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Literature DB >> 2850473

A silencer element from the alpha-globin gene inhibits expression of beta-like genes.

G F Atweh¹, J M Liu, H E Brickner, X X Zhu.

Abstract

We have studied the cis and trans interactions of the alpha- and beta-globin genes in a transient expression system. We found that the alpha-globin gene inhibited beta-globin expression in cis but not in trans. The silencer element responsible for this inhibition was localized to a 259-base-pair fragment at the 5' end of the alpha-globin gene.

Mesh：

Substances：
Globins

Year: 1988 PMID： 2850473 PMCID： PMC365600 DOI： 10.1128/mcb.8.11.5047-5051.1988

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

17 in total

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Authors: S Wright; A Rosenthal; R Flavell; F Grosveld
Journal: Cell Date: 1984-08 Impact factor: 41.582

3. Characterization of a "silencer" in yeast: a DNA sequence with properties opposite to those of a transcriptional enhancer.

Authors: A H Brand; L Breeden; J Abraham; R Sternglanz; K Nasmyth
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5. Transcriptional interference in avian retroviruses--implications for the promoter insertion model of leukaemogenesis.

Authors: B R Cullen; P T Lomedico; G Ju
Journal: Nature Date: 1984 Jan 19-25 Impact factor: 49.962

6. Purification of genomic sequences from bacteriophage libraries by recombination and selection in vivo.

Authors: B Seed
Journal: Nucleic Acids Res Date: 1983-04-25 Impact factor: 16.971

7. Differences in human alpha-, beta- and delta-globin gene expression in monkey kidney cells.

Authors: R K Humphries; T Ley; P Turner; A D Moulton; A W Nienhuis
Journal: Cell Date: 1982-08 Impact factor: 41.582

8. cis and trans activation of globin gene transcription in transient assays.

Authors: R Treisman; M R Green; T Maniatis
Journal: Proc Natl Acad Sci U S A Date: 1983-12 Impact factor: 11.205

9. Differences in human alpha- and beta-globin gene expression in mouse erythroleukemia cells: the role of intragenic sequences.

Authors: P Charnay; R Treisman; P Mellon; M Chao; R Axel; T Maniatis
Journal: Cell Date: 1984-08 Impact factor: 41.582

10. The human beta-globin gene contains multiple regulatory regions: identification of one promoter and two downstream enhancers.

Authors: M Antoniou; E deBoer; G Habets; F Grosveld
Journal: EMBO J Date: 1988-02 Impact factor: 11.598

4 in total

1. Adult chicken alpha-globin gene expression in transfected QT6 quail cells: evidence for a negative regulatory element in the alpha D gene region.

Authors: W Lewis; J D Lee; J B Dodgson
Journal: Nucleic Acids Res Date: 1991-10-11 Impact factor: 16.971

2. CACCC and GATA-1 sequences make the constitutively expressed alpha-globin gene erythroid-responsive in mouse erythroleukemia cells.

Authors: S Ren; J Li; G F Atweh
Journal: Nucleic Acids Res Date: 1996-01-15 Impact factor: 16.971

3. Identification of a transcriptional silencer in the 5'-flanking region of the human epsilon-globin gene.

Authors: S X Cao; P D Gutman; H P Dave; A N Schechter
Journal: Proc Natl Acad Sci U S A Date: 1989-07 Impact factor: 11.205

Review 4. Negative regulation of transcription in eukaryotes.

Authors: A R Clark; K Docherty
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4 in total