Catherine Feart1, Catherine Helmer2, Bénédicte Merle2, François R Herrmann3, Cédric Annweiler4, Jean-François Dartigues2, Cécile Delcourt2, Cécilia Samieri2. 1. INSERM, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France. Electronic address: Catherine.Feart-Couret@u-bordeaux.fr. 2. INSERM, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France. 3. Department of Rehabilitation and Geriatrics, Geneva University Hospitals, University of Geneva, Geneva, Switzerland. 4. Pôle de Neurosciences, Service de Gériatrie, Centre Hospitalier Universitaire d'Angers, Centre Mémoire Ressources Recherche, Centre de Recherche sur l'Autonomie et la Longévité (CeRAL), UPRES EA 4638, Université d'Angers, UNAM, Angers, France; Robarts Research Institute, The University of Western Ontario, London, Ontario, Canada.
Abstract
INTRODUCTION: Hypovitaminosis D has been associated with several chronic conditions; yet, its association with cognitive decline and the risk of dementia and Alzheimer's disease (AD) has been inconsistent. METHODS: The study population consisted of 916 participants from the Three-City Bordeaux cohort aged 65+, nondemented at baseline, with assessment of vitamin D status and who were followed for up to 12 years. RESULTS: In multivariate analysis, compared with individuals with 25(OH)D sufficiency (n = 151), participants with 25(OH)D deficiency (n = 218) exhibited a faster cognitive decline. A total of 177 dementia cases (124 AD) occurred: 25(OH)D deficiency was associated with a nearly three-fold increased risk of AD (hazard ratio = 2.85, 95% confidence interval 1.37-5.97). DISCUSSION: This large prospective study of French older adults suggests that maintaining adequate vitamin D status in older age could contribute to slow down cognitive decline and to delay or prevent the onset of dementia, especially of AD etiology.
INTRODUCTION: Hypovitaminosis D has been associated with several chronic conditions; yet, its association with cognitive decline and the risk of dementia and Alzheimer's disease (AD) has been inconsistent. METHODS: The study population consisted of 916 participants from the Three-City Bordeaux cohort aged 65+, nondemented at baseline, with assessment of vitamin D status and who were followed for up to 12 years. RESULTS: In multivariate analysis, compared with individuals with 25(OH)D sufficiency (n = 151), participants with 25(OH)D deficiency (n = 218) exhibited a faster cognitive decline. A total of 177 dementia cases (124 AD) occurred: 25(OH)D deficiency was associated with a nearly three-fold increased risk of AD (hazard ratio = 2.85, 95% confidence interval 1.37-5.97). DISCUSSION: This large prospective study of French older adults suggests that maintaining adequate vitamin D status in older age could contribute to slow down cognitive decline and to delay or prevent the onset of dementia, especially of AD etiology.
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