Literature DB >> 30674214

Mechanisms of NRF2 activation to mediate fetal hemoglobin induction and protection against oxidative stress in sickle cell disease.

Xingguo Zhu1, Aluya R Oseghale2, Lopez H Nicole1, Biaoru Li1, Betty S Pace1,2,3.   

Abstract

IMPACT STATEMENT: Sickle cell disease (SCD) is a group of inherited blood disorders caused by mutations in the human β-globin gene, leading to the synthesis of abnormal hemoglobin S, chronic hemolysis, and oxidative stress. Inhibition of hemoglobin S polymerization by fetal hemoglobin holds the greatest promise for treating SCD. The transcription factor NRF2, is the master regulator of the cellular oxidative stress response and activator of fetal hemoglobin expression. In animal models, various small chemical molecules activate NRF2 and ameliorate the pathophysiology of SCD. This review discusses the mechanisms of NRF2 regulation and therapeutic strategies of NRF2 activation to design the treatment options for individuals with SCD.

Entities:  

Keywords:  KEAP1; NRF2; Sickle cell disease; fetal hemoglobin; oxidative stress

Mesh：

Substances：

Year:  2019        PMID： 30674214      PMCID： PMC6405823          DOI： 10.1177/1535370219825859

Source DB:  PubMed          Journal:  Exp Biol Med (Maywood)        ISSN： 1535-3699


  112 in total

1.  Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages.

Authors:  T Ishii; K Itoh; S Takahashi; H Sato; T Yanagawa; Y Katoh; S Bannai; M Yamamoto
Journal:  J Biol Chem       Date:  2000-05-26       Impact factor: 5.157

Review 2.  Sickle-cell disease.

Authors:  Marie J Stuart; Ronald L Nagel
Journal:  Lancet       Date:  2004 Oct 9-15       Impact factor: 79.321

3.  Oxidative stress and induction of heme oxygenase-1 in the kidney in sickle cell disease.

Authors:  K A Nath; J P Grande; J J Haggard; A J Croatt; Z S Katusic; A Solovey; R P Hebbel
Journal:  Am J Pathol       Date:  2001-03       Impact factor: 4.307

4.  Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease.

Authors:  G F Atweh; M Sutton; I Nassif; V Boosalis; G J Dover; S Wallenstein; E Wright; L McMahon; G Stamatoyannopoulos; D V Faller; S P Perrine
Journal:  Blood       Date:  1999-03-15       Impact factor: 22.113

5.  Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals.

Authors:  Ning Li; Jawed Alam; M Indira Venkatesan; Arantza Eiguren-Fernandez; Debra Schmitz; Emma Di Stefano; Ndaisha Slaughter; Erin Killeen; Xiaorong Wang; Aaron Huang; Meiying Wang; Antonio H Miguel; Arthur Cho; Constantinos Sioutas; Andre E Nel
Journal:  J Immunol       Date:  2004-09-01       Impact factor: 5.422

6.  NAD(P)H:quinone oxidoreductase 1: role as a superoxide scavenger.

Authors:  David Siegel; Daniel L Gustafson; Donna L Dehn; Jin Yi Han; Preecha Boonchoong; Lawrence J Berliner; David Ross
Journal:  Mol Pharmacol       Date:  2004-05       Impact factor: 4.436

7.  Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron.

Authors:  Michael McMahon; Nerys Thomas; Ken Itoh; Masayuki Yamamoto; John D Hayes
Journal:  J Biol Chem       Date:  2004-05-13       Impact factor: 5.157

8.  Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network.

Authors:  Jiying Sun; Marjorie Brand; Yukari Zenke; Satoshi Tashiro; Mark Groudine; Kazuhiko Igarashi
Journal:  Proc Natl Acad Sci U S A       Date:  2004-01-27       Impact factor: 11.205

9.  Targeted disruption of Nrf2 causes regenerative immune-mediated hemolytic anemia.

Authors:  Jong-Min Lee; Kaimin Chan; Yuet Wai Kan; Jeffrey A Johnson
Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-21       Impact factor: 11.205

10.  Effects of 5-aza-2'-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease.

Authors:  Yogen Saunthararajah; Cheryl A Hillery; Don Lavelle; Robert Molokie; Louise Dorn; Linda Bressler; Stefana Gavazova; Yi-Hsiang Chen; Ronald Hoffman; Joseph DeSimone
Journal:  Blood       Date:  2003-08-07       Impact factor: 22.113
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  5 in total

1.  Redox Signaling in Sickle Cell Disease.

Authors:  Deirdre Nolfi-Donegan; Tirthadipa Pradhan-Sundd; Kirkwood A Pritchard; Cheryl A Hillery
Journal:  Curr Opin Physiol       Date:  2019-05-02

Review 2.  Relationship between oxidative stress and nuclear factor-erythroid-2-related factor 2 signaling in diabetic cardiomyopathy (Review).

Authors:  Xia Wu; Leitao Huang; Jichun Liu
Journal:  Exp Ther Med       Date:  2021-04-25       Impact factor: 2.447

Review 3.  Streptococcus pneumoniae and Its Virulence Factors H2O2 and Pneumolysin Are Potent Mediators of the Acute Chest Syndrome in Sickle Cell Disease.

Authors:  Joyce Gonzales; Trinad Chakraborty; Maritza Romero; Mobarak Abu Mraheil; Abdullah Kutlar; Betty Pace; Rudolf Lucas
Journal:  Toxins (Basel)       Date:  2021-02-17       Impact factor: 4.546

4.  EPCR-PAR1 biased signaling regulates perfusion recovery and neovascularization in peripheral ischemia.

Authors:  Magdalena L Bochenek; Rajinikanth Gogiraju; Stefanie Großmann; Janina Krug; Jennifer Orth; Sabine Reyda; George S Georgiadis; Henri M Spronk; Stavros Konstantinides; Thomas Münzel; John H Griffin; Philipp Wild; Christine Espinola-Klein; Wolfram Ruf; Katrin Schäfer
Journal:  JCI Insight       Date:  2022-07-22

5.  Selenium Status and Hemolysis in Sickle Cell Disease Patients.

Authors:  Emília Delesderrier; Cláudia S Cople-Rodrigues; Juliana Omena; Marcos Kneip Fleury; Flávia Barbosa Brito; Adriana Costa Bacelo; Josely Correa Koury; Marta Citelli
Journal:  Nutrients       Date:  2019-09-13       Impact factor: 5.717
  5 in total

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