Chui Ming Gemmy Cheung1, Peng Guan Ong2, Kumari Neelam2, Pok Chien Tan2, Yuan Shi2, Paul Mitchell3, Jie Jin Wang3, Charumathi Sabanayagam1, Ching-Yu Cheng1, Tien Yin Wong4. 1. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Republic of Singapore; Department of Ophthalmology, National University of Singapore, Singapore, Republic of Singapore. 2. Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Republic of Singapore. 3. Centre for Vision Research, University of Sydney, Sydney, Australia. 4. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Republic of Singapore; Department of Ophthalmology, National University of Singapore, Singapore, Republic of Singapore. Electronic address: wong.tien.yin@singhealth.com.sg.
Abstract
PURPOSE: To determine the 6-year incidence of early and late age-related macular degeneration (AMD) in a Singaporean Malay population and to validate the Age-Related Eye Disease Study (AREDS) simplified severity scale in Asians. DESIGN: Prospective, population cohort study. PARTICIPANTS: The Singapore Malay Eye Study baseline participants (age, ≥40 years; 2006-2008) were followed up in 2011 through 2013, and 1901 of 3280 of eligible participants (72.1%) took part. METHODS: Fundus photographs were graded using the Wisconsin AMD grading system. MAIN OUTCOME MEASURES: Incidence of early and late AMD. RESULTS: Gradable fundus photographs were available for 1809 participants who attended both baseline and 6-year follow-up examinations. The age-standardized incidences of early and late AMD were 5.89% (95% confidence interval [CI], 4.81-7.16) and 0.76% (95% CI, 0.42-1.29), respectively. The 5-year age-standardized incidence of early AMD (calculated based on the 6-year incidence) was lower in our population (5.58%; 95% CI, 4.43-7.01) compared with the Beaver Dam Eye Study population (8.19%). The incidence of late AMD in our population was similar to that of the Beaver Dam Eye Study population (0.98% [95% CI, 0.49-1.86] vs. 0.91%), the Blue Mountains Eye Study population (1.10% [95% CI, 0.52-9.56] vs. 1.10%), and the Hisayama Study population (1.09% [95% CI, 0.54-4.25] vs. 0.84%). The incidence of late AMD increased markedly with increasing baseline AREDS score (step 0, 0.23%; step 4, 9.09%). CONCLUSIONS: This study documented the incidence of early and late AMD in a Malay population. The AREDS simplified severity scale is useful in predicting the risk of late AMD development in Asians.
PURPOSE: To determine the 6-year incidence of early and late age-related macular degeneration (AMD) in a Singaporean Malay population and to validate the Age-Related Eye Disease Study (AREDS) simplified severity scale in Asians. DESIGN: Prospective, population cohort study. PARTICIPANTS: The Singapore Malay Eye Study baseline participants (age, ≥40 years; 2006-2008) were followed up in 2011 through 2013, and 1901 of 3280 of eligible participants (72.1%) took part. METHODS: Fundus photographs were graded using the Wisconsin AMD grading system. MAIN OUTCOME MEASURES: Incidence of early and late AMD. RESULTS: Gradable fundus photographs were available for 1809 participants who attended both baseline and 6-year follow-up examinations. The age-standardized incidences of early and late AMD were 5.89% (95% confidence interval [CI], 4.81-7.16) and 0.76% (95% CI, 0.42-1.29), respectively. The 5-year age-standardized incidence of early AMD (calculated based on the 6-year incidence) was lower in our population (5.58%; 95% CI, 4.43-7.01) compared with the Beaver Dam Eye Study population (8.19%). The incidence of late AMD in our population was similar to that of the Beaver Dam Eye Study population (0.98% [95% CI, 0.49-1.86] vs. 0.91%), the Blue Mountains Eye Study population (1.10% [95% CI, 0.52-9.56] vs. 1.10%), and the Hisayama Study population (1.09% [95% CI, 0.54-4.25] vs. 0.84%). The incidence of late AMD increased markedly with increasing baseline AREDS score (step 0, 0.23%; step 4, 9.09%). CONCLUSIONS: This study documented the incidence of early and late AMD in a Malay population. The AREDS simplified severity scale is useful in predicting the risk of late AMD development in Asians.
Authors: Tien Yin Wong; Chui Ming Gemmy Cheung; Timothy Y Y Lai; Shih-Jen Chen; Won Ki Lee; Young Hee Yoon; Tomohiro Iida; Claudia Tueckmantel; Olaf Sowade; Yuichiro Ogura Journal: Retina Date: 2019-03 Impact factor: 4.256
Authors: Thomas J Heesterbeek; Eiko K de Jong; Ilhan E Acar; Joannes M M Groenewoud; Bart Liefers; Clara I Sánchez; Tunde Peto; Carel B Hoyng; Daniel Pauleikhoff; Hans W Hense; Anneke I den Hollander Journal: Sci Rep Date: 2019-04-29 Impact factor: 4.379
Authors: Nicholas Y Q Tan; Joel Chan; Ching-Yu Cheng; Tien Yin Wong; Charumathi Sabanayagam Journal: Front Endocrinol (Lausanne) Date: 2019-01-14 Impact factor: 5.555