Literature DB >> 2850299

Okadaic acid. Protein phosphatase inhibition and muscle contractile effects.

A Takai1.   

Abstract

Okadaic acid (OA;C44H66O13) is a polyether derivative of a C38 fatty acid first isolated from marine sponges of the genus Halichondria . It is thought to be synthesized by marine diflagellates and to accumulate in the other marine organisms such as sponges and shellfishes which feed on them. Physiologically, OA has been known to have a marked contractile effect on smooth muscles and heart muscle. Recent results strongly suggest that these contractile effects are due to the inhibitory action of OA on the intracellular protein phosphatase activity.

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Year:  1988        PMID： 2850299     DOI： 10.1007/bf01738761

Source DB:  PubMed          Journal:  J Muscle Res Cell Motil        ISSN： 0142-4319            Impact factor:   2.698


  15 in total

1.  Smooth muscle myosin phosphatase inhibition and force enhancement by black sponge toxin.

Authors:  A Takai; C Bialojan; M Troschka; J C Rüegg
Journal:  FEBS Lett       Date:  1987-06-08       Impact factor: 4.124

2.  Beta-adrenergic increase in the calcium conductance of cardiac myocytes studied with the patch clamp.

Authors:  G Brum; W Osterrieder; W Trautwein
Journal:  Pflugers Arch       Date:  1984-06       Impact factor: 3.657

3.  Contractile effects of okadaic acid, a novel ionophore-like substance from black sponge, on isolated smooth muscles under the condition of Ca deficiency.

Authors:  S Shibata; Y Ishida; H Kitano; Y Ohizumi; J Habon; Y Tsukitani; H Kikuchi
Journal:  J Pharmacol Exp Ther       Date:  1982-10       Impact factor: 4.030

Review 4.  Regulation of smooth muscle actomyosin.

Authors:  D J Hartshorne; U Mrwa
Journal:  Blood Vessels       Date:  1982

5.  Effects of a protein phosphatase inhibitor, okadaic acid, on membrane currents of isolated guinea-pig cardiac myocytes.

Authors:  J Hescheler; G Mieskes; J C Rüegg; A Takai; W Trautwein
Journal:  Pflugers Arch       Date:  1988-08       Impact factor: 3.657

6.  Electromechanical effects of okadaic acid isolated from black sponge in guinea-pig ventricular muscles.

Authors:  I Kodama; N Kondo; S Shibata
Journal:  J Physiol       Date:  1986-09       Impact factor: 5.182

7.  Unique vasocontraction of okadaic acid isolated from black sponge, independent of extracellular Ca2+.

Authors:  S Shibata
Journal:  Blood Vessels       Date:  1987

8.  The influence of P-light chain phosphorylation by myosin light chain kinase on the calcium sensitivity of chemically skinned heart fibres.

Authors:  I Morano; F Hofmann; M Zimmer; J C Rüegg
Journal:  FEBS Lett       Date:  1985-09-23       Impact factor: 4.124

9.  The protein phosphatases involved in cellular regulation. 1. Classification and substrate specificities.

Authors:  T S Ingebritsen; P Cohen
Journal:  Eur J Biochem       Date:  1983-05-02

10.  Hyperphosphorylation of N-60, a protein structurally and immunologically related to nucleolin after tumour-promoter treatment.

Authors:  O G Issinger; T Martin; W W Richter; M Olson; H Fujiki
Journal:  EMBO J       Date:  1988-06       Impact factor: 11.598
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  10 in total

1.  Estimation of the rate constants associated with the inhibitory effect of okadaic acid on type 2A protein phosphatase by time-course analysis.

Authors:  A Takai; Y Ohno; T Yasumoto; G Mieskes
Journal:  Biochem J       Date:  1992-10-01       Impact factor: 3.857

2.  Inhibitory effect of okadaic acid derivatives on protein phosphatases. A study on structure-affinity relationship.

Authors:  A Takai; M Murata; K Torigoe; M Isobe; G Mieskes; T Yasumoto
Journal:  Biochem J       Date:  1992-06-01       Impact factor: 3.857

3.  Protein phosphatase composition in the smooth muscle of guinea-pig ileum studied with okadaic acid and inhibitor 2.

Authors:  A Takai; M Troschka; G Mieskes; A V Somlyo
Journal:  Biochem J       Date:  1989-09-01       Impact factor: 3.857

4.  Force-inhibiting effect of okadaic acid on skinned rat uterus permeabilized with alpha-toxin.

Authors:  M Watanabe; M Nakano
Journal:  Pflugers Arch       Date:  1995-09       Impact factor: 3.657

5.  PKC and Rho in vascular smooth muscle: activation by BOXes and SAH CSF.

Authors:  Gail J Pyne-Geithman; Sunil G Nair; Danielle N Caudell; Joseph F Clark
Journal:  Front Biosci       Date:  2008-01-01

6.  Translocation of PKC by yessotoxin in an in vitro model of Alzheimer's disease with improvement of tau and β-amyloid pathology.

Authors:  Eva Alonso; Carmen Vale; Mercedes R Vieytes; Luis M Botana
Journal:  ACS Chem Neurosci       Date:  2013-04-08       Impact factor: 4.418

Review 7.  The role of myosin I and II in cell motility.

Authors:  A K Wilson; R S Pollenz; R L Chisholm; P de Lanerolle
Journal:  Cancer Metastasis Rev       Date:  1992-03       Impact factor: 9.264

8.  NMDA receptor-mediated extracellular adenosine accumulation is blocked by phosphatase 1/2A inhibitors.

Authors:  Yin Lu; Paul A Rosenberg
Journal:  Brain Res       Date:  2007-05-04       Impact factor: 3.252

Review 9.  Protein phosphatases 1 and 2A and their naturally occurring inhibitors: current topics in smooth muscle physiology and chemical biology.

Authors:  Akira Takai; Masumi Eto; Katsuya Hirano; Kosuke Takeya; Toshiyuki Wakimoto; Masaru Watanabe
Journal:  J Physiol Sci       Date:  2017-07-05       Impact factor: 2.781

10.  Inhibitory effects of rubratoxin A, a potent inhibitor of protein phosphatase 2, on the Ca2+-dependent contraction of skinned carotid artery from guinea pig.

Authors:  Yasuyuki Naraki; Masaru Watanabe; Kosuke Takeya
Journal:  J Smooth Muscle Res       Date:  2019
  10 in total

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