Anne-Sophie Jannot1, Eric Zapletal2, Paul Avillach3, Marie-France Mamzer4, Anita Burgun5, Patrice Degoulet5. 1. Paris Descartes Faculty of Medicine, Paris, France; INSERM UMR 1138-E22: Information Sciences to Support Personalized Medicine, Paris, France; Medical Informatics, Biostatistics and Public Health Department, Georges Pompidou University Hospital, Paris, France. Electronic address: annesophie.jannot@aphp.fr. 2. Medical Informatics, Biostatistics and Public Health Department, Georges Pompidou University Hospital, Paris, France. 3. Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. 4. Paris Descartes Faculty of Medicine, Paris, France; INSERM EA 4569 Medical Ethics Department. 5. Paris Descartes Faculty of Medicine, Paris, France; INSERM UMR 1138-E22: Information Sciences to Support Personalized Medicine, Paris, France; Medical Informatics, Biostatistics and Public Health Department, Georges Pompidou University Hospital, Paris, France.
Abstract
BACKGROUND: When developed jointly with clinical information systems, clinical data warehouses (CDWs) facilitate the reuse of healthcare data and leverage clinical research. OBJECTIVE: To describe both data access and use for clinical research, epidemiology and health service research of the "Hôpital Européen Georges Pompidou" (HEGP) CDW. METHODS: The CDW has been developed since 2008 using an i2b2 platform. It was made available to health professionals and researchers in October 2010. Procedures to access data have been implemented and different access levels have been distinguished according to the nature of queries. RESULTS: As of July 2016, the CDW contained the consolidated data of over 860,000 patients followed since the opening of the HEGP hospital in July 2000. These data correspond to more than 122 million clinical item values, 124 million biological item values, and 3.7 million free text reports. The ethics committee of the hospital evaluates all CDW projects that generate secondary data marts. Characteristics of the 74 research projects validated between January 2011 and December 2015 are described. CONCLUSION: The use of HEGP CDWs is a key facilitator for clinical research studies. It required however important methodological and organizational support efforts from a biomedical informatics department.
BACKGROUND: When developed jointly with clinical information systems, clinical data warehouses (CDWs) facilitate the reuse of healthcare data and leverage clinical research. OBJECTIVE: To describe both data access and use for clinical research, epidemiology and health service research of the "Hôpital Européen Georges Pompidou" (HEGP) CDW. METHODS: The CDW has been developed since 2008 using an i2b2 platform. It was made available to health professionals and researchers in October 2010. Procedures to access data have been implemented and different access levels have been distinguished according to the nature of queries. RESULTS: As of July 2016, the CDW contained the consolidated data of over 860,000 patients followed since the opening of the HEGP hospital in July 2000. These data correspond to more than 122 million clinical item values, 124 million biological item values, and 3.7 million free text reports. The ethics committee of the hospital evaluates all CDW projects that generate secondary data marts. Characteristics of the 74 research projects validated between January 2011 and December 2015 are described. CONCLUSION: The use of HEGP CDWs is a key facilitator for clinical research studies. It required however important methodological and organizational support efforts from a biomedical informatics department.
Authors: Sandrine Boulet; Moreno Ursino; Peter Thall; Bruno Landi; Céline Lepère; Simon Pernot; Anita Burgun; Julien Taieb; Aziz Zaanan; Sarah Zohar; Anne-Sophie Jannot Journal: Stat Methods Med Res Date: 2019-04-09 Impact factor: 2.494
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