Literature DB >> 2850053

In vivo EDRF activity influences platelet function.

J C Hogan1, M J Lewis, A H Henderson.   

Abstract

The administration of carbachol to rabbits to stimulate the release of endothelium derived relaxing factor (EDRF) results in inhibition of platelet aggregation and elevation of platelet cyclic GMP content. These effects are reversed by simultaneous administration of the EDRF inhibitors methylene blue or haemoglobin. The data provide the first direct biochemical evidence of in vivo EDRF activity.

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Year:  1988        PMID： 2850053      PMCID： PMC1854093          DOI： 10.1111/j.1476-5381.1988.tb11616.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  9 in total

1.  Endothelium-derived relaxing factor inhibits in vitro platelet aggregation.

Authors:  B Furlong; A H Henderson; M J Lewis; J A Smith
Journal:  Br J Pharmacol       Date:  1987-04       Impact factor: 8.739

2.  Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates.

Authors:  L J Ignarro; H Lippton; J C Edwards; W H Baricos; A L Hyman; P J Kadowitz; C A Gruetter
Journal:  J Pharmacol Exp Ther       Date:  1981-09       Impact factor: 4.030

3.  Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta.

Authors:  W Martin; G M Villani; D Jothianandan; R F Furchgott
Journal:  J Pharmacol Exp Ther       Date:  1985-03       Impact factor: 4.030

Review 4.  The role of endothelium in the control of vascular tone.

Authors:  R Busse; G Trogisch; E Bassenge
Journal:  Basic Res Cardiol       Date:  1985 Sep-Oct       Impact factor: 17.165

5.  The nature of endothelium-derived vascular relaxant factor.

Authors:  T M Griffith; D H Edwards; M J Lewis; A C Newby; A H Henderson
Journal:  Nature       Date:  1984 Apr 12-18       Impact factor: 49.962

6.  Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP.

Authors:  R M Rapoport; F Murad
Journal:  Circ Res       Date:  1983-03       Impact factor: 17.367

7.  The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine.

Authors:  R F Furchgott; J V Zawadzki
Journal:  Nature       Date:  1980-11-27       Impact factor: 49.962

8.  Haptoglobin-haemoglobin complex in human plasma inhibits endothelium dependent relaxation: evidence that endothelium derived relaxing factor acts as a local autocoid.

Authors:  D H Edwards; T M Griffith; H C Ryley; A H Henderson
Journal:  Cardiovasc Res       Date:  1986-08       Impact factor: 10.787

9.  Release and properties of endothelium-derived relaxing factor (EDRF) from endothelial cells in culture.

Authors:  T M Cocks; J A Angus; J H Campbell; G R Campbell
Journal:  J Cell Physiol       Date:  1985-06       Impact factor: 6.384
  9 in total
  15 in total

Review 1.  St Cyres lecture. Endothelium in control.

Authors:  A H Henderson
Journal:  Br Heart J       Date:  1991-03

2.  Effect of molsidomine on ex vivo platelet aggregation and plasma guanosine 3':5'-cyclic monophosphate levels in healthy volunteers.

Authors:  B Karrenbrock; J M Heim; R Gerzer
Journal:  Klin Wochenschr       Date:  1990-02-15

Review 3.  Microvascular coronary dysfunction in women: pathophysiology, diagnosis, and management.

Authors:  Kamlesh Kothawade; C Noel Bairey Merz
Journal:  Curr Probl Cardiol       Date:  2011-08       Impact factor: 5.200

4.  Endogenous nitric oxide as a modulator of rabbit skeletal muscle microcirculation in vivo.

Authors:  M G Persson; L E Gustafsson; N P Wiklund; P Hedqvist; S Moncada
Journal:  Br J Pharmacol       Date:  1990-07       Impact factor: 8.739

5.  Inhibition of superoxide anion release from circulating neutrophils by L-arginine in man.

Authors:  C J Wiedermann; B Sitte; U Zilian; N Reinisch; H Beimpold; G Finkenstedt; H Braunsteiner
Journal:  Clin Investig       Date:  1993-12

6.  Comparison of the effects of isobutylmethylxanthine and milrinone on ischaemia-induced arrhythmias and platelet aggregation in anaesthetized rabbits.

Authors:  M Holbrook; S J Coker
Journal:  Br J Pharmacol       Date:  1989-09       Impact factor: 8.739

7.  Glyceryl trinitrate and platelet aggregation: effects of N-acetyl-cysteine.

Authors:  J C Hogan; M J Lewis; A H Henderson
Journal:  Br J Clin Pharmacol       Date:  1989-05       Impact factor: 4.335

8.  Regional heterogeneity of endothelium-dependent vasodilatation in the rabbit kidney.

Authors:  H S Cairns; M E Rogerson; J Westwick; G H Neild
Journal:  J Physiol       Date:  1991-05       Impact factor: 5.182

9.  The effect of endothelium-derived nitric oxide on ex vivo whole blood platelet aggregation in man.

Authors:  P Vallance; N Benjamin; J Collier
Journal:  Eur J Clin Pharmacol       Date:  1992       Impact factor: 2.953

10.  Effects of zaprinast and rolipram on platelet aggregation and arrhythmias following myocardial ischaemia and reperfusion in anaesthetized rabbits.

Authors:  M Holbrook; S J Coker
Journal:  Br J Pharmacol       Date:  1991-08       Impact factor: 8.739
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