Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The structure of V alpha and J alpha segments in the mouse.

Literature DB >> 2849763

The structure of V alpha and J alpha segments in the mouse.

J Yague¹, M Blackman, W Born, P Marrack, J Kappler, E Palmer.

Abstract

Antigen receptors on most T-cells are heterodimeric glycoproteins, comprised of an alpha chain and a beta chain. These chains are encoded by discontiguous variable (V), diversity (D) and joining (J) gene segments that rearrange to produce a contiguous and functional alpha or beta chain gene. To investigate the size and diversity of the germline repertoire of alpha-chain gene segments, we have characterized and sequenced 20 alpha chain cDNAs. Among these cDNA clones, we have found 4 J alpha and 4 V alpha sequences that have not yet been described. The relationship of these "new" gene segments to those already characterized is discussed.

Entities: Gene Species

Mesh：

Substances：

Year: 1988 PMID： 2849763 PMCID： PMC339015 DOI： 10.1093/nar/16.23.11355

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

35 in total

1. Rearrangement and transcription of the beta-chain genes of the T-cell antigen receptor in different types of murine lymphocytes.

Authors: M Kronenberg; J Goverman; R Haars; M Malissen; E Kraig; L Phillips; T Delovitch; N Suciu-Foca; L Hood
Journal: Nature Date: 1985 Feb 21-27 Impact factor: 49.962

2. Rearrangement of T-cell receptor beta-chain genes during T-cell development.

Authors: W Born; J Yagüe; E Palmer; J Kappler; P Marrack
Journal: Proc Natl Acad Sci U S A Date: 1985-05 Impact factor: 11.205

3. Localization of a T-cell receptor diversity-region element.

Authors: J Kavaler; M M Davis; Y Chien
Journal: Nature Date: 1984 Aug 2-8 Impact factor: 49.962

4. Structure, expression and divergence of T-cell receptor beta-chain variable regions.

Authors: P Patten; T Yokota; J Rothbard; Y Chien; K Arai; M M Davis
Journal: Nature Date: 1984 Nov 1-7 Impact factor: 49.962

5. The structure, rearrangement and expression of D beta gene segments of the murine T-cell antigen receptor.

Authors: G Siu; M Kronenberg; E Strauss; R Haars; T W Mak; L Hood
Journal: Nature Date: 1984 Sep 27-Oct 3 Impact factor: 49.962

6. A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes.

Authors: H Saito; D M Kranz; Y Takagaki; A C Hayday; H N Eisen; S Tonegawa
Journal: Nature Date: 1984 Nov 1-7 Impact factor: 49.962

7. Genomic organization and sequence of T-cell receptor beta-chain constant- and joining-region genes.

Authors: N R Gascoigne; Y Chien; D M Becker; J Kavaler; M M Davis
Journal: Nature Date: 1984 Aug 2-8 Impact factor: 49.962

8. A third type of murine T-cell receptor gene.

Authors: Y Chien; D M Becker; T Lindsten; M Okamura; D I Cohen; M M Davis
Journal: Nature Date: 1984 Nov 1-7 Impact factor: 49.962

9. pEMBL: a new family of single stranded plasmids.

Authors: L Dente; G Cesareni; R Cortese
Journal: Nucleic Acids Res Date: 1983-03-25 Impact factor: 16.971

10. The T cell receptor beta chain genes are located on chromosome 6 in mice and chromosome 7 in humans.

Authors: N Caccia; M Kronenberg; D Saxe; R Haars; G A Bruns; J Goverman; M Malissen; H Willard; Y Yoshikai; M Simon
Journal: Cell Date: 1984-07 Impact factor: 41.582

20 in total

1. Diversity of T-cell receptors in virus-specific cytotoxic T lymphocytes recognizing three distinct viral epitopes restricted by a single major histocompatibility complex molecule.

Authors: Y Yanagi; A Tishon; H Lewicki; B A Cubitt; M B Oldstone
Journal: J Virol Date: 1992-04 Impact factor: 5.103

2. The presumptive CDR3 regions of both T cell receptor alpha and beta chains determine T cell specificity for myoglobin peptides.

Authors: J S Danska; A M Livingstone; V Paragas; T Ishihara; C G Fathman
Journal: J Exp Med Date: 1990-07-01 Impact factor: 14.307

The structure of V alpha and J alpha segments in the mouse.

1. Rearrangement and transcription of the beta-chain genes of the T-cell antigen receptor in different types of murine lymphocytes.

2. Rearrangement of T-cell receptor beta-chain genes during T-cell development.

3. Localization of a T-cell receptor diversity-region element.

4. Structure, expression and divergence of T-cell receptor beta-chain variable regions.

5. The structure, rearrangement and expression of D beta gene segments of the murine T-cell antigen receptor.

6. A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes.

7. Genomic organization and sequence of T-cell receptor beta-chain constant- and joining-region genes.

8. A third type of murine T-cell receptor gene.

9. pEMBL: a new family of single stranded plasmids.

10. The T cell receptor beta chain genes are located on chromosome 6 in mice and chromosome 7 in humans.

1. Diversity of T-cell receptors in virus-specific cytotoxic T lymphocytes recognizing three distinct viral epitopes restricted by a single major histocompatibility complex molecule.

2. The presumptive CDR3 regions of both T cell receptor alpha and beta chains determine T cell specificity for myoglobin peptides.

Review 3. Alpha beta T-lymphocyte depleted mice, a model for gamma delta T-lymphocyte functional studies.

4. Characterization of the mouse Tcra-V22 gene subfamily.

5. Identification of rat Tcra-V 4 and 8 gene products by monoclonal antibodies and cDNA sequence.

6. Binding of a soluble alpha beta T-cell receptor to superantigen/major histocompatibility complex ligands.

7. Islet-specific T-cell clones from nonobese diabetic mice express heterogeneous T-cell receptors.

8. Multiplicity of virus-encoded helper T-cell epitopes expressed on FBL-3 tumor cells.

9. Structural analysis of the rat T-cell receptor Tcra V4 gene family.

10. Subgroups of Tcr alpha chains and correlation with T-cell function.