| Literature DB >> 28482212 |
Isabelle Bos1, Stephanie J Vos2, Lutz Frölich3, Johannes Kornhuber4, Jens Wiltfang5, Wolfgang Maier6, Oliver Peters7, Eckhart Rüther8, Sebastiaan Engelborghs9, Ellis Niemantsverdriet10, Ellen Elisa De Roeck11, Magda Tsolaki12, Yvonne Freund-Levi13, Peter Johannsen14, Rik Vandenberghe15, Alberto Lleó16, Daniel Alcolea16, Giovanni B Frisoni17, Samantha Galluzzi18, Flavio Nobili19, Silvia Morbelli20, Alexander Drzezga21, Mira Didic22, Bart N van Berckel23, Eric Salmon24, Christine Bastin25, Solene Dauby26, Isabel Santana26, Inês Baldeiras27, Alexandre de Mendonça28, Dina Silva28, Anders Wallin29, Arto Nordlund29, Preciosa M Coloma30, Angelika Wientzek31, Myriam Alexander32, Gerald P Novak33, Mark Forrest Gordon34, Åsa K Wallin35, Harald Hampel36, Hilkka Soininen37, Sanna-Kaisa Herukka37, Philip Scheltens38, Frans R Verhey2, Pieter Jelle Visser39.
Abstract
We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of 10 risk factors between the subgroups, and used Cox-regression to examine the effect of risk factors on cognitive decline. Depression, obesity, and hypercholesterolemia occurred more often in individuals with low-AD-likelihood, compared with those with a high-AD-likelihood. Only alcohol use increased the risk of cognitive decline, regardless of AD pathology. These results suggest that traditional risk factors for AD are not associated with prodromal AD or with progression to dementia, among subjects with mild cognitive impairment. Future studies should validate these findings and determine whether risk factors might be of influence at an earlier stage (i.e., preclinical) of AD.Entities:
Keywords: Alzheimer's disease; Biomarkers; IWG-2 criteria; NIA-AA criteria; Prognosis; Risk factors
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Year: 2017 PMID： 28482212 DOI： 10.1016/j.neurobiolaging.2017.03.034
Source DB: PubMed Journal: Neurobiol Aging ISSN： 0197-4580 Impact factor: 4.673