| Literature DB >> 2847415 |
K F Ready1, M I Sabara, L A Babiuk.
Abstract
The nucleocapsid protein (VP6) and outer capsid glycoprotein (VP7) of bovine rotavirus (BRV) assemble in vitro, in 0.01 M Tris-HCl, pH 8.0, 50 mM CaCl2, into smooth particles resembling double-shelled BRV. That the two proteins interact is demonstrated by the immunoprecipitation of both by antibody directed against either VP6 or VP7. The calcium-dependence, particle morphology, and immunoreactivity in ELISA suggest that VP7 is presented authentically on the outer capsid. The implications for rotavirus morphogenesis are discussed.Entities:
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Year: 1988 PMID： 2847415 DOI： 10.1016/0042-6822(88)90077-3
Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616