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Literature DB >> 2835225

The human beta-globin gene contains multiple regulatory regions: identification of one promoter and two downstream enhancers.

M Antoniou¹, E deBoer, G Habets, F Grosveld.

Abstract

We have introduced into murine erythroleukaemia (MEL) cells several series of deletion mutants of hybrid genes between the human beta-globin gene and the murine H-2Kb gene. S1 nuclease and transcriptional run-off analysis showed that the human beta-globin gene contains at least three globin specific transcriptional control elements. One is a promoter element and is located 160 bp upstream from the transcription initiation site; it increases the efficiency of the promoter after MEL cells are induced to differentiate. The other two elements are tissue-specific transcriptional enhancers and are located downstream from the transcription initiation site, the first in the structural beta-globin gene and the second in the 3' flanking sequences.

Entities: Chemical

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Year: 1988 PMID： 2835225 PMCID： PMC454330 DOI： 10.1002/j.1460-2075.1988.tb02824.x

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

32 in total

1. Human alpha-globin gene expression following chromosomal dependent gene transfer into mouse erythroleukemia cells.

Authors: A Deisseroth; D Hendrick
Journal: Cell Date: 1978-09 Impact factor: 41.582

2. Analysis of the tissue-specific enhancer at the 3' end of the chicken adult beta-globin gene.

Authors: B M Emerson; J M Nickol; P D Jackson; G Felsenfeld
Journal: Proc Natl Acad Sci U S A Date: 1987-07 Impact factor: 11.205

3. Mutually exclusive interaction of the CCAAT-binding factor and of a displacement protein with overlapping sequences of a histone gene promoter.

Authors: A Barberis; G Superti-Furga; M Busslinger
Journal: Cell Date: 1987-07-31 Impact factor: 41.582

4. Activation of the human beta-globin promoter in K562 cells by DNA sequences 5' to the fetal gamma- or embryonic zeta-globin genes.

Authors: H J Lin; N P Anagnou; T R Rutherford; T Shimada; A W Nienhuis
Journal: J Clin Invest Date: 1987-08 Impact factor: 14.808

Review 5. Erythroleukemic differentiation.

Authors: P A Marks; R A Rifkind
Journal: Annu Rev Biochem Date: 1978 Impact factor: 23.643

6. The human beta-globin gene contains a downstream developmental specific enhancer.

Authors: G Kollias; J Hurst; E deBoer; F Grosveld
Journal: Nucleic Acids Res Date: 1987-07-24 Impact factor: 16.971

7. Cohabitation of scaffold binding regions with upstream/enhancer elements of three developmentally regulated genes of D. melanogaster.

Authors: S M Gasser; U K Laemmli
Journal: Cell Date: 1986-08-15 Impact factor: 41.582

8. Two 3' sequences direct adult erythroid-specific expression of human beta-globin genes in transgenic mice.

Authors: R R Behringer; R E Hammer; R L Brinster; R D Palmiter; T M Townes
Journal: Proc Natl Acad Sci U S A Date: 1987-10 Impact factor: 11.205

9. Regulated expression of human A gamma-, beta-, and hybrid gamma beta-globin genes in transgenic mice: manipulation of the developmental expression patterns.

Authors: G Kollias; N Wrighton; J Hurst; F Grosveld
Journal: Cell Date: 1986-07-04 Impact factor: 41.582

10. Position-independent, high-level expression of the human beta-globin gene in transgenic mice.

Authors: F Grosveld; G B van Assendelft; D R Greaves; G Kollias
Journal: Cell Date: 1987-12-24 Impact factor: 41.582

59 in total

1. Inducibility of the HS II enhancer depends on binding of an erythroid specific nuclear protein.

Authors: P A Ney; B P Sorrentino; C H Lowrey; A W Nienhuis
Journal: Nucleic Acids Res Date: 1990-10-25 Impact factor: 16.971

2. Structure and function of the enhancer 3' to the human A gamma globin gene.

Authors: M Purucker; D Bodine; H Lin; K McDonagh; A W Nienhuis
Journal: Nucleic Acids Res Date: 1990-12-25 Impact factor: 16.971

3. Multiple, compensatory regulatory elements specify spermatocyte-specific expression of the Drosophila melanogaster hsp26 gene.

Authors: R L Glaser; J T Lis
Journal: Mol Cell Biol Date: 1990-01 Impact factor: 4.272

4. Efficient, specific, developmentally appropriate cre-mediated recombination in anterior pituitary gonadotropes and thyrotropes.

Authors: María Inés Pérez-Millán; Michael G Zeidler; Thomas L Saunders; Sally A Camper; Shannon W Davis
Journal: Genesis Date: 2013-09-02 Impact factor: 2.487

5. Differential regulation of endogenous and transduced beta-globin genes during infection of erythroid cells with a herpes simplex virus type 1 recombinant.

Authors: C A Smibert; J R Smiley
Journal: J Virol Date: 1990-08 Impact factor: 5.103

6. Polymorphisms in the HBB gene relate to individual cardiorespiratory adaptation in response to endurance training.

Authors: Z He; Y Hu; L Feng; Y Lu; G Liu; Y Xi; L Wen; X Xu; K Xu
Journal: Br J Sports Med Date: 2006-09-21 Impact factor: 13.800

7. Adult chicken alpha-globin gene expression in transfected QT6 quail cells: evidence for a negative regulatory element in the alpha D gene region.

Authors: W Lewis; J D Lee; J B Dodgson
Journal: Nucleic Acids Res Date: 1991-10-11 Impact factor: 16.971

8. Derepression of mouse beta-major-globin gene transcription during erythroid differentiation.

Authors: K Macleod; M Plumb
Journal: Mol Cell Biol Date: 1991-09 Impact factor: 4.272

9. Roles of fetal G gamma-globin promoter elements and the adult beta-globin 3' enhancer in the stage-specific expression of globin genes.

Authors: C Perez-Stable; F Costantini
Journal: Mol Cell Biol Date: 1990-03 Impact factor: 4.272

10. Beta-globin enhancers target expression of a heterologous gene to erythroid tissues of transgenic mice.

Authors: J Magram; K Niederreither; F Costantini
Journal: Mol Cell Biol Date: 1989-10 Impact factor: 4.272