Literature DB >> 28475243

The Potential Value of the PI3K/Akt/mTOR Signaling Pathway for Assessing Prognosis in Cervical Cancer and as a Target for Therapy.

Afsane Bahrami1,2, Malihe Hasanzadeh3, Seyed Mahdi Hassanian4,5, Soodabeh ShahidSales6, Majid Ghayour-Mobarhan4, Gordon A Ferns7, Amir Avan4,6.   

Abstract

Cervical cancer is a common gynecological cancer and a leading cause of cancer-related death in women globally. There is a need for the identification of prognostic and predictive biomarker for risk stratification. The phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway is often dysregulated in cervical cancer, indicating that it may be a potential therapeutic target in the treatment of this malignancy, and could perhaps be used as a novel biomarker in the assessment of risk of developing cervical cancer. We aimed to provide an overview of the potential applications of the PI3K/Akt/mTOR pathway as biomarker for risk stratification, in predicting the prognosis of cervical cancer, and for developing new therapeutic approaches in patients with cervical cancer. J. Cell. Biochem. 118: 4163-4169, 2017.
© 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

Entities:  

Keywords:  CERVICAL CANCER; HUMAN PAPILLOMAVIRUSE; PI3K/Akt/mTOR SIGNALING PATHWAY

Mesh：

Substances：

Year:  2017        PMID： 28475243     DOI： 10.1002/jcb.26118

Source DB:  PubMed          Journal:  J Cell Biochem        ISSN： 0730-2312            Impact factor:   4.429


  40 in total

1.  ECT2 promotes malignant phenotypes through the activation of the AKT/mTOR pathway and cisplatin resistance in cervical cancer.

Authors:  Xiaoli Liu; Junhua Zhang; Shuang Ju; Lu Liu; Yu Sun; Lingyu Guo; Qianwei Zhen; Sai Han; Wei Lu; Youzhong Zhang
Journal:  Cancer Gene Ther       Date:  2022-09-02       Impact factor: 5.854

2.  The intelligent knife (iKnife) and its intraoperative diagnostic advantage for the treatment of cervical disease.

Authors:  Menelaos Tzafetas; Anita Mitra; Maria Paraskevaidi; Zsolt Bodai; Ilkka Kalliala; Sarah Bowden; Konstantinos Lathouras; Francesca Rosini; Marcell Szasz; Adele Savage; Julia Balog; James McKenzie; Deirdre Lyons; Phillip Bennett; David MacIntyre; Sadaf Ghaem-Maghami; Zoltan Takats; Maria Kyrgiou
Journal:  Proc Natl Acad Sci U S A       Date:  2020-03-16       Impact factor: 11.205

Review 3.  Cervical Cancer Immunotherapy: Facts and Hopes.

Authors:  Louise Ferrall; Ken Y Lin; Richard B S Roden; Chien-Fu Hung; T-C Wu
Journal:  Clin Cancer Res       Date:  2021-04-22       Impact factor: 12.531

4.  E6-mediated activation of JNK drives EGFR signalling to promote proliferation and viral oncoprotein expression in cervical cancer.

Authors:  Ethan L Morgan; James A Scarth; Molly R Patterson; Christopher W Wasson; Georgia C Hemingway; Diego Barba-Moreno; Andrew Macdonald
Journal:  Cell Death Differ       Date:  2020-12-10       Impact factor: 15.828

5.  Impact of PI3K-AKT-mTOR Signaling Pathway Up-regulation on Prognosis of Penile Squamous-Cell Carcinoma: Results From a Tissue Microarray Study and Review of the Literature.

Authors:  Mounsif Azizi; Dominic H Tang; Daniel Verduzco; Charles C Peyton; Juan Chipollini; Zhigang Yuan; Braydon J Schaible; Jun-Min Zhou; Peter A Johnstone; Anna Giuliano; Jasreman Dhillon; Philippe E Spiess
Journal:  Clin Genitourin Cancer       Date:  2018-09-22       Impact factor: 3.121

6.  Everolimus (RAD001) combined with programmed death-1 (PD-1) blockade enhances radiosensitivity of cervical cancer and programmed death-ligand 1 (PD-L1) expression by blocking the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR)/S6 kinase 1 (S6K1) pathway.

Authors:  Lili Song; Shikai Liu; Sufen Zhao
Journal:  Bioengineered       Date:  2022-04       Impact factor: 6.832

7.  PBX3 is associated with proliferation and poor prognosis in patients with cervical cancer.

Authors:  Hongfang Li; Gaogao Sun; Chang Liu; Jing Wang; Rong Jing; Jie Wang; Xiaohuan Zhao; Xiaoyan Xu; Yongxiu Yang
Journal:  Onco Targets Ther       Date:  2017-11-27       Impact factor: 4.147

8.  Emodin, Physcion, and Crude Extract of Rhamnus sphaerosperma var. pubescens Induce Mixed Cell Death, Increase in Oxidative Stress, DNA Damage, and Inhibition of AKT in Cervical and Oral Squamous Carcinoma Cell Lines.

Authors:  Thais Fernanda Moreira; Juliana Maria Sorbo; Felipe de Oliveira Souza; Barbara Colatto Fernandes; Fernanda Maria Marins Ocampos; Daniella Maria Soares de Oliveira; Carlos Alberto Arcaro; Renata Pires Assis; Andersson Barison; Obdulio Gomes Miguel; Amanda Martins Baviera; Christiane Pienna Soares; Iguatemy Lourenço Brunetti
Journal:  Oxid Med Cell Longev       Date:  2018-07-03       Impact factor: 6.543

9.  Oncogenic role of ALX3 in cervical cancer cells through KDM2B-mediated histone demethylation of CDC25A.

Authors:  Jinhong Qi; Li Zhou; Dongqing Li; Jingyuan Yang; He Wang; Huifang Cao; Yunlan Huang; Zhiming Zhang; Linlin Chang; Chenhao Zhu; Juntong Zhan; Yong Yuan
Journal:  BMC Cancer       Date:  2021-07-16       Impact factor: 4.430

10.  Treatment of melanoma with selected inhibitors of signaling kinases effectively reduces proliferation and induces expression of cell cycle inhibitors.

Authors:  Dorota Ciołczyk-Wierzbicka; Dorota Gil; Piotr Laidler
Journal:  Med Oncol       Date:  2017-12-06       Impact factor: 3.064
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