Literature DB >> 2655686

Captopril: a free radical scavenger.

M Chopra1, N Scott, J McMurray, J McLay, A Bridges, W E Smith, J J Belch.   

Abstract

The use of captopril in heart failure and hypertension is becoming increasingly accepted. Captopril has a sulphydryl group in its molecular structure. We wondered if this might confer free radical scavenging activity on the drug and have investigated this in an in vitro system. Results show that captopril is a free radical scavenger and we suggest that this action might be relevant in its use in heart failure and other vascular diseases.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2655686      PMCID： PMC1379842          DOI： 10.1111/j.1365-2125.1989.tb05384.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  11 in total

1.  Effect of captopril on kidney function in insulin-dependent diabetic patients with nephropathy.

Authors:  E Hommel; H H Parving; E Mathiesen; B Edsberg; M Damkjaer Nielsen; J Giese
Journal:  Br Med J (Clin Res Ed)       Date:  1986-08-23

2.  Antioxidant drugs and shock therapy.

Authors:  O Ortolani; M Biasiucci; A Trebbi; M Cianciulli; R Cuocolo
Journal:  Prog Clin Biol Res       Date:  1987

Review 3.  Angiotensin converting enzyme inhibitors.

Authors:  A Breckenridge
Journal:  Br Med J (Clin Res Ed)       Date:  1988-02-27

4.  A relationship between thiols and the superoxide ion.

Authors:  C J McNeil; J C Banford; D H Brown; W E Smith
Journal:  FEBS Lett       Date:  1981-10-12       Impact factor: 4.124

5.  Superoxide anion production by adriamycinol from cardiac sarcosomes and by mitochondrial NADH dehydrogenase.

Authors:  P G Gervasi; M R Agrillo; L Citti; R Danesi; M Del Tacca
Journal:  Anticancer Res       Date:  1986 Sep-Oct       Impact factor: 2.480

Review 6.  Oxygen-derived free radicals in postischemic tissue injury.

Authors:  J M McCord
Journal:  N Engl J Med       Date:  1985-01-17       Impact factor: 91.245

7.  Heparin inhibition of polymorphonuclear leukocyte activation in vitro. A possible pharmacological approach to granulocyte-mediated vascular damage.

Authors:  F Laghi Pasini; A L Pasqui; L Ceccatelli; P L Capecchi; A Orrico; T Di Perri
Journal:  Thromb Res       Date:  1984-09-01       Impact factor: 3.944

8.  Increased diene conjugates in diabetic subjects with microangiopathy.

Authors:  P E Jennings; A F Jones; C M Florkowski; J Lunec; A H Barnett
Journal:  Diabet Med       Date:  1987 Sep-Oct       Impact factor: 4.359

9.  Superoxide dismutase (erythrocuprein) and free radicals in clinical chemistry.

Authors:  J M Gutteridge
Journal:  Ann Clin Biochem       Date:  1976-05       Impact factor: 2.057

10.  A comparison of the free radical scavenging activity of leukotrienes and prostaglandins.

Authors:  M Chopra; J J Belch; W E Smith
Journal:  Free Radic Res Commun       Date:  1988
View more
  18 in total

1.  Oxygen free radicals and congestive heart failure.

Authors:  J J Belch; A B Bridges; N Scott; M Chopra
Journal:  Br Heart J       Date:  1991-05

Review 2.  Clinical pharmacology and therapeutics.

Authors:  M J Kendall; R C Horton
Journal:  Postgrad Med J       Date:  1990-03       Impact factor: 2.401

3.  Timing of captopril administration determines radiation protection or radiation sensitization in a murine model of total body irradiation.

Authors:  Thomas A Davis; Michael R Landauer; Steven R Mog; Michal Barshishat-Kupper; Stephen R Zins; Mihret F Amare; Regina M Day
Journal:  Exp Hematol       Date:  2010-01-29       Impact factor: 3.084

Review 4.  Influence of ACE inhibitors on free radicals and reperfusion injury: pharmacological curiosity or therapeutic hope?

Authors:  J McMurray; M Chopra
Journal:  Br J Clin Pharmacol       Date:  1991-04       Impact factor: 4.335

5.  Antioxidant power of angiotensin-converting enzyme inhibitors in vitro.

Authors:  I F Benzie; B Tomlinson
Journal:  Br J Clin Pharmacol       Date:  1998-02       Impact factor: 4.335

Review 6.  Mechanisms of anthracycline-mediated cardiotoxicity and preventative strategies in women with breast cancer.

Authors:  Sonu S Varghese; Cameron R Eekhoudt; Davinder S Jassal
Journal:  Mol Cell Biochem       Date:  2021-04-09       Impact factor: 3.396

7.  Preparation of bioactive peptides with high angiotensin converting enzyme inhibitory activity from winged bean [Psophocarpus tetragonolobus (L.) DC.] seed.

Authors:  Wan Abd Al-Qadr Imad Wan Mohtar; Azizah Abdul Hamid; Suraini Abd-Aziz; Sharifah Kharidah Syed Muhamad; Nazamid Saari
Journal:  J Food Sci Technol       Date:  2013-01-08       Impact factor: 2.701

8.  Effects of ACE inhibitors on oxidation of human low density lipoprotein.

Authors:  E G Godfrey; J Stewart; H J Dargie; J L Reid; M Dominiczak; C A Hamilton; J McMurray
Journal:  Br J Clin Pharmacol       Date:  1994-01       Impact factor: 4.335

9.  Possible mechanism of captopril induced endothelium-dependent relaxation in isolated rabbit aorta.

Authors:  S Mittra; M Singh
Journal:  Mol Cell Biochem       Date:  1998-06       Impact factor: 3.396

Review 10.  Pharmacokinetic optimisation of angiotensin converting enzyme (ACE) inhibitor therapy.

Authors:  M Burnier; J Biollaz
Journal:  Clin Pharmacokinet       Date:  1992-05       Impact factor: 6.447
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.