Literature DB >> 2168147

6-(3,4-Dichlorophenoxy)-3-(ethylthio)-2-pyridincarbonitrile inhibits poliovirus uncoating.

M E González1, M J Almela, M Yacout, L Carrasco.   

Abstract

We investigated the mode of action of 6-(3,4-dichlorophenoxy-3-(ethylthio)-2-pyridincarbonitrile against poliovirus. This agent effectively blocked the synthesis of poliovirus proteins and RNA when it was added at the beginning of infection. Poliovirus attachment and internalization into HeLa cells were not inhibited in the presence of the compound; poliovirus uncoating was the target of its activity.

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Year:  1990        PMID： 2168147      PMCID： PMC171796          DOI： 10.1128/AAC.34.6.1259

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  Early processes of echovirus 12-infection: elution, penetration, and uncoating under the influence of rhodanine.

Authors:  B Rosenwirth; H J Eggers
Journal:  Virology       Date:  1979-09       Impact factor: 3.616

2.  Prevention of rhinovirus and poliovirus uncoating by WIN 51711, a new antiviral drug.

Authors:  M P Fox; M J Otto; M A McKinlay
Journal:  Antimicrob Agents Chemother       Date:  1986-07       Impact factor: 5.191

Review 3.  Inhibitors of picornavirus uncoating as antiviral agents.

Authors:  G D Diana; M J Otto; M A McKinlay
Journal:  Pharmacol Ther       Date:  1985       Impact factor: 12.310

Review 4.  Modification of membrane permeability by animal viruses.

Authors:  L Carrasco; M J Otero; J L Castrillo
Journal:  Pharmacol Ther       Date:  1989       Impact factor: 12.310

5.  Antiviral activity and mechanism of action of 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile (MDL-860).

Authors:  H L Torney; J K Dulworth; D L Steward
Journal:  Antimicrob Agents Chemother       Date:  1982-10       Impact factor: 5.191

6.  Activity of 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile (MDL-860) against picornaviruses in vitro.

Authors:  R D Powers; J M Gwaltney; F G Hayden
Journal:  Antimicrob Agents Chemother       Date:  1982-10       Impact factor: 5.191

7.  3-Methylquercetin is a potent and selective inhibitor of poliovirus RNA synthesis.

Authors:  J L Castrillo; D Vanden Berghe; L Carrasco
Journal:  Virology       Date:  1986-07-15       Impact factor: 3.616

8.  In vitro and in vivo antipicornavirus activity of some phenoxypyridinecarbonitriles.

Authors:  M T Kenny; J K Dulworth; H L Torney
Journal:  Antimicrob Agents Chemother       Date:  1985-12       Impact factor: 5.191

9.  In vitro activity of WIN 51711, a new broad-spectrum antipicornavirus drug.

Authors:  M J Otto; M P Fox; M J Fancher; M F Kuhrt; G D Diana; M A McKinlay
Journal:  Antimicrob Agents Chemother       Date:  1985-06       Impact factor: 5.191

10.  Antivirus agent, Ro 09-0410, binds to rhinovirus specifically and stabilizes the virus conformation.

Authors:  Y Ninomiya; C Ohsawa; M Aoyama; I Umeda; Y Suhara; H Ishitsuka
Journal:  Virology       Date:  1984-04-30       Impact factor: 3.616
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  2 in total

1.  Inhibitors of poliovirus uncoating efficiently block the early membrane permeabilization induced by virus particles.

Authors:  M J Almela; M E González; L Carrasco
Journal:  J Virol       Date:  1991-05       Impact factor: 5.103

Review 2.  Picornavirus inhibitors.

Authors:  L Carrasco
Journal:  Pharmacol Ther       Date:  1994       Impact factor: 12.310
  2 in total

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