Literature DB >> 28520968

Measuring the Size of the Latent Human Immunodeficiency Virus Reservoir: The Present and Future of Evaluating Eradication Strategies.

Timothy J Henrich1, Steven G Deeks2, Satish K Pillai3.   

Abstract

One of the major barriers to the successful design and implementation of human immunodeficiency virus (HIV) curative strategies is the limited ability to sensitively, specifically, and precisely quantify and characterize the whole-body burden of replication-competent HIV in individuals on effective antiretroviral therapy. Here, we review the development and validation of assays that directly and indirectly measure the size and distribution of the reservoir in blood and tissues. We also discuss the role that treatment interruptions will have in validating these assays and ultimately as a "proof of cure."
© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  HIV persistence; HIV reservoirs; Human Immunodeficiency Virus (HIV); antiretroviral treatment interruption.; quantitative assays

Mesh：

Substances：

Year:  2017        PMID： 28520968      PMCID： PMC5410981          DOI： 10.1093/infdis/jiw648

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  77 in total

1.  Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells.

Authors:  Janet D Siliciano; Joleen Kajdas; Diana Finzi; Thomas C Quinn; Karen Chadwick; Joseph B Margolick; Colin Kovacs; Stephen J Gange; Robert F Siliciano
Journal:  Nat Med       Date:  2003-05-18       Impact factor: 53.440

2.  Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption.

Authors:  Meghan K Rothenberger; Brandon F Keele; Stephen W Wietgrefe; Courtney V Fletcher; Gregory J Beilman; Jeffrey G Chipman; Alexander Khoruts; Jacob D Estes; Jodi Anderson; Samuel P Callisto; Thomas E Schmidt; Ann Thorkelson; Cavan Reilly; Katherine Perkey; Thomas G Reimann; Netanya S Utay; Krystelle Nganou Makamdop; Mario Stevenson; Daniel C Douek; Ashley T Haase; Timothy W Schacker
Journal:  Proc Natl Acad Sci U S A       Date:  2015-02-23       Impact factor: 11.205

3.  Human immunodeficiency virus type 1 cellular RNA load and splicing patterns predict disease progression in a longitudinally studied cohort.

Authors:  N L Michael; T Mo; A Merzouki; M O'Shaughnessy; C Oster; D S Burke; R R Redfield; D L Birx; S A Cassol
Journal:  J Virol       Date:  1995-03       Impact factor: 5.103

4.  Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial.

Authors:  Thomas A Rasmussen; Martin Tolstrup; Christel R Brinkmann; Rikke Olesen; Christian Erikstrup; Ajantha Solomon; Anni Winckelmann; Sarah Palmer; Charles Dinarello; Maria Buzon; Mathias Lichterfeld; Sharon R Lewin; Lars Østergaard; Ole S Søgaard
Journal:  Lancet HIV       Date:  2014-09-15       Impact factor: 12.767

5.  HIV DNA Is Frequently Present within Pathologic Tissues Evaluated at Autopsy from Combined Antiretroviral Therapy-Treated Patients with Undetectable Viral Loads.

Authors:  Susanna L Lamers; Rebecca Rose; Ekaterina Maidji; Melissa Agsalda-Garcia; David J Nolan; Gary B Fogel; Marco Salemi; Debra L Garcia; Paige Bracci; William Yong; Deborah Commins; Jonathan Said; Negar Khanlou; Charles H Hinkin; Miguel Valdes Sueiras; Glenn Mathisen; Suzanne Donovan; Bruce Shiramizu; Cheryl A Stoddart; Michael S McGrath; Elyse J Singer
Journal:  J Virol       Date:  2016-09-29       Impact factor: 5.103

6.  A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice.

Authors:  Dongeun Huh; Daniel C Leslie; Benjamin D Matthews; Jacob P Fraser; Samuel Jurek; Geraldine A Hamilton; Kevin S Thorneloe; Michael Allen McAlexander; Donald E Ingber
Journal:  Sci Transl Med       Date:  2012-11-07       Impact factor: 17.956

7.  A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals.

Authors:  Francesco Andrea Procopio; Rémi Fromentin; Deanna A Kulpa; Jessica H Brehm; Anne-Gaelle Bebin; Matthew C Strain; Douglas D Richman; Una O'Doherty; Sarah Palmer; Frederick M Hecht; Rebecca Hoh; Richard J O Barnard; Michael D Miller; Daria J Hazuda; Steven G Deeks; Rafick-Pierre Sékaly; Nicolas Chomont
Journal:  EBioMedicine       Date:  2015-06-27       Impact factor: 8.143

8.  Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient.

Authors:  Steven A Yukl; Eli Boritz; Michael Busch; Christopher Bentsen; Tae-Wook Chun; Daniel Douek; Evelyn Eisele; Ashley Haase; Ya-Chi Ho; Gero Hütter; J Shawn Justement; Sheila Keating; Tzong-Hae Lee; Peilin Li; Danielle Murray; Sarah Palmer; Christopher Pilcher; Satish Pillai; Richard W Price; Meghan Rothenberger; Timothy Schacker; Janet Siliciano; Robert Siliciano; Elizabeth Sinclair; Matt Strain; Joseph Wong; Douglas Richman; Steven G Deeks
Journal:  PLoS Pathog       Date:  2013-05-09       Impact factor: 6.823

9.  Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay.

Authors:  Gregory M Laird; Evelyn E Eisele; S Alireza Rabi; Jun Lai; Stanley Chioma; Joel N Blankson; Janet D Siliciano; Robert F Siliciano
Journal:  PLoS Pathog       Date:  2013-05-30       Impact factor: 6.823

10.  HIV-1 DNA predicts disease progression and post-treatment virological control.

Authors:  James P Williams; Jacob Hurst; Wolfgang Stöhr; Nicola Robinson; Helen Brown; Martin Fisher; Sabine Kinloch; David Cooper; Mauro Schechter; Giuseppe Tambussi; Sarah Fidler; Mary Carrington; Abdel Babiker; Jonathan Weber; Kersten K Koelsch; Anthony D Kelleher; Rodney E Phillips; John Frater
Journal:  Elife       Date:  2014-09-12       Impact factor: 8.140
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  23 in total

Review 1.  Eradication of HIV from Tissue Reservoirs: Challenges for the Cure.

Authors:  Rebecca Rose; David J Nolan; Ekaterina Maidji; Cheryl A Stoddart; Elyse J Singer; Susanna L Lamers; Michael S McGrath
Journal:  AIDS Res Hum Retroviruses       Date:  2017-08-07       Impact factor: 2.205

2.  Short Communication: Ultrasensitive Immunoassay for Assessing Residual Simian-Tropic HIV in Nonhuman Primate Models of AIDS.

Authors:  Adrienne E Swanstrom; Alison Jacques; Gregory Q Del Prete; Paul Bieniasz; Theodora Hatziioannou; Robert Gorelick; Jeffrey D Lifson
Journal:  AIDS Res Hum Retroviruses       Date:  2019-02-13       Impact factor: 2.205

3.  HDAC inhibition induces HIV-1 protein and enables immune-based clearance following latency reversal.

Authors:  Guoxin Wu; Michael Swanson; Aarthi Talla; Donald Graham; Julie Strizki; Daniel Gorman; Richard Jo Barnard; Wade Blair; Ole S Søgaard; Martin Tolstrup; Lars Østergaard; Thomas A Rasmussen; Rafick-Pierre Sekaly; Nancie M Archin; David M Margolis; Daria J Hazuda; Bonnie J Howell
Journal:  JCI Insight       Date:  2017-08-17

4.  Impact of Treatment Interruption on HIV Reservoirs and Lymphocyte Subsets in Individuals Who Initiated Antiretroviral Therapy During the Early Phase of Infection.

Authors:  Erin D Huiting; Kathleen Gittens; J Shawn Justement; Victoria Shi; Jana Blazkova; Erika Benko; Colin Kovacs; Paul A Wender; Susan Moir; Michael C Sneller; Anthony S Fauci; Tae-Wook Chun
Journal:  J Infect Dis       Date:  2019-06-19       Impact factor: 5.226

Review 5.  Myeloid Cell Interaction with HIV: A Complex Relationship.

Authors:  Vasco Rodrigues; Nicolas Ruffin; Mabel San-Roman; Philippe Benaroch
Journal:  Front Immunol       Date:  2017-11-30       Impact factor: 7.561

Review 6.  Humoral and Innate Antiviral Immunity as Tools to Clear Persistent HIV Infection.

Authors:  Guido Ferrari; Justin Pollara; Georgia D Tomaras; Barton F Haynes
Journal:  J Infect Dis       Date:  2017-03-15       Impact factor: 5.226

Review 7.  When do models of NeuroAIDS faithfully imitate "the real thing"?

Authors:  Benjamin B Gelman; Janice Endsley; Dennis Kolson
Journal:  J Neurovirol       Date:  2017-12-18       Impact factor: 2.643

8.  VIP-SPOT: an Innovative Assay To Quantify the Productive HIV-1 Reservoir in the Monitoring of Cure Strategies.

Authors:  Maria C Puertas; Ángel Bayón-Gil; Maria C Garcia-Guerrero; Maria Salgado; Víctor Urrea; Sara Morón-López; Ruth Peña; Esther Jiménez-Moyano; Bonaventura Clotet; Julia G Prado; Javier Martinez-Picado
Journal:  mBio       Date:  2021-06-22       Impact factor: 7.867

Review 9.  Beyond the replication-competent HIV reservoir: transcription and translation-competent reservoirs.

Authors:  Amy E Baxter; Una O'Doherty; Daniel E Kaufmann
Journal:  Retrovirology       Date:  2018-02-02       Impact factor: 4.602

Review 10.  Ultra-Sensitive HIV-1 Latency Viral Outgrowth Assays Using Humanized Mice.

Authors:  Kimberly Schmitt; Ramesh Akkina
Journal:  Front Immunol       Date:  2018-03-05       Impact factor: 8.786
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