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Literature DB >> 2850164

Evidence for a nuclear factor(s), IRF-1, mediating induction and silencing properties to human IFN-beta gene regulatory elements.

T Fujita¹, J Sakakibara, Y Sudo, M Miyamoto, Y Kimura, T Taniguchi.

Abstract

Transcription of the human interferon-beta (IFN-beta) gene is induced by a variety of agents such as viruses, dsRNA and some cytokines. In this study, we describe a nuclear factor, termed interferon regulatory factor-1 (IRF-1), that is involved in the transcription of IFN-beta and possibly other genes. We demonstrate that IRF-1 functions in virus-induced transcription by interacting with previously identified, IFN-beta regulatory DNA elements. Our data suggest that IRF-1 participates in the transient formation of an induction-specific complex(es) with the regulatory elements. IRF-1 may also be involved in silencing the function of the SV40 enhancer juxtaposed to the regulatory elements in uninduced cells.

Entities: Chemical

Mesh：

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Year: 1988 PMID： 2850164 PMCID： PMC454838 DOI： 10.1002/j.1460-2075.1988.tb03213.x

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

34 in total

1. Intracytoplasmic phosphorylation sites of Tac antigen (p55) are not essential for the conformation, function, and regulation of the human interleukin 2 receptor.

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Journal: Proc Natl Acad Sci U S A Date: 1986-12 Impact factor: 11.205

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Journal: Nature Date: 1986 Jan 9-15 Impact factor: 49.962

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Journal: Annu Rev Immunol Date: 1988 Impact factor: 28.527

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Journal: Annu Rev Biochem Date: 1982 Impact factor: 23.643

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Authors: N Mantei; C Weissmann
Journal: Nature Date: 1982-05-13 Impact factor: 49.962

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Journal: Cell Date: 1987-01-30 Impact factor: 41.582

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Journal: Cell Date: 1987-09-25 Impact factor: 41.582

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Journal: Cell Date: 1985-06 Impact factor: 41.582

109 in total

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Authors: R Lin; P Génin; Y Mamane; J Hiscott
Journal: Mol Cell Biol Date: 2000-09 Impact factor: 4.272

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Authors: P H Driggers; D L Ennist; S L Gleason; W H Mak; M S Marks; B Z Levi; J R Flanagan; E Appella; K Ozato
Journal: Proc Natl Acad Sci U S A Date: 1990-05 Impact factor: 11.205

3. Docking-dependent ubiquitination of the interferon regulatory factor-1 tumor suppressor protein by the ubiquitin ligase CHIP.

Authors: Vikram Narayan; Emmanuelle Pion; Vivien Landré; Petr Müller; Kathryn L Ball
Journal: J Biol Chem Date: 2010-10-14 Impact factor: 5.157

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Authors: S E Grossberg; J L Taylor; V M Kushnaryov
Journal: Experientia Date: 1989-06-15

5. Induction of the transcription factor IRF-1 and interferon-beta mRNAs by cytokines and activators of second-messenger pathways.

Authors: T Fujita; L F Reis; N Watanabe; Y Kimura; T Taniguchi; J Vilcek
Journal: Proc Natl Acad Sci U S A Date: 1989-12 Impact factor: 11.205

6. Gene cloning and expression analysis of IRF1 in half-smooth tongue sole (Cynoglossus semilaevis).

Authors: Yang Lu; Qilong Wang; Yang Liu; Changwei Shao; Songlin Chen; Zhenxia Sha
Journal: Mol Biol Rep Date: 2014-03-01 Impact factor: 2.316

7. An atomic model of the interferon-beta enhanceosome.

Authors: Daniel Panne; Tom Maniatis; Stephen C Harrison
Journal: Cell Date: 2007-06-15 Impact factor: 41.582

8. Identification of multiple cis-elements and trans-acting factors involved in the induced expression of human IL-2 gene.

Authors: H Shibuya; T Taniguchi
Journal: Nucleic Acids Res Date: 1989-11-25 Impact factor: 16.971

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Authors: E Garoufalis; I Kwan; R Lin; A Mustafa; N Pepin; A Roulston; J Lacoste; J Hiscott
Journal: J Virol Date: 1994-08 Impact factor: 5.103

10. Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7.

Authors: I Marié; J E Durbin; D E Levy
Journal: EMBO J Date: 1998-11-16 Impact factor: 11.598