PURPOSE: To investigate the repeatability of vessel density measurement at human arm skin in healthy subjects with OCT-based microangiography (OMAG). METHODS: Four locations including volar wrist, volar forearm, shoulder, and volar upper arm were scanned using an optimized swept source OCT system, working at center wavelength of 1300 nm and A-line rate of 100 kHz. Three scans were acquired at each location at the same visit. Vascular images of papillary dermis, reticular dermis, and the whole dermis layer were generated with OMAG processing and automatic segmentation algorithms. The vessel density (VD) of each layer was calculated based on vascular images, and the repeatability of the VD at the same physiological location was thereafter assessed. RESULTS: Fifteen healthy volunteers were included. High repeatability of VD was found for wrist, forearm, shoulder, and upper arm (coefficient of variation (CV)=2.4, 2.7, 2.7, 2.0, and intraclass correlation coefficient (ICC)=0.906, 0.854, 0.943, 0.916 respectively). The VD measurements showed no significant difference between the four locations in any of the three layers, ie papillary layer (P=.1063), reticular layer (P=.3371), and whole dermis layer (P=.3233). CONCLUSION: Quantification of VD by using OCT/OMAG is repeatable when imaging skin tissue beds in healthy individuals.
PURPOSE: To investigate the repeatability of vessel density measurement at human arm skin in healthy subjects with OCT-based microangiography (OMAG). METHODS: Four locations including volar wrist, volar forearm, shoulder, and volar upper arm were scanned using an optimized swept source OCT system, working at center wavelength of 1300 nm and A-line rate of 100 kHz. Three scans were acquired at each location at the same visit. Vascular images of papillary dermis, reticular dermis, and the whole dermis layer were generated with OMAG processing and automatic segmentation algorithms. The vessel density (VD) of each layer was calculated based on vascular images, and the repeatability of the VD at the same physiological location was thereafter assessed. RESULTS: Fifteen healthy volunteers were included. High repeatability of VD was found for wrist, forearm, shoulder, and upper arm (coefficient of variation (CV)=2.4, 2.7, 2.7, 2.0, and intraclass correlation coefficient (ICC)=0.906, 0.854, 0.943, 0.916 respectively). The VD measurements showed no significant difference between the four locations in any of the three layers, ie papillary layer (P=.1063), reticular layer (P=.3371), and whole dermis layer (P=.3233). CONCLUSION: Quantification of VD by using OCT/OMAG is repeatable when imaging skin tissue beds in healthy individuals.
Authors: T Micantonio; A Gulia; E Altobelli; A Di Cesare; R Fidanza; A Riitano; M C Fargnoli; K Peris Journal: J Eur Acad Dermatol Venereol Date: 2011-03 Impact factor: 6.166
Authors: Peijun Gong; Shaghayegh Es'haghian; Karl-Anton Harms; Alexandra Murray; Suzanne Rea; Brendan F Kennedy; Fiona M Wood; David D Sampson; Robert A McLaughlin Journal: J Biophotonics Date: 2015-08-11 Impact factor: 3.207
Authors: Yanping Huang; Qinqin Zhang; Mariana R Thorell; Lin An; Mary K Durbin; Michal Laron; Utkarsh Sharma; Giovanni Gregori; Philip J Rosenfeld; Ruikang K Wang Journal: Ophthalmic Surg Lasers Imaging Retina Date: 2014 Sep-Oct Impact factor: 1.300
Authors: Kristen M Meiburger; Zhe Chen; Christoph Sinz; Erich Hoover; Michael Minneman; Jason Ensher; Harald Kittler; Rainer A Leitgeb; Wolfgang Drexler; Mengyang Liu Journal: J Biophotonics Date: 2019-06-18 Impact factor: 3.207
Authors: Gavrielle R Untracht; Rolando S Matos; Nikolaos Dikaios; Mariam Bapir; Abdullah K Durrani; Teemapron Butsabong; Paola Campagnolo; David D Sampson; Christian Heiss; Danuta M Sampson Journal: PLoS One Date: 2021-12-09 Impact factor: 3.240