Serpil Yazgan1, Dilek Arpaci2, Haci Ugur Celik3, Irem Isik4. 1. Department of Ophthalmology, Medical Faculty, GözHastaliklari Polikiliniği, Bulent Ecevit University, C Blok, Kat 1, Esenköy, Kozlu, Zonguldak, Turkey. serpily80@gmail.com. 2. Endocrinology Division, Department of Internal Medicine, Medical Faculty, Bulent Ecevit University, Zonguldak, Turkey. 3. Department of Ophthalmology, Medical Faculty, Medeniyet University, Istanbul, Turkey. 4. Department of Ophthalmology, Medical Faculty, Bulent Ecevit University, Zonguldak, Turkey.
Abstract
PURPOSE: To evaluate macular volume, retinal nerve fiber layer, and macular and peripapillary choroidal thickness in acromegaly patients. METHOD: In this prospective, case-control study, 31 patients with acromegaly and 32 healthy subjects were recruited. Only right eyes were evaluated. Macular choroidal thickness (CT) was measured at three points, peripapillary CT was measured at eight points, and macular volume was measured at nine areas in the central 6 mm circle zone by spectraldomain optical coherence tomography (OCT). Retinal nerve fiber layer (RNFL) was measured automatically at six segments by OCT. RESULTS: The mean macular and peripapillary CT at all measuring points were significantly higher in acromegaly group (p < 0.05). RNFL thicknesses were significantly higher in acromegaly except for temporal segment (p < 0.05). The mean total, inferior and superior retinal volume of the macula were significantly higher in acromegaly group (p < 0.001), whereas there was no statistically difference was seen in retinal volume of temporal and nasal macular area between the two groups (p > 0.05). CONCLUSION: The macular and peripapillary choroidal thickness, retinal nerve fiber layer, and total retinal volume of the macula were significantly higher in acromegaly patients. Increased choroidal thickness may cause different macular pathologies such as choroidal neovascularization. RNFL results may be important in acromegaly patients with glaucoma, especially if the progress of glaucoma is monitored by OCT.
PURPOSE: To evaluate macular volume, retinal nerve fiber layer, and macular and peripapillary choroidal thickness in acromegalypatients. METHOD: In this prospective, case-control study, 31 patients with acromegaly and 32 healthy subjects were recruited. Only right eyes were evaluated. Macular choroidal thickness (CT) was measured at three points, peripapillary CT was measured at eight points, and macular volume was measured at nine areas in the central 6 mm circle zone by spectraldomain optical coherence tomography (OCT). Retinal nerve fiber layer (RNFL) was measured automatically at six segments by OCT. RESULTS: The mean macular and peripapillary CT at all measuring points were significantly higher in acromegaly group (p < 0.05). RNFL thicknesses were significantly higher in acromegaly except for temporal segment (p < 0.05). The mean total, inferior and superior retinal volume of the macula were significantly higher in acromegaly group (p < 0.001), whereas there was no statistically difference was seen in retinal volume of temporal and nasal macular area between the two groups (p > 0.05). CONCLUSION: The macular and peripapillary choroidal thickness, retinal nerve fiber layer, and total retinal volume of the macula were significantly higher in acromegalypatients. Increased choroidal thickness may cause different macular pathologies such as choroidal neovascularization. RNFL results may be important in acromegalypatients with glaucoma, especially if the progress of glaucoma is monitored by OCT.
Authors: S Kasayama; M Otsuki; M Takagi; H Saito; S Sumitani; H Kouhara; M Koga; Y Saitoh; T Ohnishi; N Arita Journal: Clin Endocrinol (Oxf) Date: 2000-05 Impact factor: 3.478