Literature DB >> 3036577

Smooth muscle myosin phosphatase inhibition and force enhancement by black sponge toxin.

A Takai, C Bialojan, M Troschka, J C Rüegg.   

Abstract

Smooth muscle contraction depends on the state of myosin phosphorylation and hence on the balance of myosin light chain kinase and phosphatase activity. Effects of okadaic acid isolated from black sponge on both enzyme activities and contractility were studied in chemically skinned fibers from guinea pig taenia coli. The toxin strongly inhibits myosin phosphatase and enhances tension development.

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Year:  1987        PMID： 3036577     DOI： 10.1016/0014-5793(87)81247-4

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  62 in total

1.  Localization of the PP2A B56gamma regulatory subunit at the Golgi complex: possible role in vesicle transport and migration.

Authors:  Akihiko Ito; Yu-ichiro Koma; Miwa Sohda; Kenji Watabe; Teruaki Nagano; Yoshio Misumi; Hiroshi Nojima; Yukihiko Kitamura
Journal:  Am J Pathol       Date:  2003-02       Impact factor: 4.307

Review 2.  Protein phosphatases and their regulation in the control of mitosis.

Authors:  Satoru Mochida; Tim Hunt
Journal:  EMBO Rep       Date:  2012-03       Impact factor: 8.807

3.  Myosin II-actin interaction in MDCK cells: role in cell shape changes in response to Ca2+ variations.

Authors:  A M Castillo; R Lagunes; M Urban; E Frixione; I Meza
Journal:  J Muscle Res Cell Motil       Date:  1998-06       Impact factor: 2.698

4.  Protein phosphatase composition in the smooth muscle of guinea-pig ileum studied with okadaic acid and inhibitor 2.

Authors:  A Takai; M Troschka; G Mieskes; A V Somlyo
Journal:  Biochem J       Date:  1989-09-01       Impact factor: 3.857

Review 5.  The Molecular Basis of Toxins' Interactions with Intracellular Signaling via Discrete Portals.

Authors:  Adi Lahiani; Ephraim Yavin; Philip Lazarovici
Journal:  Toxins (Basel)       Date:  2017-03-16       Impact factor: 4.546

6.  Okadaic acid treatment leads to a fragmentation of the trans-Golgi network and an increase in expression of TGN38 at the cell surface.

Authors:  M Horn; G Banting
Journal:  Biochem J       Date:  1994-07-01       Impact factor: 3.857

7.  Induction of manganese superoxide dismutase mRNA by okadaic acid and protein synthesis inhibitors.

Authors:  J Fujii; T Nakata; E Miyoshi; Y Ikeda; N Taniguchi
Journal:  Biochem J       Date:  1994-07-01       Impact factor: 3.857

8.  Inhibition of specific binding of okadaic acid to protein phosphatase 2A by microcystin-LR, calyculin-A and tautomycin: method of analysis of interactions of tight-binding ligands with target protein.

Authors:  A Takai; K Sasaki; H Nagai; G Mieskes; M Isobe; K Isono; T Yasumoto
Journal:  Biochem J       Date:  1995-03-15       Impact factor: 3.857

9.  Regulation by cell volume of Na(+)-K(+)-2Cl- cotransport in vascular endothelial cells: role of protein phosphorylation.

Authors:  J D Klein; P B Perry; W C O'Neill
Journal:  J Membr Biol       Date:  1993-03       Impact factor: 1.843

10.  TPD1 of Saccharomyces cerevisiae encodes a protein phosphatase 2C-like activity implicated in tRNA splicing and cell separation.

Authors:  M K Robinson; W H van Zyl; E M Phizicky; J R Broach
Journal:  Mol Cell Biol       Date:  1994-06       Impact factor: 4.272
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