Literature DB >> 2848445

Transposon-mediated amikacin resistance in Klebsiella pneumoniae.

M E Tolmasky1, R M Chamorro, J H Crosa, P M Marini.   

Abstract

A multiresistant Klebsiella pneumoniae strain isolated from neonates in Mendoza, Argentina, harbored a 48-kilobase-pair (kbp) plasmid, pMET1, with genetic determinants for resistance to amikacin and also ampicillin, kanamycin, streptomycin, and tobramycin. This plasmid was compared with pJHCMW1, a previously isolated 11-kbp plasmid carrying transposon Tn1331, which encodes resistance to amikacin, as well as ampicillin, kanamycin, streptomycin, and tobramycin, and which was originally present in a K. pneumoniae strain that caused an outbreak in a hospital in Buenos Aires, Argentina. The comparison demonstrated that the replication regions of the two plasmids are unrelated. However, in pMET1 an 11-kbp transposition element, Tn1331.2, was identified; it was closely related to Tn1331, with the difference that a 3-kbp BamHI DNA fragment carrying the aminoglycoside resistance genes was duplicated in tandem.

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Year:  1988        PMID： 2848445      PMCID： PMC175879          DOI： 10.1128/AAC.32.9.1416

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  28 in total

1.  Conjugational behaviour of N plasmids in Escherichia coli K12.

Authors:  S Dennison; S Baumberg
Journal:  Mol Gen Genet       Date:  1975-07-10

2.  Cloning, isolation, and characterization of replication regions of complex plasmid genomes.

Authors:  K Timmis; F Cabello; S N Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  1975-06       Impact factor: 11.205

3.  Aminoglycoside-modifying enzymes.

Authors:  M J Haas; J E Dowding
Journal:  Methods Enzymol       Date:  1975       Impact factor: 1.600

4.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

5.  Sequencing and expression of the 6'-N-acetyltransferase gene of transposon Tn1331 from Klebsiella pneumoniae.

Authors:  K Nobuta; M E Tolmasky; L M Crosa; J H Crosa
Journal:  J Bacteriol       Date:  1988-08       Impact factor: 3.490

6.  Construction and characterization of new cloning vehicles. III. Derivatives of plasmid pBR322 carrying unique Eco RI sites for selection of Eco RI generated recombinant DNA molecules.

Authors:  F Bolivar
Journal:  Gene       Date:  1978-10       Impact factor: 3.688

Review 7.  Plasmid-determined resistance to antimicrobial agents.

Authors:  J Davies; D I Smith
Journal:  Annu Rev Microbiol       Date:  1978       Impact factor: 15.500

8.  Repetition of tetracycline resistance determinant genes on R plasmid pRSD1 in Escherichia coli.

Authors:  R Mattes; H J Burkardt; R Schmitt
Journal:  Mol Gen Genet       Date:  1979-01-10

9.  A complementation analysis of the restriction and modification of DNA in Escherichia coli.

Authors:  H W Boyer; D Roulland-Dussoix
Journal:  J Mol Biol       Date:  1969-05-14       Impact factor: 5.469

10.  Properties of an R plasmid in Pseudomonas aeruginosa producing amikacin (BB-K8), butirosin, kanamycin, tobramycin, and sisomicin resistance.

Authors:  G A Jacoby
Journal:  Antimicrob Agents Chemother       Date:  1974-12       Impact factor: 5.191
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  19 in total

1.  Systematic analysis of a conserved region of the aminoglycoside 6'-N-acetyltransferase type Ib.

Authors:  A Shmara; N Weinsetel; K J Dery; R Chavideh; M E Tolmasky
Journal:  Antimicrob Agents Chemother       Date:  2001-12       Impact factor: 5.191

2.  Clonality and antimicrobial resistance gene profiles of multidrug- resistant Salmonella enterica serovar infantis isolates from four public hospitals in Rio de Janeiro, Brazil.

Authors:  E L Fonseca; O L Mykytczuk; M D Asensi; E M F Reis; L R Ferraz; F L Paula; L K Ng; D P Rodrigues
Journal:  J Clin Microbiol       Date:  2006-08       Impact factor: 5.948

Review 3.  Aminoglycoside modifying enzymes.

Authors:  Maria S Ramirez; Marcelo E Tolmasky
Journal:  Drug Resist Updat       Date:  2010-09-15       Impact factor: 18.500

4.  Plasmid-Mediated Antibiotic Resistance and Virulence in Gram-negatives: the Klebsiella pneumoniae Paradigm.

Authors:  Maria S Ramirez; German M Traglia; David L Lin; Tung Tran; Marcelo E Tolmasky
Journal:  Microbiol Spectr       Date:  2014

5.  External guide sequences targeting the aac(6')-Ib mRNA induce inhibition of amikacin resistance.

Authors:  Alfonso J C Soler Bistué; Hongphuc Ha; Renee Sarno; Michelle Don; Angeles Zorreguieta; Marcelo E Tolmasky
Journal:  Antimicrob Agents Chemother       Date:  2007-03-26       Impact factor: 5.191

6.  The aminoglycoside 6'-N-acetyltransferase type Ib encoded by Tn1331 is evenly distributed within the cell's cytoplasm.

Authors:  Ken J Dery; Britta Søballe; Mavee S L Witherspoon; Duyen Bui; Robert Koch; David J Sherratt; Marcelo E Tolmasky
Journal:  Antimicrob Agents Chemother       Date:  2003-09       Impact factor: 5.191

7.  Identification of an Inhibitor of the Aminoglycoside 6'-N-Acetyltransferase type Ib [AAC(6')-Ib] by Glide Molecular Docking.

Authors:  Kevin Chiem; Saumya Jani; Brooke Fuentes; David L Lin; Madeline E Rasche; Marcelo E Tolmasky
Journal:  Medchemcomm       Date:  2015-11-03       Impact factor: 3.597

8.  Inhibition of aminoglycoside 6'-N-acetyltransferase type Ib-mediated amikacin resistance by antisense oligodeoxynucleotides.

Authors:  Renee Sarno; Hongphuc Ha; Natalia Weinsetel; Marcelo E Tolmasky
Journal:  Antimicrob Agents Chemother       Date:  2003-10       Impact factor: 5.191

9.  Temporal appearance of plasmid-mediated quinolone resistance genes.

Authors:  George A Jacoby; Nancy Gacharna; Todd A Black; George H Miller; David C Hooper
Journal:  Antimicrob Agents Chemother       Date:  2009-01-21       Impact factor: 5.191

10.  Complete nucleotide sequence of Klebsiella pneumoniae multiresistance plasmid pJHCMW1.

Authors:  Renee Sarno; Glen McGillivary; David J Sherratt; Luis A Actis; Marcelo E Tolmasky
Journal:  Antimicrob Agents Chemother       Date:  2002-11       Impact factor: 5.191
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