Sung Woo Joo1, Myong-Wuk Chon1, Yogesh Rathi2, Martha E Shenton3, Marek Kubicki4, Jungsun Lee5. 1. Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea. 2. Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. 3. Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; VA Boston Healthcare System, Brockton Division, Brockton, MA, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. 4. Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. 5. Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea; Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: js_lee@amc.seoul.kr.
Abstract
INTRODUCTION: Previous studies have reported abnormalities in the ventral posterior cingulate cortex (vPCC) and middle temporal gyrus (MTG) in schizophrenia patients. However, it remains unclear whether the white matter tracts connecting these structures are impaired in schizophrenia. Our study investigated the integrity of these white matter tracts (vPCC-MTG tract) and their asymmetry (left versus right side) in patients with recent onset schizophrenia. METHOD: Forty-seven patients and 24 age-and sex-matched healthy controls were enrolled in this study. We extracted left and right vPCC-MTG tract on each side from T1W and diffusion MRI (dMRI) at 3T. We then calculated the asymmetry index of diffusion measures of vPCC-MTG tracts as well as volume and thickness of vPCC and MTG using the formula: 2×(right-left)/(right+left). We compared asymmetry indices between patients and controls and evaluated their correlations with the severity of psychiatric symptoms and cognition in patients using the Positive and Negative Syndrome Scale (PANSS), video-based social cognition scale (VISC) and the Wechsler Adult Intelligence Scale (WAIS-III). RESULTS: Asymmetry of fractional anisotropy (FA) and radial diffusivity (RD) in the vPCC-MTG tract, while present in healthy controls, was not evident in schizophrenia patients. Also, we observed that patients, not healthy controls, had a significant FA decrease and RD increase in the left vPCC-MTG tract. There was no significant association between the asymmetry indices of dMRI measures and IQ, VISC, or PANSS scores in schizophrenia. CONCLUSION: Disruption of asymmetry of the vPCC-MTG tract in schizophrenia may contribute to the pathophysiology of schizophrenia.
INTRODUCTION: Previous studies have reported abnormalities in the ventral posterior cingulate cortex (vPCC) and middle temporal gyrus (MTG) in schizophreniapatients. However, it remains unclear whether the white matter tracts connecting these structures are impaired in schizophrenia. Our study investigated the integrity of these white matter tracts (vPCC-MTG tract) and their asymmetry (left versus right side) in patients with recent onset schizophrenia. METHOD: Forty-seven patients and 24 age-and sex-matched healthy controls were enrolled in this study. We extracted left and right vPCC-MTG tract on each side from T1W and diffusion MRI (dMRI) at 3T. We then calculated the asymmetry index of diffusion measures of vPCC-MTG tracts as well as volume and thickness of vPCC and MTG using the formula: 2×(right-left)/(right+left). We compared asymmetry indices between patients and controls and evaluated their correlations with the severity of psychiatric symptoms and cognition in patients using the Positive and Negative Syndrome Scale (PANSS), video-based social cognition scale (VISC) and the Wechsler Adult Intelligence Scale (WAIS-III). RESULTS: Asymmetry of fractional anisotropy (FA) and radial diffusivity (RD) in the vPCC-MTG tract, while present in healthy controls, was not evident in schizophreniapatients. Also, we observed that patients, not healthy controls, had a significant FA decrease and RD increase in the left vPCC-MTG tract. There was no significant association between the asymmetry indices of dMRI measures and IQ, VISC, or PANSS scores in schizophrenia. CONCLUSION: Disruption of asymmetry of the vPCC-MTG tract in schizophrenia may contribute to the pathophysiology of schizophrenia.
Authors: Robert G Briggs; Onur Tanglay; Nicholas B Dadario; Isabella M Young; R Dineth Fonseka; Jorge Hormovas; Vukshitha Dhanaraj; Yueh-Hsin Lin; Sihyong J Kim; Adam Bouvette; Arpan R Chakraborty; Ty M Milligan; Carol J Abraham; Christopher D Anderson; Daniel L O'Donoghue; Michael E Sughrue Journal: Oper Neurosurg (Hagerstown) Date: 2021-06-15 Impact factor: 2.703
Authors: Laurena Holleran; Sinead Kelly; Clara Alloza; Ingrid Agartz; Ole A Andreassen; Celso Arango; Nerisa Banaj; Vince Calhoun; Dara Cannon; Vaughan Carr; Aiden Corvin; David C Glahn; Ruben Gur; Elliot Hong; Cyril Hoschl; Fleur M Howells; Anthony James; Joost Janssen; Peter Kochunov; Stephen M Lawrie; Jingyu Liu; Covadonga Martinez; Colm McDonald; Derek Morris; David Mothersill; Christos Pantelis; Fabrizio Piras; Steven Potkin; Paul E Rasser; David Roalf; Laura Rowland; Theodore Satterthwaite; Ulrich Schall; Gianfranco Spalletta; Filip Spaniel; Dan J Stein; Anne Uhlmann; Aristotle Voineskos; Andrew Zalesky; Theo G M van Erp; Jessica A Turner; Ian J Deary; Paul M Thompson; Neda Jahanshad; Gary Donohoe Journal: Am J Psychiatry Date: 2020-03-26 Impact factor: 18.112