Rabia Ghafoor1, Muhammad Irfan Anwar2. 1. Department of Dermatology, Jinnah Postgraduate Medical Centre, Karachi. 2. Department of Dermatology, PNS Shifa, Karachi.
Abstract
OBJECTIVE: To compare the mean Vitamin D level in patients with alopecia areata (AA) with age and gender controlled matched healthy controls. STUDY DESIGN: Case-control study. PLACE AND DURATION OF STUDY: Dermatology OPD, JPMC, from October 2014 to March 2015. METHODOLOGY: All the patients diagnosed of alopecia areata by a trained dermatologist were selected. Controls were age and gender matched healthy volunteers. Venous blood was drawn and sent to hospital laboratory for 25 (OH) vitamin D by enzyme immunoassay method on chemical analyser. Data was recorded on SPSS version 16. Mann-Whitney test was applied to compare vitamin D levels of cases and controls. P-value <0.05 was taken as significant. RESULTS: There are 30 cases of AA, and 30 age and gender matched controls. The mean age of our study group was 23.77 ±8.86 ng/dL in patients and 24.03 ±8.62 ng/dL in the control group. Fifteen (50%) patients presented between 3-12 months of onset of AA. Median (IQR) vitamin D level of cases was 13.5 (18.6) ng/dL and healthy controls was 22.5 (16.25) (p=0.001). CONCLUSION: Serum Vitamin D levels were significantly lower in patients with alopecia areata compared to healthy controls.
OBJECTIVE: To compare the mean Vitamin D level in patients with alopecia areata (AA) with age and gender controlled matched healthy controls. STUDY DESIGN: Case-control study. PLACE AND DURATION OF STUDY: Dermatology OPD, JPMC, from October 2014 to March 2015. METHODOLOGY: All the patients diagnosed of alopecia areata by a trained dermatologist were selected. Controls were age and gender matched healthy volunteers. Venous blood was drawn and sent to hospital laboratory for 25 (OH) vitamin D by enzyme immunoassay method on chemical analyser. Data was recorded on SPSS version 16. Mann-Whitney test was applied to compare vitamin D levels of cases and controls. P-value <0.05 was taken as significant. RESULTS: There are 30 cases of AA, and 30 age and gender matched controls. The mean age of our study group was 23.77 ±8.86 ng/dL in patients and 24.03 ±8.62 ng/dL in the control group. Fifteen (50%) patients presented between 3-12 months of onset of AA. Median (IQR) vitamin D level of cases was 13.5 (18.6) ng/dL and healthy controls was 22.5 (16.25) (p=0.001). CONCLUSION: Serum Vitamin D levels were significantly lower in patients with alopecia areata compared to healthy controls.
Authors: Felix Paolo J Lizarondo; Mia Katrina R Gervasio; Charmaine Vanessa S Chamberlin; Charissa Mia S Gnilo; Claudine Y Silva Journal: JAAD Int Date: 2021-09-20