Literature DB >> 28501300

A metabolite-GWAS (mGWAS) approach to unveil chronic kidney disease progression.

Guanshi Zhang1, Rintaro Saito1, Kumar Sharma2.   

Abstract

In this issue, McMahon et al. report that, by combining phenotypic, metabolomic, and genetic data, they could better detect chronic kidney disease at the early stages and provide insight into its pathobiology. The most significant findings of the study are that several urinary metabolites (e.g., glycine and histidine) were identified as early risk factors for chronic kidney disease, and metabolites with genomewide association study analysis identified associations of urinary metabolites (i.e., lysine and NG-monomethyl-l-arginine) with single-nucleotide polymorphisms of SLC7A9. Published by Elsevier Inc.

Entities:  

Mesh：

Year:  2017        PMID： 28501300      PMCID： PMC5989707          DOI： 10.1016/j.kint.2017.03.022

Source DB:  PubMed          Journal:  Kidney Int        ISSN： 0085-2538            Impact factor:   10.612


  9 in total

1.  A genome-wide association study of metabolic traits in human urine.

Authors:  Karsten Suhre; Henri Wallaschofski; Johannes Raffler; Nele Friedrich; Robin Haring; Kathrin Michael; Christina Wasner; Alexander Krebs; Florian Kronenberg; David Chang; Christa Meisinger; H-Erich Wichmann; Wolfgang Hoffmann; Henry Völzke; Uwe Völker; Alexander Teumer; Reiner Biffar; Thomas Kocher; Stephan B Felix; Thomas Illig; Heyo K Kroemer; Christian Gieger; Werner Römisch-Margl; Matthias Nauck
Journal:  Nat Genet       Date:  2011-05-15       Impact factor: 38.330

2.  Systems biology analysis reveals role of MDM2 in diabetic nephropathy.

Authors:  Rintaro Saito; Anaïs Rocanin-Arjo; Young-Hyun You; Manjula Darshi; Benjamin Van Espen; Satoshi Miyamoto; Jessica Pham; Minya Pu; Simone Romoli; Loki Natarajan; Wenjun Ju; Matthias Kretzler; Robert Nelson; Keiichiro Ono; Dana Thomasova; Shrikant R Mulay; Trey Ideker; Vivette D'Agati; Ergin Beyret; Juan Carlos Izpisua Belmonte; Hans Joachim Anders; Kumar Sharma
Journal:  JCI Insight       Date:  2016-10-20

3.  Urinary metabolites along with common and rare genetic variations are associated with incident chronic kidney disease.

Authors:  Gearoid M McMahon; Shih-Jen Hwang; Clary B Clish; Adrienne Tin; Qiong Yang; Martin G Larson; Eugene P Rhee; Man Li; Daniel Levy; Christopher J O'Donnell; Josef Coresh; J Hunter Young; Robert E Gerszten; Caroline S Fox
Journal:  Kidney Int       Date:  2017-03-14       Impact factor: 10.612

4.  Genomewide linkage analysis to serum creatinine, GFR, and creatinine clearance in a community-based population: the Framingham Heart Study.

Authors:  Caroline S Fox; Qiong Yang; L Adrienne Cupples; Chao-Yu Guo; Martin G Larson; Eric P Leip; Peter W F Wilson; Daniel Levy
Journal:  J Am Soc Nephrol       Date:  2004-09       Impact factor: 10.121

5.  Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker.

Authors:  Wenjun Ju; Viji Nair; Shahaan Smith; Li Zhu; Kerby Shedden; Peter X K Song; Laura H Mariani; Felix H Eichinger; Celine C Berthier; Ann Randolph; Jennifer Yi-Chun Lai; Yan Zhou; Jennifer J Hawkins; Markus Bitzer; Matthew G Sampson; Martina Thier; Corinne Solier; Gonzalo C Duran-Pacheco; Guillemette Duchateau-Nguyen; Laurent Essioux; Brigitte Schott; Ivan Formentini; Maria C Magnone; Maria Bobadilla; Clemens D Cohen; Serena M Bagnasco; Laura Barisoni; Jicheng Lv; Hong Zhang; Hai-Yan Wang; Frank C Brosius; Crystal A Gadegbeku; Matthias Kretzler
Journal:  Sci Transl Med       Date:  2015-12-02       Impact factor: 17.956

6.  Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease.

Authors:  Kumar Sharma; Bethany Karl; Anna V Mathew; Jon A Gangoiti; Christina L Wassel; Rintaro Saito; Minya Pu; Shoba Sharma; Young-Hyun You; Lin Wang; Maggie Diamond-Stanic; Maja T Lindenmeyer; Carol Forsblom; Wei Wu; Joachim H Ix; Trey Ideker; Jeffrey B Kopp; Sanjay K Nigam; Clemens D Cohen; Per-Henrik Groop; Bruce A Barshop; Loki Natarajan; William L Nyhan; Robert K Naviaux
Journal:  J Am Soc Nephrol       Date:  2013-10-10       Impact factor: 10.121

7.  A systems approach identifies HIPK2 as a key regulator of kidney fibrosis.

Authors:  Yuanmeng Jin; Krishna Ratnam; Peter Y Chuang; Ying Fan; Yifei Zhong; Yan Dai; Amin R Mazloom; Edward Y Chen; Vivette D'Agati; Huabao Xiong; Michael J Ross; Nan Chen; Avi Ma'ayan; John Cijiang He
Journal:  Nat Med       Date:  2012-03-11       Impact factor: 53.440

8.  Stability of targeted metabolite profiles of urine samples under different storage conditions.

Authors:  Markus Rotter; Stefan Brandmaier; Cornelia Prehn; Jonathan Adam; Sylvia Rabstein; Katarzyna Gawrych; Thomas Brüning; Thomas Illig; Heiko Lickert; Jerzy Adamski; Rui Wang-Sattler
Journal:  Metabolomics       Date:  2016-11-28       Impact factor: 4.290

9.  An atlas of genetic influences on human blood metabolites.

Authors:  So-Youn Shin; Eric B Fauman; Ann-Kristin Petersen; Jan Krumsiek; Rita Santos; Jie Huang; Matthias Arnold; Idil Erte; Vincenzo Forgetta; Tsun-Po Yang; Klaudia Walter; Cristina Menni; Lu Chen; Louella Vasquez; Ana M Valdes; Craig L Hyde; Vicky Wang; Daniel Ziemek; Phoebe Roberts; Li Xi; Elin Grundberg; Melanie Waldenberger; J Brent Richards; Robert P Mohney; Michael V Milburn; Sally L John; Jeff Trimmer; Fabian J Theis; John P Overington; Karsten Suhre; M Julia Brosnan; Christian Gieger; Gabi Kastenmüller; Tim D Spector; Nicole Soranzo
Journal:  Nat Genet       Date:  2014-05-11       Impact factor: 38.330
  9 in total
  3 in total

1.  Evaluation of Neutrophil Gelatinase-Associated Lipocalin and Cystatin C in Early Diagnosis of Chronic Kidney Disease in the Absence of the Gold Standard.

Authors:  Fatemeh Masaebi; Mehdi Azizmohammad Looha; Zhuoyu Wang; Elaheh Zarean; Malihe Nasiri; Faranak Kazerouni; Fatemeh Gharishvandi; Farid Zayeri
Journal:  Galen Med J       Date:  2020-06-22

2.  Integrative Pathway Analysis of SNP and Metabolite Data Using a Hierarchical Structural Component Model.

Authors:  Taeyeong Jung; Youngae Jung; Min Kyong Moon; Oran Kwon; Geum-Sook Hwang; Taesung Park
Journal:  Front Genet       Date:  2022-03-24       Impact factor: 4.599

3.  Genetic Regulation of Liver Metabolites and Transcripts Linking to Biochemical-Clinical Parameters.

Authors:  Siriluck Ponsuksili; Nares Trakooljul; Frieder Hadlich; Karen Methling; Michael Lalk; Eduard Murani; Klaus Wimmers
Journal:  Front Genet       Date:  2019-04-17       Impact factor: 4.599
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.