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Literature DB >> 28478951

A CRISPR Approach to Neurodegenerative Diseases.

Abstract

A major barrier to developing effective therapies for neurodegenerative diseases is our incomplete understanding of the underlying cellular mechanisms. Genetic screens in human-induced pluripotent stem cell-derived neurons can elucidate such mechanisms. Genome-wide screens using CRISPR interference and CRISPR activation provide complementary biological insights and may reveal potential therapeutic targets.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2017 PMID： 28478951 PMCID： PMC5604856 DOI： 10.1016/j.molmed.2017.04.003

Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951

11 in total

1. LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress.

Authors: Ha Nam Nguyen; Blake Byers; Branden Cord; Aleksandr Shcheglovitov; James Byrne; Prachi Gujar; Kehkooi Kee; Birgitt Schüle; Ricardo E Dolmetsch; William Langston; Theo D Palmer; Renee Reijo Pera
Journal: Cell Stem Cell Date: 2011-03-04 Impact factor: 24.633

2. Next-generation libraries for robust RNA interference-based genome-wide screens.

Authors: Martin Kampmann; Max A Horlbeck; Yuwen Chen; Jordan C Tsai; Michael C Bassik; Luke A Gilbert; Jacqueline E Villalta; S Chul Kwon; Hyeshik Chang; V Narry Kim; Jonathan S Weissman
Journal: Proc Natl Acad Sci U S A Date: 2015-06-15 Impact factor: 11.205

3. CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs.

Authors: Mohammad A Mandegar; Nathaniel Huebsch; Ekaterina B Frolov; Edward Shin; Annie Truong; Michael P Olvera; Amanda H Chan; Yuichiro Miyaoka; Kristin Holmes; C Ian Spencer; Luke M Judge; David E Gordon; Tilde V Eskildsen; Jacqueline E Villalta; Max A Horlbeck; Luke A Gilbert; Nevan J Krogan; Søren P Sheikh; Jonathan S Weissman; Lei S Qi; Po-Lin So; Bruce R Conklin
Journal: Cell Stem Cell Date: 2016-03-10 Impact factor: 24.633

4. Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells.

Authors: Martin Kampmann; Michael C Bassik; Jonathan S Weissman
Journal: Proc Natl Acad Sci U S A Date: 2013-06-05 Impact factor: 11.205

5. Functional genomics of brain aging and Alzheimer's disease: focus on selective neuronal vulnerability.

Authors: Xinkun Wang; Mary L Michaelis; Elias K Michaelis
Journal: Curr Genomics Date: 2010-12 Impact factor: 2.236

6. Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.

Authors: Carmela Sidrauski; Jordan C Tsai; Martin Kampmann; Brian R Hearn; Punitha Vedantham; Priyadarshini Jaishankar; Masaaki Sokabe; Aaron S Mendez; Billy W Newton; Edward L Tang; Erik Verschueren; Jeffrey R Johnson; Nevan J Krogan; Christopher S Fraser; Jonathan S Weissman; Adam R Renslo; Peter Walter
Journal: Elife Date: 2015-04-15 Impact factor: 8.140

7. Molecular biology. Use and abuse of RNAi to study mammalian gene function.

Authors: William G Kaelin
Journal: Science Date: 2012-07-27 Impact factor: 47.728

8. Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells.

Authors: Mason A Israel; Shauna H Yuan; Cedric Bardy; Sol M Reyna; Yangling Mu; Cheryl Herrera; Michael P Hefferan; Sebastiaan Van Gorp; Kristopher L Nazor; Francesca S Boscolo; Christian T Carson; Louise C Laurent; Martin Marsala; Fred H Gage; Anne M Remes; Edward H Koo; Lawrence S B Goldstein
Journal: Nature Date: 2012-01-25 Impact factor: 49.962

9. Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation.

Authors: Max A Horlbeck; Luke A Gilbert; Jacqueline E Villalta; Britt Adamson; Ryan A Pak; Yuwen Chen; Alexander P Fields; Chong Yon Park; Jacob E Corn; Martin Kampmann; Jonathan S Weissman
Journal: Elife Date: 2016-09-23 Impact factor: 8.140

10. Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation.

Authors: Luke A Gilbert; Max A Horlbeck; Britt Adamson; Jacqueline E Villalta; Yuwen Chen; Evan H Whitehead; Carla Guimaraes; Barbara Panning; Hidde L Ploegh; Michael C Bassik; Lei S Qi; Martin Kampmann; Jonathan S Weissman
Journal: Cell Date: 2014-10-09 Impact factor: 41.582

15 in total

1. CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons.

Authors: Ruilin Tian; Mariam A Gachechiladze; Connor H Ludwig; Matthew T Laurie; Jason Y Hong; Diane Nathaniel; Anika V Prabhu; Michael S Fernandopulle; Rajan Patel; Mehrnoosh Abshari; Michael E Ward; Martin Kampmann
Journal: Neuron Date: 2019-08-15 Impact factor: 17.173

2. Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation.

Authors: John J Chen; Diane L Nathaniel; Preethi Raghavan; Maxine Nelson; Ruilin Tian; Eric Tse; Jason Y Hong; Stephanie K See; Sue-Ann Mok; Marco Y Hein; Daniel R Southworth; Lea T Grinberg; Jason E Gestwicki; Manuel D Leonetti; Martin Kampmann
Journal: J Biol Chem Date: 2019-10-02 Impact factor: 5.157

Review 3. CRISPRi and CRISPRa Screens in Mammalian Cells for Precision Biology and Medicine.

Authors: Martin Kampmann
Journal: ACS Chem Biol Date: 2017-10-24 Impact factor: 5.100

Review 4. Emerging Therapies and Novel Targets for TDP-43 Proteinopathy in ALS/FTD.

Authors: Lindsey R Hayes; Petr Kalab
Journal: Neurotherapeutics Date: 2022-07-05 Impact factor: 6.088

Review 5. Exploring the Involvement of the Amyloid Precursor Protein A673T Mutation against Amyloid Pathology and Alzheimer's Disease in Relation to Therapeutic Editing Tools.

Authors: Gabriela Dumitrita Stanciu; Daniela Carmen Ababei; Razvan Nicolae Rusu; Veronica Bild; Bogdan-Ionel Tamba
Journal: Pharmaceutics Date: 2022-06-15 Impact factor: 6.525