Literature DB >> 2846677

Des-acetyl-alpha-MSH and not alpha-MSH is the major form of alpha-MSH in amniotic fluid.

A Mauri1, A Argiolas, M R Melis, L Lai, W Fratta, A Caruso, A Lanzone, F Serri, F Caminiti, S Mancuso.   

Abstract

Immunoreactive alpha-melanocyte stimulating hormone (IR-alpha-MSH)-like activity was measured by radioimmunoassay (RIA) in at term pregnancy amniotic fluid prior and after adsorption on a Sep-pak C18 cartridge. alpha-MSH activity was 3-4 times lower after Sep-pak purification but, unlike the levels of IR-alpha-MSH in the fluid analyzed in toto, increased linearly with the volume of fluid analyzed. Furthermore, fractionation by high pressure liquid chromatography (HPLC) revealed that IR-alpha-MSH recovered from the Sep-pak was due to several peptides rather than to a single peptide. The most abundant of them (50% of total activity) behaved like authentic des-acetyl-alpha-MSH. Since des-acetyl-alpha-MSH is also the most abundant alpha-MSH-like peptide in the fetal pituitary gland, the present results suggest that the fetal pituitary is a main source of des-acetyl-alpha-MSH in the amniotic fluid.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 2846677     DOI： 10.1007/bf03349052

Source DB:  PubMed          Journal:  J Endocrinol Invest        ISSN： 0391-4097            Impact factor:   4.256


  17 in total

1.  Differential effects of synthetic adrenocorticotropin1-24 and alpha-melanocyte-stimulating hormone on adrenal function in human and sheep fetuses.

Authors:  J A Glickman; G D Carson; J R Challis
Journal:  Endocrinology       Date:  1979-01       Impact factor: 4.736

2.  The development of fetal adrenal function.

Authors:  J R Challis; E L Manchester; B F Mitchell; J E Patrick
Journal:  Ciba Found Symp       Date:  1981

3.  Regulation of the fetal human adrenal cortex: effects of adrenocorticotropin on growth and function of monolayer cultures of fetal and definitive zone cells.

Authors:  M H Simonian; G N Gill
Journal:  Endocrinology       Date:  1981-05       Impact factor: 4.736

4.  Immunoreactive alpha-MSH in human plasma in pregnancy.

Authors:  D Clark; A J Thody; S Shuster; H Bowers
Journal:  Nature       Date:  1978-05-11       Impact factor: 49.962

5.  alpha-Melanocyte-stimulating hormone and adrenocorticotropin in the regulation of glucocorticoid secretion during the perinatal period in sheep.

Authors:  A J Llanos; J Ramachandran; R K Creasy; A M Rudolph; M Serón-Ferré
Journal:  Endocrinology       Date:  1979-09       Impact factor: 4.736

6.  Amniotic fluid beta-endorphin and alpha-melanocyte--stimulating hormone immunoreactivity in normal and complicated pregnancies.

Authors:  W A Divers; R D Stewart; M M Wilkes; S S Yen
Journal:  Am J Obstet Gynecol       Date:  1982-11-01       Impact factor: 8.661

7.  Common precursor to corticotropins and endorphins.

Authors:  R E Mains; B A Eipper; N Ling
Journal:  Proc Natl Acad Sci U S A       Date:  1977-07       Impact factor: 11.205

8.  Influence of alpha-melanocyte-stimulating hormone (alpha-MSH), growth hormone (GH) and fetal brain extracts on intrauterine growth of fetus and placenta in the rat.

Authors:  W J Honnebier; D F Swaab
Journal:  J Obstet Gynaecol Br Commonw       Date:  1974-06

9.  Stimulation of intra-uterine growth in rat by alpha-melanocyte-stimulating hormone.

Authors:  D F Swaab; M Visser; F J Tilders
Journal:  J Endocrinol       Date:  1976-09       Impact factor: 4.286

10.  Adrenocorticotrophic and melanocyte-stimulating peptides in the human pituitary.

Authors:  A P Scott; P J Lowry
Journal:  Biochem J       Date:  1974-06       Impact factor: 3.857
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.