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Literature DB >> 28473619

NRF2 mediates γ-globin gene regulation and fetal hemoglobin induction in human erythroid progenitors.

Xingguo Zhu¹, Biaoru Li², Betty S Pace^2,3.

Abstract

Entities: Gene Species

Mesh：

Substances：

Year: 2017 PMID： 28473619 PMCID： PMC5541881 DOI： 10.3324/haematol.2016.160788

Source DB: PubMed Journal: Haematologica ISSN： 0390-6078 Impact factor: 9.941

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16 in total

Review 1. Targeted therapeutic strategies for fetal hemoglobin induction.

Authors: Vijay G Sankaran
Journal: Hematology Am Soc Hematol Educ Program Date: 2011

2. Looping and interaction between hypersensitive sites in the active beta-globin locus.

Authors: Bas Tolhuis; Robert Jan Palstra; Erik Splinter; Frank Grosveld; Wouter de Laat
Journal: Mol Cell Date: 2002-12 Impact factor: 17.970

3. Embryonic lethality and fetal liver apoptosis in mice lacking all three small Maf proteins.

Authors: Hiromi Yamazaki; Fumiki Katsuoka; Hozumi Motohashi; James Douglas Engel; Masayuki Yamamoto
Journal: Mol Cell Biol Date: 2011-12-12 Impact factor: 4.272

4. Identification of fetal hemoglobin-inducing agents using the human leukemia KU812 cell line.

Authors: Sima Zein; Wei Li; Valya Ramakrishnan; Tzu-Fang Lou; Sharanya Sivanand; Ashley Mackie; Betty Pace
Journal: Exp Biol Med (Maywood) Date: 2010-11

Review 5. Control of globin gene expression during development and erythroid differentiation.

Authors: George Stamatoyannopoulos
Journal: Exp Hematol Date: 2005-03 Impact factor: 3.084

6. Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.

Authors: Vijay G Sankaran; Tobias F Menne; Jian Xu; Thomas E Akie; Guillaume Lettre; Ben Van Handel; Hanna K A Mikkola; Joel N Hirschhorn; Alan B Cantor; Stuart H Orkin
Journal: Science Date: 2008-12-04 Impact factor: 47.728

7. Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway.

Authors: Elizabeth R Macari; Christopher H Lowrey
Journal: Blood Date: 2011-04-04 Impact factor: 22.113

8. Small maf (MafG and MafK) proteins negatively regulate antioxidant response element-mediated expression and antioxidant induction of the NAD(P)H:Quinone oxidoreductase1 gene.

Authors: S Dhakshinamoorthy; A K Jaiswal
Journal: J Biol Chem Date: 2000-12-22 Impact factor: 5.157

9. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain.

Authors: K Itoh; N Wakabayashi; Y Katoh; T Ishii; K Igarashi; J D Engel; M Yamamoto
Journal: Genes Dev Date: 1999-01-01 Impact factor: 11.361

10. Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A.

Authors: Jian Xu; Daniel E Bauer; Marc A Kerenyi; Thuy D Vo; Serena Hou; Yu-Jung Hsu; Huilan Yao; Jennifer J Trowbridge; Gail Mandel; Stuart H Orkin
Journal: Proc Natl Acad Sci U S A Date: 2013-04-01 Impact factor: 11.205

11 in total

1. NRF2 mediates γ-globin gene regulation through epigenetic modifications in a β-YAC transgenic mouse model.

Authors: Xingguo Zhu; Caixia Xi; Alexander Ward; Mayuko Takezaki; Huidong Shi; Kenneth R Peterson; Betty S Pace
Journal: Exp Biol Med (Maywood) Date: 2020-07-26

Review 2. Mechanisms of NRF2 activation to mediate fetal hemoglobin induction and protection against oxidative stress in sickle cell disease.

Authors: Xingguo Zhu; Aluya R Oseghale; Lopez H Nicole; Biaoru Li; Betty S Pace
Journal: Exp Biol Med (Maywood) Date: 2019-01-23

NRF2 mediates γ-globin gene regulation and fetal hemoglobin induction in human erythroid progenitors.

Review 1. Targeted therapeutic strategies for fetal hemoglobin induction.

2. Looping and interaction between hypersensitive sites in the active beta-globin locus.

3. Embryonic lethality and fetal liver apoptosis in mice lacking all three small Maf proteins.

4. Identification of fetal hemoglobin-inducing agents using the human leukemia KU812 cell line.

Review 5. Control of globin gene expression during development and erythroid differentiation.

6. Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.

7. Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway.

8. Small maf (MafG and MafK) proteins negatively regulate antioxidant response element-mediated expression and antioxidant induction of the NAD(P)H:Quinone oxidoreductase1 gene.

9. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain.

10. Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A.

1. NRF2 mediates γ-globin gene regulation through epigenetic modifications in a β-YAC transgenic mouse model.

Review 2. Mechanisms of NRF2 activation to mediate fetal hemoglobin induction and protection against oxidative stress in sickle cell disease.

3. Fetal hemoglobin induction in sickle erythroid progenitors using a synthetic zinc finger DNA-binding domain.

4. δ-Aminolevulinate induces fetal hemoglobin expression by enhancing cellular heme biosynthesis.

5. Loss of NRF2 function exacerbates the pathophysiology of sickle cell disease in a transgenic mouse model.

Review 6. Exploring epigenetic and microRNA approaches for γ-globin gene regulation.

7. MIR29B mediates epigenetic mechanisms of HBG gene activation.

Review 8. Targeting Genetic Modifiers of HBG Gene Expression in Sickle Cell Disease: The miRNA Option.

Review 9. Sickle cell disease: progress towards combination drug therapy.

10. Significance of heme oxygenase-1(HMOX1) gene on fetal hemoglobin induction in sickle cell anemia patients.