Literature DB >> 2849377

Mechanism of action of the antiviral compound MDL 20,610.

M T Kenny1, H L Torney, J K Dulworth.   

Abstract

The purpose of this study was to probe the antirhinovirus (RV) mechanism of action of MDL 20,610. Evaluation of the compound's effects on RV RNA synthesis, uncoating of neutral red-sensitized RV, plasma membrane penetration by RV, stabilization of RV against heat (56 degrees C) and low pH (5.0) inactivation, and studies with MDL 20,610-resistant RV mutants indicate that MDL 20,610 binds directly to the RV capsid with subsequent inhibition of acid-mediated virion uncoating.

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Year:  1988        PMID： 2849377      PMCID： PMC7133839          DOI： 10.1016/0166-3542(88)90056-3

Source DB:  PubMed          Journal:  Antiviral Res        ISSN： 0166-3542            Impact factor:   5.970


  22 in total

1.  Studies of rhinovirus resistant to an antiviral chalcone.

Authors:  A L Ahmad; A B Dowsett; D A Tyrrell
Journal:  Antiviral Res       Date:  1987-08       Impact factor: 5.970

2.  The site of attachment in human rhinovirus 14 for antiviral agents that inhibit uncoating.

Authors:  T J Smith; M J Kremer; M Luo; G Vriend; E Arnold; G Kamer; M G Rossmann; M A McKinlay; G D Diana; M J Otto
Journal:  Science       Date:  1986-09-19       Impact factor: 47.728

3.  The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice.

Authors:  H J Field; P Wildy
Journal:  J Hyg (Lond)       Date:  1978-10

4.  Effect of dichloroflavan (BW683C) on the stability and uncoating of rhinovirus type 1B.

Authors:  M Tisdale; J W Selway
Journal:  J Antimicrob Chemother       Date:  1984-08       Impact factor: 5.790

5.  WIN 51711, a new systematically active broad-spectrum antipicornavirus agent.

Authors:  M A McKinlay
Journal:  J Antimicrob Chemother       Date:  1985-09       Impact factor: 5.790

6.  Antiviral activity and mechanism of action of 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile (MDL-860).

Authors:  H L Torney; J K Dulworth; D L Steward
Journal:  Antimicrob Agents Chemother       Date:  1982-10       Impact factor: 5.191

7.  Pathogenicity in mice of strains of herpes simplex virus which are resistant to acyclovir in vitro and in vivo.

Authors:  H J Field; G Darby
Journal:  Antimicrob Agents Chemother       Date:  1980-02       Impact factor: 5.191

8.  Pathogenesis of experimental skin infections induced by drug-resistant herpes simplex virus mutants.

Authors:  R J Klein; A E Friedman-Kien; E DeStefano
Journal:  Infect Immun       Date:  1981-12       Impact factor: 3.441

9.  In vitro activity of WIN 51711, a new broad-spectrum antipicornavirus drug.

Authors:  M J Otto; M P Fox; M J Fancher; M F Kuhrt; G D Diana; M A McKinlay
Journal:  Antimicrob Agents Chemother       Date:  1985-06       Impact factor: 5.191

10.  Antivirus agent, Ro 09-0410, binds to rhinovirus specifically and stabilizes the virus conformation.

Authors:  Y Ninomiya; C Ohsawa; M Aoyama; I Umeda; Y Suhara; H Ishitsuka
Journal:  Virology       Date:  1984-04-30       Impact factor: 3.616
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  5 in total

1.  Binding affinities of structurally related human rhinovirus capsid-binding compounds are related to their activities against human rhinovirus type 14.

Authors:  M P Fox; M A McKinlay; G D Diana; F J Dutko
Journal:  Antimicrob Agents Chemother       Date:  1991-06       Impact factor: 5.191

2.  Lack of quantitative correlation between inhibition of replication of rhinoviruses by an antiviral drug and their stabilization.

Authors:  K Andries; B Dewindt; J Snoeks; R Willebrords
Journal:  Arch Virol       Date:  1989       Impact factor: 2.574

3.  6-(3,4-Dichlorophenoxy)-3-(ethylthio)-2-pyridincarbonitrile inhibits poliovirus uncoating.

Authors:  M E González; M J Almela; M Yacout; L Carrasco
Journal:  Antimicrob Agents Chemother       Date:  1990-06       Impact factor: 5.191

4.  Study of the parameters of binding of R 61837 to human rhinovirus 9 and immunobiochemical evidence of capsid-stabilizing activity of the compound.

Authors:  M Moeremans; M De Raeymaeker; G Daneels; M De Brabander; F Aerts; C Janssen; K Andries
Journal:  Antimicrob Agents Chemother       Date:  1992-02       Impact factor: 5.191

Review 5.  Picornavirus inhibitors.

Authors:  L Carrasco
Journal:  Pharmacol Ther       Date:  1994       Impact factor: 12.310
  5 in total

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