansen; Taina K Taskila; Frank M Sullivan; Sue Wilson; Catherine Jackson; Ritu Jones; Elizabeth D Mitchell
Journal:  BMJ Open       Date:  2013-02-07       Impact factor: 2.692

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Authors:  Munir Boodhwani; Howard J Nathan; B Khanh Lam; Fraser D Rubens
Journal:  Trials       Date:  2006-01-05       Impact factor: 2.279

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  5 in total

1.  Non-oncology clinical trial engagement in a nationally representative sample: Identification of motivators and barriers.

Authors:  Zachary Feuer; Richard S Matulewicz; Ramsankar Basak; Donna A Culton; Kimberly Weaver; Kristalyn Gallagher; Tracy L Rose; Matthew Milowsky; Marc A Bjurlin
Journal:  Contemp Clin Trials       Date:  2022-02-22       Impact factor: 2.261

2.  Real-world Site Experiences With GeneMatch: The Role of a Recruitment-related Registry in the Context of Local Site Effort to Support Alzheimer Disease Prevention Research.

Authors:  Shoshana H Bardach; Jessica B Langbaum; Carey S Kebodeaux; Gregory A Jicha
Journal:  Alzheimer Dis Assoc Disord       Date:  2021 Apr-Jun 01       Impact factor: 2.703

3.  Recruiting Persons with Dementia and Caregivers in a Clinical Trial: Dyads Perceptions.

Authors:  Miranda V McPhillips; Darina V Petrovsky; Glenna S Brewster; Junxin Li; Nalaka S Gooneratne; Nancy A Hodgson; Justine S Sefcik
Journal:  West J Nurs Res       Date:  2021-04-17       Impact factor: 1.774

4.  Experiences of Participation in a Multimodal Preventive Trial MIND-ADMINI Among Persons with Prodromal Alzheimer's Disease: A Qualitative Study.

Authors:  Ulrika Akenine; Charlotta Thunborg; Miia Kivipelto; Mandana Fallahpour
Journal:  J Multidiscip Healthc       Date:  2022-01-29

5.  Alzheimer Disease Worries, Fears, and Stigma and Their Relationship to Genetic and Interventional Research Engagement.

Authors:  Shoshana H Bardach; Saida Kent; Gregory A Jicha
Journal:  Alzheimer Dis Assoc Disord       Date:  2021 Jan-Mar 01       Impact factor: 2.357

  5 in total

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