Wei Chen1, Hua Jiang1,2, Jiong-Xian Yang1, Hao Yang2, Jing-Min Liu3, Xiu-Yuan Zhen3, Lian-Jun Feng4, Jian-Chun Yu5. 1. 1 Department of Enteral and Parenteral Nutrition, Peking Union Medical College Hospital, Medical School of Tsinghua University, Beijing, China. 2. 2 Department of Computational Mathematics and Biostatistics, Metabolomics and Multidisciplinary Laboratory for Trauma Research, Sichuan Provincial People's Hospital and Sichuan Academy of Medical Sciences, Chengdu, China. 3. 3 Department of Sports, Tsinghua University, Beijing, China. 4. 4 Stable Isotope Laboratory of Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing, China. 5. 5 Department of General Surgery, Peking Union Medical College Hospital, Medical School of Tsinghua University, Beijing, China.
Abstract
OBJECTIVE: To develop a new bioelectrical impedance analysis (BIA) model for analyzing body composition by using isotope dilution, magnetic resonance imaging (MRI), and dual-energy X-ray absorptiometry (DEXA) as the reference methods in young healthy Chinese populations. METHODS: Thirty healthy participants were enrolled. Their body composition was analyzed using BIA and 3 reference methods. We established a model that uniformed data from 3 references methods (isotope, MRI, and DEXA) into 1 formula. This model was further validated with 209 participants. RESULTS: The following BIA body composition adjustment model was developed: [Formula: see text], where X represents the impedance index; when K = 1, 2, and 3, Y represents total body water, fat mass, and bone mass, respectively. The prediction accuracy of this formula was 93.3%. By incorporating the data matrix, the protein mass was calculated using BIA: [Formula: see text]. In the verification part of this study, the lean body mass measured using DEXA and BIA was 43.02 ± 8.34 kg and 45.85 ± 8.81 kg, respectively. Analysis indicated that the model fit was extremely favorable ( R2 = .9997, P < .001). CONCLUSIONS: The accuracy of BIA measurement on body composition and protein mass is significantly improved by our work.
OBJECTIVE: To develop a new bioelectrical impedance analysis (BIA) model for analyzing body composition by using isotope dilution, magnetic resonance imaging (MRI), and dual-energy X-ray absorptiometry (DEXA) as the reference methods in young healthy Chinese populations. METHODS: Thirty healthy participants were enrolled. Their body composition was analyzed using BIA and 3 reference methods. We established a model that uniformed data from 3 references methods (isotope, MRI, and DEXA) into 1 formula. This model was further validated with 209 participants. RESULTS: The following BIA body composition adjustment model was developed: [Formula: see text], where X represents the impedance index; when K = 1, 2, and 3, Y represents total body water, fat mass, and bone mass, respectively. The prediction accuracy of this formula was 93.3%. By incorporating the data matrix, the protein mass was calculated using BIA: [Formula: see text]. In the verification part of this study, the lean body mass measured using DEXA and BIA was 43.02 ± 8.34 kg and 45.85 ± 8.81 kg, respectively. Analysis indicated that the model fit was extremely favorable ( R2 = .9997, P < .001). CONCLUSIONS: The accuracy of BIA measurement on body composition and protein mass is significantly improved by our work.