A comparison of the free radical scavenging activity of leukotrienes and prostaglandins.

The relative reactivity of leukotrienes and prostaglandins to free radicals and the superoxide ion generated by the photo oxidation of dianisidine have been assessed in vitro. Leukotrienes are effective general radical scavengers rather than superoxide scavengers, with the order of effectiveness LTD4 greater than LTC4 greater than LTB4. Prostaglandins are relatively unreactive. It is suggested that this susceptibility to free radical attack may be one reason for the formation of chemotactic agents from leukotrienes rather than prostaglandins and this may be one part of the mode of action of these compounds in chronic inflammation.