N Üçeyler1, M Burgmer2, E Friedel3, W Greiner4, F Petzke5, M Sarholz6, M Schiltenwolf7, A Winkelmann8, C Sommer9, W Häuser10,11. 1. Neurologische Klinik, Universitätsklinikum Würzburg, Würzburg, Deutschland. ueceyler_n@ukw.de. 2. Klinik für Psychosomatik und Psychotherapie, Universitätsklinikum Münster, Münster, Deutschland. 3. Medis Research GmbH, Bad Kissingen, Deutschland. 4. Psychosomatische und Psychoonkologische Tagesklinik, Universitätsklinikum Jena, Jena, Deutschland. 5. Schmerzmedizin, Klinik für Anästhesiologie, Universitätsmedizin Göttingen, Göttingen, Deutschland. 6. Rheumazentrum Ruhrgebiet, Herne, Deutschland. 7. Sektion konservative Orthopädie, Zentrum für Orthopädie, Unfallchirurgie und Paraplegiologie, Universitätsklinikum Heidelberg, Heidelberg, Deutschland. 8. Klinik und Poliklinik für Orthopädie, Physikalische Medizin und Rehabilitation, Klinikum der Universität München, München, Deutschland. 9. Neurologische Klinik, Universitätsklinikum Würzburg, Würzburg, Deutschland. 10. Innere Medizin I, Klinikum Saarbrücken gGmbH, Saarbrücken, Deutschland. 11. Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie, Technische Universität München, München, Deutschland.
Abstract
BACKGROUND: The regular update of the guidelines on fibromyalgia syndrome, AWMF number 145/004, was planned for April 2017. METHODS: The guidelines were developed by 13 scientific societies and 2 patient self-help organizations coordinated by the German Pain Society. Working groups (n =8) with a total of 42 members were formed balanced with respect to gender, medical expertise, position in the medical or scientific hierarchy and potential conflicts of interest. A systematic search of the literature from December 2010 to May 2016 was performed in the Cochrane library, MEDLINE, PsycINFO and Scopus databases. Prospective population-based studies and systematic reviews with meta-analyses of case control studies were taken into consideration for the statements. Levels of evidence were assigned according to the classification system of the Oxford Centre for Evidence-Based Medicine version 2009. The statements were generated by multiple step formalized procedures. The guidelines were reviewed and approved by the board of directors of the societies engaged in the development of the guidelines. RESULTS: Current data do not enable identification of distinct factors in the etiology and pathophysiology of fibromyalgia syndrome. Fibromyalgia syndrome can be associated with inflammatory rheumatic diseases, gene polymorphisms, life style factors (e.g. smoking, obesity and lack of physical activity), depressive disorders as well as physical and sexual abuse in childhood and adulthood. CONCLUSION: Fibromyalgia syndrome is most probably the end result of various pathogenetic factors and pathophysiological mechanisms.
BACKGROUND: The regular update of the guidelines on fibromyalgia syndrome, AWMF number 145/004, was planned for April 2017. METHODS: The guidelines were developed by 13 scientific societies and 2 patient self-help organizations coordinated by the German Pain Society. Working groups (n =8) with a total of 42 members were formed balanced with respect to gender, medical expertise, position in the medical or scientific hierarchy and potential conflicts of interest. A systematic search of the literature from December 2010 to May 2016 was performed in the Cochrane library, MEDLINE, PsycINFO and Scopus databases. Prospective population-based studies and systematic reviews with meta-analyses of case control studies were taken into consideration for the statements. Levels of evidence were assigned according to the classification system of the Oxford Centre for Evidence-Based Medicine version 2009. The statements were generated by multiple step formalized procedures. The guidelines were reviewed and approved by the board of directors of the societies engaged in the development of the guidelines. RESULTS: Current data do not enable identification of distinct factors in the etiology and pathophysiology of fibromyalgia syndrome. Fibromyalgia syndrome can be associated with inflammatory rheumatic diseases, gene polymorphisms, life style factors (e.g. smoking, obesity and lack of physical activity), depressive disorders as well as physical and sexual abuse in childhood and adulthood. CONCLUSION:Fibromyalgia syndrome is most probably the end result of various pathogenetic factors and pathophysiological mechanisms.
Entities:
Keywords:
Fibromyalgia syndrome; Guidelines; Pathophysiology; Review, systematic; Small fiber pathology
Authors: C Sommer; W Häuser; M Burgmer; R Engelhardt; K Gerhold; F Petzke; T Schmidt-Wilcke; M Späth; T Tölle; N Uçeyler; H Wang; A Winkelmann; K Thieme Journal: Schmerz Date: 2012-06 Impact factor: 1.107
Authors: Mahboobeh Dehghan; Tobias Schmidt-Wilcke; Bettina Pfleiderer; Simon B Eickhoff; Frank Petzke; Richard E Harris; Pedro Montoya; Markus Burgmer Journal: Hum Brain Mapp Date: 2016-02-11 Impact factor: 5.038
Authors: F Petzke; W Brückle; U Eidmann; P Heldmann; V Köllner; T Kühn; H Kühn-Becker; M Strunk-Richter; M Schiltenwolf; M Settan; M von Wachter; M Weigl; W Häuser Journal: Schmerz Date: 2017-06 Impact factor: 1.107
Authors: Hannah Waleed Haddad; Nikita Reddy Mallepalli; John Emerson Scheinuk; Pranav Bhargava; Elyse M Cornett; Ivan Urits; Alan David Kaye Journal: Pain Ther Date: 2021-04-28
Authors: Julian A Stewart; Simone Mailler-Burch; Darius Müller; Martina Studer; Roland von Känel; Martin Grosse Holtforth; Kyrill Schwegler; Niklaus Egloff Journal: J Pain Res Date: 2019-07-10 Impact factor: 3.133