| Literature DB >> 28490172 |
Seung Mok Ryu, Hae Min Lee1, Eun Gyeong Song1, Young Hye Seo2,3, Jun Lee2,3, Yuanqiang Guo4, Beom Seok Kim, Jae-Jin Kim, Jin Sung Hong5, Ki Hyun Ryu1, Dongho Lee.
Abstract
A bioassay-guided isolation using a green fluorescence protein (GFP)-tagged pepper mottle virus (PepMoV-GFP) based leaf-disk method to obtain new antiviral agents led to the isolation of trichodermin, 1, and a new compound trichoderminol, 2, from EtOAc extract of Trichoderma albolutescens culture medium. The structures of compounds 1 and 2 were determined by MS and NMR experiments, and the absolute configurations of the compounds were established by experimental and calculated vibrational circular dichroism spectra. Compounds 1 and 2 were evaluated for their anti-PepMoV potential in systemic host plants, such as tobacco and pepper, by PepMoV-GFP based systemic host method. All compounds exhibited inactivation effects against PepMoV. Furthermore, compound 1 showed protective effects against PepMoV.Entities:
Keywords: Capsicum annuum; Nicotiana benthamiana; Trichoderma albolutescens; antiviral agent; pepper mottle virus; trichothecene; vibrational circular dichroism
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Year: 2017 PMID： 28490172 DOI： 10.1021/acs.jafc.7b01028
Source DB: PubMed Journal: J Agric Food Chem ISSN： 0021-8561 Impact factor: 5.279