PURPOSE: It is widely known that there is low striatal 123I-FP-CIT dopamine transporter single photon emission computed tomography (DAT-SPECT) uptake in patients with dementia with Lewy bodies (DLB). However, a consistent quantitative evaluation method for DAT-SPECT has not yet been established. There are two semi-quantitative software packages for DAT-SPECT available in Japan, namely, DaTView and DaTQUANT. The aim of this study was to identify which of these is superior for distinguishing DLB from AD. Moreover, we aimed to identify which region of the striatum is more suitable for distinguishing DLB from AD. METHODS: Patients with Alzheimer's disease (AD) (n=95) and patients with DLB (n=133) who underwent DAT-SPECT were enrolled. DaTView and DaTQUANT were used as semi-quantitative analysis tools for DAT-SPECT. RESULTS: There were significant correlations in DAT uptake between DaTView and entire regions by DaTQUANT. There was no significant difference in diagnostic accuracy between DaTView and DaTQUANT except in the posterior putamen by DaTQUANT. CONCLUSIONS: For distinguishing DLB from AD, both of DaTView and DaTQUANT software are useful. Moreover, assessing the DAT uptake in entire striatum by DaTView might be sufficient for distinguishing DLB from AD.
PURPOSE: It is widely known that there is low striatal 123I-FP-CITdopamine transporter single photon emission computed tomography (DAT-SPECT) uptake in patients with dementia with Lewy bodies (DLB). However, a consistent quantitative evaluation method for DAT-SPECT has not yet been established. There are two semi-quantitative software packages for DAT-SPECT available in Japan, namely, DaTView and DaTQUANT. The aim of this study was to identify which of these is superior for distinguishing DLB from AD. Moreover, we aimed to identify which region of the striatum is more suitable for distinguishing DLB from AD. METHODS:Patients with Alzheimer's disease (AD) (n=95) and patients with DLB (n=133) who underwent DAT-SPECT were enrolled. DaTView and DaTQUANT were used as semi-quantitative analysis tools for DAT-SPECT. RESULTS: There were significant correlations in DAT uptake between DaTView and entire regions by DaTQUANT. There was no significant difference in diagnostic accuracy between DaTView and DaTQUANT except in the posterior putamen by DaTQUANT. CONCLUSIONS: For distinguishing DLB from AD, both of DaTView and DaTQUANT software are useful. Moreover, assessing the DAT uptake in entire striatum by DaTView might be sufficient for distinguishing DLB from AD.
Authors: Seok Jong Chung; Yang Hyun Lee; Han Soo Yoo; Young H Sohn; Byoung Seok Ye; Jungho Cha; Phil Hyu Lee Journal: Eur J Nucl Med Mol Imaging Date: 2019-04-12 Impact factor: 9.236
Authors: Sule Tinaz; Christopher Chow; Phillip H Kuo; Elizabeth A Krupinski; Hal Blumenfeld; Elan D Louis; George Zubal Journal: Clin Nucl Med Date: 2018-01 Impact factor: 7.794
Authors: Toji Miyagawa; Scott A Przybelski; Daniela Maltais; Hoon-Ki Min; Lennon Jordan; Timothy G Lesnick; Qin Chen; Jonathan Graff-Radford; David Jones; Rodolfo Savica; David Knopman; Ronald Petersen; Walter K Kremers; Leah K Forsberg; Julie A Fields; Tanis J Ferman; Laura Allen; Joseph Parisi; R Ross Reichard; Melissa Murray; Dennis Dickson; Bradley F Boeve; Kejal Kantarci; Val J Lowe Journal: Neurobiol Aging Date: 2020-12-15 Impact factor: 4.673
Authors: Daniela D Maltais; Lennon G Jordan; Hoon-Ki Min; Toji Miyagawa; Scott A Przybelski; Timothy G Lesnick; Robert R Reichard; Dennis W Dickson; Melissa E Murray; Kejal Kantarci; Bradley F Boeve; Val J Lowe Journal: J Nucl Med Date: 2020-03-20 Impact factor: 11.082