RATIONALE: Considering that the loss of cell cycle and apoptosis control constitutes a central event in human papilloma virus' (HPV)-mediated carcinogenesis, the reason of this study is to insight to the HPV life cycle. OBJECTIVE: The purpose of the study is to analyze the HPV molecular biology and cervical cancer association. METHODS AND RESULTS: Brief review of current literature on the HPV life cycle and cervical carcinogenesis. DISCUSSION: Among the HPV associated cancers, cervical cancer still ranks number two in the global cancer incidence of women. A central component of the association between HPV and cervical carcinogenesis is the ability of HPV to persist in the lower genital tract for long periods of time without being cleared because of its evasion mechanisms.
RATIONALE: Considering that the loss of cell cycle and apoptosis control constitutes a central event in human papilloma virus' (HPV)-mediated carcinogenesis, the reason of this study is to insight to the HPV life cycle. OBJECTIVE: The purpose of the study is to analyze the HPV molecular biology and cervical cancer association. METHODS AND RESULTS: Brief review of current literature on the HPV life cycle and cervical carcinogenesis. DISCUSSION: Among the HPV associated cancers, cervical cancer still ranks number two in the global cancer incidence of women. A central component of the association between HPV and cervical carcinogenesis is the ability of HPV to persist in the lower genital tract for long periods of time without being cleared because of its evasion mechanisms.
Authors: Sreejata Chatterjee; Sa Do Kang; Samina Alam; Anna C Salzberg; Janice Milici; Sjoerd H van der Burg; Willard Freeman; Craig Meyers Journal: J Virol Date: 2019-08-13 Impact factor: 5.103
Authors: Daniel N Santiago; Johannes P W Heidbuechel; Wendy M Kandell; Rachel Walker; Julie Djeu; Christine E Engeland; Daniel Abate-Daga; Heiko Enderling Journal: Viruses Date: 2017-08-23 Impact factor: 5.048
Authors: Simona Roxana Georgescu; Cristina Iulia Mitran; Madalina Irina Mitran; Constantin Caruntu; Maria Isabela Sarbu; Clara Matei; Ilinca Nicolae; Sandra Milena Tocut; Mircea Ioan Popa; Mircea Tampa Journal: J Immunol Res Date: 2018-08-27 Impact factor: 4.818