Literature DB >> 28507747

The clinical and cost implications of failed endoscopic hemostasis in gastroduodenal ulcer bleeding.

Ann Roy1, Micheline Kim1, Robert Hawes2, Shyam Varadarajulu2.   

Abstract

AIM: The aim of this article is to evaluate the clinical and cost implications of failed endoscopic hemostasis in patients with gastroduodenal ulcer bleeding.
METHODS: A retrospective claims analysis of the Medicare Provider Analysis and Review (MedPAR) file was conducted to identify all hospitalizations for gastroduodenal ulcer bleeding in the year 2012. The main outcome measures were to compare all-cause mortality, total length of hospital stay (LOS), hospital costs and payment between patients managed with one upper gastrointestinal (UGI) endoscopy versus more than one UGI endoscopy or requiring interventional radiology-guided hemostasis (IRH) or surgery after failed endoscopic attempt.
RESULTS: The MedPAR claims data evaluated 13,501 hospitalizations, of which 12,242 (90.6%) reported one UGI endoscopy, 817 (6.05%) reported >1 UGI endoscopy, 303 (2.24%) reported IRH after failed endoscopy and 139 (1.03%) reported surgeries after failed endoscopy. All cause-mortality was significantly lower for patients who underwent only one UGI endoscopy (3%) compared to patients requiring >1 endoscopy (6%), IRH (9%) or surgery (14%), p < 0.0001. The median LOS was significantly lower for patients who underwent only one UGI endoscopy (four days) compared to patients requiring >1 endoscopy (eight days), IRH (nine days) or surgery (15 days), p < 0.0001. The median hospital costs were significantly lower for patients who underwent one UGI endoscopy ($10,518) compared to patients requiring >1 endoscopy ($20,055), IRH ($34,730) or surgery ($47,589), p < 0.0001.
CONCLUSIONS: Failure to achieve hemostasis at the index endoscopy has significant clinical and cost implications. When feasible, a repeat endoscopy must be attempted followed by IRH. Surgery should preferably be reserved as a last resort for patients who fail other treatment measures.

Entities:  

Keywords:  Peptic ulcer bleeding; costs; endoscopy; interventional radiology; outcomes; surgery

Year:  2016        PMID: 28507747      PMCID: PMC5415211          DOI: 10.1177/2050640616663570

Source DB:  PubMed          Journal:  United European Gastroenterol J        ISSN: 2050-6406            Impact factor:   4.623


  13 in total

1.  A comparison of angiographic embolization with surgery after failed endoscopic hemostasis to bleeding peptic ulcers.

Authors:  Tiffany C L Wong; Ka-Tak Wong; Philip W Y Chiu; Anthony Y B Teoh; Simon C H Yu; Kim W L Au; James Y W Lau
Journal:  Gastrointest Endosc       Date:  2011-02-02       Impact factor: 9.427

2.  Acute upper gastrointestinal bleeding in the UK: patient characteristics, diagnoses and outcomes in the 2007 UK audit.

Authors:  Sarah A Hearnshaw; Richard F A Logan; Derek Lowe; Simon P L Travis; Mike F Murphy; Kelvin R Palmer
Journal:  Gut       Date:  2011-04-13       Impact factor: 23.059

3.  Surgical management of peptic ulcer bleeding by Australian and New Zealand upper gastrointestinal surgeons.

Authors:  Ewen A Griffiths; Peter G Devitt; Tim Bright; David I Watson; Sarah K Thompson
Journal:  ANZ J Surg       Date:  2013-03       Impact factor: 1.872

Review 4.  Bleeding peptic ulcer.

Authors:  L Laine; W L Peterson
Journal:  N Engl J Med       Date:  1994-09-15       Impact factor: 91.245

Review 5.  Embolization of acute nonvariceal upper gastrointestinal hemorrhage resistant to endoscopic treatment: results and predictors of recurrent bleeding.

Authors:  Romaric Loffroy; Pramod Rao; Shinichi Ota; Ming De Lin; Byung-Kook Kwak; Jean-François Geschwind
Journal:  Cardiovasc Intervent Radiol       Date:  2010-03-16       Impact factor: 2.740

6.  Endoscopic retreatment compared with surgery in patients with recurrent bleeding after initial endoscopic control of bleeding ulcers.

Authors:  J Y Lau; J J Sung; Y H Lam; A C Chan; E K Ng; D W Lee; F K Chan; R C Suen; S C Chung
Journal:  N Engl J Med       Date:  1999-03-11       Impact factor: 91.245

7.  Effect of programmed endoscopic follow-up examinations on the rebleeding rate of gastric or duodenal peptic ulcers treated by injection therapy: a prospective, randomized controlled trial.

Authors:  H Messmann; P Schaller; T Andus; G Lock; W Vogt; V Gross; H Zirngibl; K H Wiedmann; T Lingenfelser; K Bauch; H G Leser; J Schölmerich; A Holstege
Journal:  Endoscopy       Date:  1998-09       Impact factor: 10.093

Review 8.  Systematic review of the predictors of recurrent hemorrhage after endoscopic hemostatic therapy for bleeding peptic ulcers.

Authors:  B Joseph Elmunzer; Scott D Young; John M Inadomi; Philip Schoenfeld; Loren Laine
Journal:  Am J Gastroenterol       Date:  2008-08-05       Impact factor: 10.864

9.  Causes of mortality in patients with peptic ulcer bleeding: a prospective cohort study of 10,428 cases.

Authors:  Joseph J Y Sung; Kelvin K F Tsoi; Terry K W Ma; Man-Yee Yung; James Y W Lau; Philip W Y Chiu
Journal:  Am J Gastroenterol       Date:  2009-09-15       Impact factor: 10.864

10.  A systematic review of transarterial embolization versus emergency surgery in treatment of major nonvariceal upper gastrointestinal bleeding.

Authors:  Andrew D Beggs; Mark P Dilworth; Susan L Powell; Helen Atherton; Ewen A Griffiths
Journal:  Clin Exp Gastroenterol       Date:  2014-04-16
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  1 in total

1.  Impaired activity of daily living is a risk factor for high medical cost in patients of non-variceal upper gastrointestinal bleeding.

Authors:  Yusaku Takatori; Motohiko Kato; Yukie Sunata; Yuichiro Hirai; Yoko Kubosawa; Keichiro Abe; Yoshiaki Takada; Tetsu Hirata; Shigeo Banno; Michiko Wada; Satoshi Kinoshita; Hideki Mori; Kaoru Takabayashi; Miho Kikuchi; Masahiro Kikuchi; Masayuki Suzuki; Toshio Uraoka
Journal:  Surg Endosc       Date:  2018-09-12       Impact factor: 4.584

  1 in total

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